Actively Recruiting
A Study of NT 201 in Adults With Moderate to Severe Platysma Prominence in Europe (PLATINUM EU)
Led by Merz Aesthetics GmbH · Updated on 2026-04-01
300
Participants Needed
26
Research Sites
108 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to assess the safety and efficacy of NT 201 compared with placebo in participants with moderate to severe platysma prominence. The study will be conducted in two periods: Main Period (MP) and Open label Extension Period (OLEX).
CONDITIONS
Official Title
A Study of NT 201 in Adults With Moderate to Severe Platysma Prominence in Europe (PLATINUM EU)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Presence of four platysmal bands (medial and lateral, left and right) at screening and baseline
- Moderate (Grade 3) or severe (Grade 4) platysma prominence on the MAPS-D scale at maximum contraction by both investigator and participant
You will not qualify if you...
- Allergy or hypersensitivity to botulinum toxin or its ingredients
- Medical conditions increasing risk with botulinum toxin or interfering with neuromuscular function
- Serious diseases that could affect treatment safety or study assessments
- Botulinum toxin treatment in face, jawline, or neck within past 7 months
- History of lower face, neck, or chest surgery, aesthetic or orthodontic procedures in past 12 months
- Planned surgery or aesthetic procedures to lower face, neck, or chest during study
- Expected need for botulinum toxin treatment for any reason other than study products during the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 26 locations
1
Merz Investigative Site
Munich, Bavaria, Germany, 80539
Actively Recruiting
2
Merz Investigative Site
Blankenfelde-Mahlow, Brandenburg, Germany, 15831
Actively Recruiting
3
Merz Investigative Site
Potsdam, Brandenburg, Germany, 14467
Actively Recruiting
4
Merz Investigative Site
Friedrichsdorf, Hesse, Germany, 61381
Actively Recruiting
5
Merz Investigative Site
Kassel, Hesse, Germany, 34117
Actively Recruiting
6
Merz Investigative Site
Bochum, North Rhine-Westphalia, Germany, 44793
Actively Recruiting
7
Merz Investigative Site
Düsseldorf, North Rhine-Westphalia, Germany, 40212
Actively Recruiting
8
Merz Investigative Site
Drensteinfurt, Germany, 48317
Actively Recruiting
9
Merz Investigative Site
Hamburg, Germany, 20146
Actively Recruiting
10
Merz Investigative Site
Hamburg, Germany, 29354
Actively Recruiting
11
Merz Investigative Site
Wuppertal, Germany, 42287
Actively Recruiting
12
Merz Investigative Site
Krakow, Lesser Poland Voivodeship, Poland, 30-002
Actively Recruiting
13
Merz Investigative Site
Oświęcim, Lesser Poland Voivodeship, Poland, 32-600
Actively Recruiting
14
Merz Investigative Site
Lublin, Lublin Voivodeship, Poland, 20-607
Actively Recruiting
15
Merz Investigative Site
Warsaw, Masovian Voivodeship, Poland, 00-716
Actively Recruiting
16
Merz Investigative Site
Warsaw, Masovian Voivodeship, Poland, 01-142
Actively Recruiting
17
Merz Investigative Site
Warsaw, Masovian Voivodeship, Poland, 02-482
Actively Recruiting
18
Merz Investigative Site
Warsaw, Masovian Voivodeship, Poland, 02-953
Actively Recruiting
19
Merz Investigative Site
Bialystok, Podlaskie Voivodeship, Poland, 15-453
Actively Recruiting
20
Merz Investigative Site
Gdynia, Pomeranian Voivodeship, Poland, 81-537
Actively Recruiting
21
Merz Investigative Site
Warsaw, Poland, 02-962
Actively Recruiting
22
Merz Investigative Site
Lodz, Łódź Voivodeship, Poland, 90-436
Actively Recruiting
23
Merz Investigative Site
Ostrowiec Świętokrzyski, Świętokrzyskie Voivodeship, Poland, 27-400
Actively Recruiting
24
Merz Investigative Site
Pamplona, Navarre, Spain, 31008
Actively Recruiting
25
Merz Investigative Site
Madrid, Spain, 28001
Not Yet Recruiting
26
Merz Investigative Site
Valencia, Spain, 46010
Actively Recruiting
Research Team
P
Public Disclosure Manager Merz Aesthetics
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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