A Phase 3, Randomized, Parallel-group, Double-blind, Multicenter Study Investigating the Safety and Efficacy of NT 201 Compared With Placebo in Adult Participants With Moderate to Severe Platysma Prominence in Europe

Led by Merz Aesthetics GmbH · Updated on 2026-07-23

300

Participants Needed

Research Sites

43 weeks

Total Duration

AI-Summary

What this Trial Is About

The purpose of this study is to assess the safety and efficacy of NT 201 compared with placebo in participants with moderate to severe platysma prominence. The study will be conducted in two periods: Main Period (MP) and Open label Extension Period (OLEX).

CONDITIONS

Brief Title

A Study of NT 201 in Adults With Moderate to Severe Platysma Prominence in Europe (PLATINUM EU)

Who Can Participate

Age: 18Years - 65Years

All Genders

Eligibility Criteria

Inclusion Criteria:

Presence of four (medial and lateral, left and right) platysmal bands assessed at screening and baseline.
A score of Grade 3 ('moderate') or Grade 4 ('severe') on the MAPSD at maximum contraction by the investigator AND participant.

Exclusion Criteria:

Hypersensitivity or a history of allergic reaction to botulinum toxin of any serotype or any of their formulation ingredients.
Any medical condition that may put the participant at increased risk with exposure to botulinum toxin of any serotype, or any disorders that might interfere with neuromuscular function.
Any serious disease or disorder that could interfere with the safe completion of treatment or with study outcome assessments, or compromise participant safety.
Botulinum toxin treatment in the face (below the lower orbital rim), jawline, or neck within the last seven months.
History of lower face surgery, neck or chest surgery, and aesthetic procedures in the past 12 months and/or orthodontic procedures in the past 6 months.
Planned surgery or aesthetic procedures to the lower face, neck, or chest during the study period.
Anticipated need for treatment with botulinum toxin of any serotype for any indication during the study (other than study products).

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A Phase 3, Randomized, Parallel-group, Double-blind, Multicenter Study Investigating the Safety and Efficacy of NT 201 Compared With Placebo in Adult Participants With Moderate to Severe Platysma Prominence in Europe

On this page

AI-Summary

What this Trial Is About

Brief Title

Who Can Participate

Eligibility Criteria

Not the Right Trial for You?

On this page

Who Can Participate

Eligibility Criteria