Study of EEG Neurofeedback Using Prism System to Reduce PTSD Symptoms in Adults Aged 18 to 65

What this Trial Is About

Researchers are evaluating whether Prism training, a type of EEG neurofeedback using machine learning-based amygdala biomarkers, can reduce symptoms of post-traumatic stress disorder PTSD in U.S. military Veterans and civilians. This study compares Prism training to a sham training that mimics the experience but does not provide real brain feedback, aiming to see if adding Prism to usual PTSD treatment helps decrease symptoms. The trial is prospective, randomized, and double-blinded, sponsored by the Foundation for Atlanta Veterans Education and Research, Inc. Participants will undergo 15 in-person training sessions lasting about one hour each, held twice a week over approximately eight weeks. After this main training, two booster sessions occur one month and two months later. One group receives active Prism EEG neurofeedback training, while the other group receives sham training. Both trainings are added to participants usual PTSD care. During the study, participants will complete three detailed interviews before starting training, after nine weeks of training, and one month following the last booster session around 20 weeks from the start. Researchers will measure changes in PTSD symptoms using the CAPS-5-R score from enrollment to week 9 and again at week 20. The study includes monitoring vision and hearing, adherence to the schedule, and stable medication use. Participants are followed for about 20 weeks in total.

A Study of a Novel EEG Neurofeedback System for PTSD Treatment