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A Study of NT 201 in Adults With Moderate to Severe Platysma Prominence in the United States
Led by Merz North America, Inc. · Updated on 2026-04-08
300
Participants Needed
28
Research Sites
122 weeks
Total Duration
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AI-Summary
What this Trial Is About
The purpose of this study is to assess the safety and efficacy of NT 201 compared with placebo in participants with moderate to severe platysma prominence. The study will be conducted in two periods: Main Period (MP) and Open label Extension Period (OLEX).
CONDITIONS
Official Title
A Study of NT 201 in Adults With Moderate to Severe Platysma Prominence in the United States
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Presence of four platysmal bands (medial and lateral, left and right) assessed at screening and baseline
- Score of Grade 3 (moderate) or Grade 4 (severe) on the MAPS-D at maximum contraction by investigator and participant
You will not qualify if you...
- Allergy or hypersensitivity to botulinum toxin of any type or its ingredients
- Medical conditions that increase risk with botulinum toxin exposure or interfere with neuromuscular function
- Serious diseases or disorders that compromise safety or study assessments
- Botulinum toxin treatment to face (below lower orbital rim), jawline, or neck within last 7 months
- History of lower face, neck, or chest surgery or aesthetic procedures in past 12 months; orthodontic procedures in past 6 months
- Planned surgery or aesthetic procedures to lower face, neck, or chest during study
- Anticipated need for botulinum toxin treatment for other indications during study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 28 locations
1
Merz Investigative Site
Scottsdale, Arizona, United States, 85260
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2
Merz Investigative Site
Encino, California, United States, 91436
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3
Merz Investigative Site
Los Angeles, California, United States, 90069
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4
Merz Investigative Site
Redondo Beach, California, United States, 90277
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5
Merz Investigative Site
Santa Monica, California, United States, 90404
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6
Merz Investigative Site
Vista, California, United States, 92803
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7
Merz Investigative Site
Greenwood Village, Colorado, United States, 80111
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8
Merz Investigative Site
Westport, Connecticut, United States, 06880
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9
Merz Investigative Site
Washington D.C., District of Columbia, United States, 20037
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10
Merz Investigative Site
Aventura, Florida, United States, 33180
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11
Merz Investigative Site
Boca Raton, Florida, United States, 33431
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12
Merz Investigative Site
Bradenton, Florida, United States, 34209
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13
Merz Investigative Site
Coral Gables, Florida, United States, 33143
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14
Merz Investigative Site
Coral Gables, Florida, United States, 33146
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15
Merz Investigative Site
West Palm Beach, Florida, United States, 33404
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16
Merz Investigative Site
Alpharetta, Georgia, United States, 30005
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17
Merz Investigative Site
Naperville, Illinois, United States, 60563
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18
Merz Investigative Site
Hunt Valley, Maryland, United States, 21030
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19
Merz Investigative Site
Mount Kisco, New York, United States, 10549
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20
Merz Investigative Site
New York, New York, United States, 10021
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21
Merz Investigative Site
New York, New York, United States, 10028
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22
Merz Investigative Site
Chapel Hill, North Carolina, United States, 27517
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23
Merz Investigative Site
Wilmington, North Carolina, United States, 28405
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24
Merz Investigative Site
Ardmore, Pennsylvania, United States, 19003
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25
Merz Investigative Site
Nashville, Tennessee, United States, 37215
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26
Merz Investigative Site
Dallas, Texas, United States, 75225
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27
Merz Investigative Site
Arlington, Virginia, United States, 22209
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28
Merz Investigative Site
San Juan, Puerto Rico, 00917
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Research Team
P
Public Disclosure Manager Merz Aesthetics
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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