Actively Recruiting
A Study of Obexelimab in Patients With Systemic Lupus Erythematosus
Led by Zenas BioPharma (USA), LLC · Updated on 2025-07-30
190
Participants Needed
82
Research Sites
102 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to examine the efficacy and safety of obexelimab in participants with systemic lupus erythematosus (SLE).
CONDITIONS
Official Title
A Study of Obexelimab in Patients With Systemic Lupus Erythematosus
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Males and females aged 18 to 70 years
- Diagnosed with systemic lupus erythematosus (SLE) at least 24 weeks prior to screening and meeting 2019 EULAR/ACR classification criteria
- Active SLE with hSLEDAI score ≥ 6 and clinical hSLEDAI ≥ 4 at screening and Day 1
- BILAG-2004 Grade A or B in one or more organ systems at screening and Day 1
- Treated with one or more background nonbiologic lupus standard of care therapies: oral corticosteroid, antimalarial, and/or immunosuppressant
You will not qualify if you...
- Active lupus nephritis requiring additional or non-permitted therapy
- History of thrombosis or embolism in the past 6 months, or in past 12 months associated with antiphospholipid syndrome or similar conditions
- Active skin conditions other than cutaneous lupus erythematosus that could interfere with study assessments
- Active severe neuropsychiatric or central nervous system lupus
- Current inflammatory diseases other than SLE that might affect lupus symptom assessment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 82 locations
1
Sierra Pacific Arthritis and Rheumatology Centers
Fresno, California, United States, 93710
Actively Recruiting
2
California Research Institute
Huntington Park, California, United States, 90255
Actively Recruiting
3
University of California, San Diego
La Jolla, California, United States, 92037
Actively Recruiting
4
Clinical Research of West Florida, Inc
Clearwater, Florida, United States, 33765
Actively Recruiting
5
Clinical Research of West Florida, Inc.
Tampa, Florida, United States, 33606
Actively Recruiting
6
Emory University
Atlanta, Georgia, United States, 30322
Actively Recruiting
7
Accurate Clinical Research
Lake Charles, Louisiana, United States, 70605
Actively Recruiting
8
Henry Ford Hospital
Detroit, Michigan, United States, 48202
Actively Recruiting
9
June DO, PC
Lansing, Michigan, United States, 48911
Actively Recruiting
10
Juno DO, PC
Lansing, Michigan, United States, 48911
Actively Recruiting
11
DJL Clinical Research PLLC
Charlotte, North Carolina, United States, 28211
Actively Recruiting
12
Oklahoma Medical Research Foundation
Oklahoma City, Oklahoma, United States, 73104-5005
Actively Recruiting
13
Penn State - Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
14
Prolato Clinical Research Center (PCRC)
Houston, Texas, United States, 77054
Actively Recruiting
15
Accurate Clinical Research
Houston, Texas, United States, 77089
Actively Recruiting
16
Prime Clinical Research - Mansfield
Mansfield, Texas, United States, 76063
Actively Recruiting
17
CHU de Liege
Liège, Belgium
Actively Recruiting
18
Medical Center Medtech Services EOOD
Haskovo, Bulgaria, 6304
Actively Recruiting
19
University Multiprofile Hospital for Active Treatment "Eurohospital Plovdiv"
Plovdiv, Bulgaria, 4004
Actively Recruiting
20
Richmond Clinical Trials
Richmond, British Columbia, Canada, V6V 2L1
Actively Recruiting
21
Riverside Professional Centre
Sydney, Nova Scotia, Canada, B1S 3N1
Actively Recruiting
22
Anhui Provincial Hospital (The First Affiliated Hospital of USTC)
Hefei, Anhui, China, 230001
Actively Recruiting
23
Beijing Friendship Hospital, Capital Medical University
Beijing, Beijing Municipality, China, 100044
Actively Recruiting
24
Peking University People's Hospital
Beijing, Beijing Municipality, China, 100044
Actively Recruiting
25
The First Affiliated Hospital, Sun Yat-sen University
Guangzhou, Guangdong, China
Actively Recruiting
26
Shenzhen People's Hospital
Shenzhen, Guangdong, China, 518020
Actively Recruiting
27
The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China, 050005
Actively Recruiting
28
The Second Affiliated Hospital of Nanchang University
Nanchang, Jiangx, China, 330008
Actively Recruiting
29
The Second Affiliated Hospital of Nanchang University
Nanchang, Jiangx, China, 330008
Actively Recruiting
30
Lanzhou University Second Hospital
Pudong, Shanghai Municipality, China, 200127
Actively Recruiting
31
Renji Hospital, Shanghai Jiaotong University School of Medicine
Shanghai, Shanghai Municipality, China, 200001
Actively Recruiting
32
The Second Affiliated Hospital of Soochow University
Suzhou, China, 215025
Actively Recruiting
33
Shanxi Bethune Hospital
Taiyuan, China, 030032
Actively Recruiting
34
The First Affiliated Hospital of Ziamen University
Xiamen, China, 361003
Actively Recruiting
35
Sjaellands Universitetshospital, Koge
Køge, Denmark, 4600
Actively Recruiting
36
Medicover Munchen Ost MVZ
München, Bavaria, Germany, 81667
Actively Recruiting
37
Uniklinik Koln
Cologne, Germany
Actively Recruiting
38
Attikon University General Hospital
Chaïdári, Athens, Greece, 12462
Actively Recruiting
39
General Hospital Asklepieio Voulas
Voula, Athens, Greece, 16673
Actively Recruiting
40
University General Hospital of Heraklion
Heraklion, Greece, 71500
Actively Recruiting
41
Olympion General Clinic
Pátrai, Greece, 26443
Actively Recruiting
42
Kianous Stavros
Thessaloniki, Greece, 54636
Actively Recruiting
43
General Hospital of Thessaloniki ''Hippokration''
Thessaloniki, Greece, 54642
Actively Recruiting
44
Policlinico Universitario Campus Biomedico Di Roma
Roma, Italy, 00128
Actively Recruiting
45
Centro Ricerche Cliniche Di Verona S.r.l.
