What this Trial Is About

Glaucoma is a chronic eye disease that causes progressive damage to the optic nerve and loss of vision, making it the second leading cause of blindness worldwide and the leading cause of irreversible blindness. This research investigates how advanced glaucoma progresses over three years by comparing three different tests: a functional test called the visual field exam and two anatomical imaging methods called OCT angiography (OCTa) and OCT retinal nerve fiber layer thickness (OCTrnfl). These tests help to understand changes in nerve and blood vessel health in the eye. Participants will undergo peripapillary angiography using OCT at the start of the study and then annually for three years. This non-invasive imaging technique measures the density of blood vessels around the optic nerve head. Alongside this, the visual field test and OCTrnfl measurements will be used to monitor changes in vision and nerve fiber thickness. The study aims to assess how these measurements change over time in patients with advanced glaucoma. During the study, participants will be regularly evaluated using these imaging and functional tests to track disease progression. Researchers will measure changes in vascular density, optic nerve fiber thickness, and visual field loss over three years. The findings will help determine which tests best detect progression in advanced glaucoma. Safety and quality of imaging will also be monitored, with total participation lasting three years.

Study of OCT Peripapillary Angiography in Patients With Advanced Glaucoma