Verona, Italy, 37134
Actively Recruiting
46
Hospital of Japan Community Health Care Organization Chukyo Hospital
Nagoya, Aichi-ken, Japan, 457-8510
Actively Recruiting
47
Hospital of the University of Occupational and Environmental Health
Kitakyushu-shi, Fukuoka, Japan, 807-8556
Actively Recruiting
48
Hospital of Shinkenko Clinic
Naha, Okinawa, Japan, 900-001
Actively Recruiting
49
Hokkaido University Hospital
Kita-ku, Sapporo Hokkaido, Japan, 060-8648
Actively Recruiting
50
Juntendo University Hospital
Bunkyō City, Japan, 113843
Actively Recruiting
51
Clinstile, S.A. de C.V.
Mexico City, Cuidad de Mexico, Mexico
Actively Recruiting
52
PanAmerican Clinical Research
Guadalajara, Jalisco, Mexico
Actively Recruiting
53
Eme Red Hospitalaria
Mérida, Yucatán, Mexico
Actively Recruiting
54
Kohler and Milsten Research
Mérida, Yucatán, Mexico
Actively Recruiting
55
Oaxaca Site Management Organization
Oaxaca City, Mexico, 68000
Actively Recruiting
56
Prywatna Praktyka Lekarska Prof Hab Med Pawel Hrycaj
Poznan, Greater Poland Voivodeship, Poland, 61-397
Actively Recruiting
57
Centrum Medyczne Plejady
Krakow, Lesser Poland Voivodeship, Poland, 30-363
Actively Recruiting
58
MICS Centrum Medyczne Warszawa
Warsaw, Masovian Voivodeship, Poland, 00-874
Actively Recruiting
59
MICS Centrum Medyczne Bydgoszcz
Bydgoszcz, Poland, 85090
Actively Recruiting
60
Krakowskie Centrum Medyczne
Krakow, Poland, 31501
Actively Recruiting
61
SOMED CR
Lodz, Poland, 05260
Actively Recruiting
62
SPZOZ Uniwersytecki Szpital Kliniczny nr 1 im Norberta Barlickiego Uniwersytetu Medycznego w Lodzi
Lodz, Poland, 90153
Actively Recruiting
63
Pracownia Badan Klinicznych Salus
Wroclaw, Poland, 50570
Actively Recruiting
64
Hospital Egas Moniz
Lisbon, Portugal, 1349019
Actively Recruiting
65
ULS de Santa Maria, EPE - Hospital de Santa Maria
Lisbon, Portugal, 1649-035
Actively Recruiting
66
ULS da Arrábida, E.P.E. - Hospital de São Bernardo
Setúbal, Portugal, 2910-446
Actively Recruiting
67
Centro Reumatologico de Caguas
Caguas, Puerto Rico, Puerto Rico, 00725
Actively Recruiting
68
Latin Clinical Trial Center
San Juan, Puerto Rico, Puerto Rico, 00909
Actively Recruiting
69
Centrul Medical de Diagnostic si Tratament Ambulator NEOMED SRL
Brasov, Romania, 500283
Actively Recruiting
70
Dr I Cantacuzino Clinical Hospital
Bucharest, Romania, 030167
Actively Recruiting
71
FARMOVS
Bloemfontein, South Africa, 9301
Actively Recruiting
72
Panorama Medical Centre
Cape Town, South Africa, 7500
Actively Recruiting
73
FutureMeds DKF
Madrid, Spain, 28002
Actively Recruiting
74
Hospital Universitario Ramón y Cajal
Madrid, Spain, 28034
Actively Recruiting
75
Hospital Universitario La Paz
Madrid, Spain, 28046
Actively Recruiting
76
Hospital Universitario Virgen del Rocío
Seville, Spain, 41013
Actively Recruiting
77
Buddhist Tzu Chi General Hospital
Chiayi City, Taiwan, 622
Actively Recruiting
78
Kaohsiung Veterans General Hospital
Kaohsiung City, Taiwan, 81362
Actively Recruiting
79
Chung Shan Medical University Hospital
Taichung, Taiwan, 402
Actively Recruiting
80
Taipei Medical University Hospital
Taipei, Taiwan, 110
Actively Recruiting
81
Taipei Veterans General Hospital
Taipei, Taiwan, 1121
Actively Recruiting
82
Chang Gung Memorial Hospital
Taoyuan, Taiwan, 333
Actively Recruiting
Research Team
P
Patient and Medical Information
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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