Actively Recruiting
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
Led by Cytokinetics · Updated on 2026-05-05
1800
Participants Needed
185
Research Sites
153 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to find out if the investigational drug called omecamtiv mecarbil can reduce the risk of the effects of heart failure, like hospitalization, transplantation, or death in patients with heart failure and severely reduced ejection fraction.
CONDITIONS
Official Title
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 85 years at informed consent
- History of chronic heart failure with reduced ejection fraction for at least 3 months
- Regular use of oral loop diuretics
- For patients without atrial fibrillation/flutter (AFF) on screening ECG: left ventricular ejection fraction (LVEF) less than 30% within 6 months and NT-proBNP ≥ 1000 pg/mL (BNP ≥ 300 pg/mL)
- For patients with AFF on screening ECG: LVEF less than 25% within 6 months, NT-proBNP ≥ 3000 pg/mL (BNP ≥ 900 pg/mL), and not currently taking digoxin
- Recent heart failure event defined as current hospitalization for heart failure, or heart failure event within 12 months prior to screening, or outpatient increase in oral diuretics due to worsening symptoms with additional dosing criteria
- Established on regional standard-of-care heart failure therapies for at least 30 days prior to screening
- Systolic blood pressure 140 mmHg or less
You will not qualify if you...
- Taking digoxin if atrial fibrillation/flutter (AFF) is present on screening ECG
- Recent event or procedure affecting ejection fraction within 3 months (e.g., acute coronary syndrome, cardiac surgery, valve surgery, cardiac resynchronization, or contractility modulation therapy)
- Admission to long-term care or hospice
- Life expectancy less than 12 months due to non-cardiovascular causes
- Intravenous inotropes or vasopressors within 3 days prior to screening
- Mechanical hemodynamic support or mechanical ventilation within 7 days prior to screening
- Intravenous diuretics, vasodilators, or supplemental oxygen therapy within 12 hours prior to screening (except for nocturnal oxygen for sleep apnea or heart failure)
- Estimated glomerular filtration rate (eGFR) less than 20 mL/min/1.73m2 or on dialysis
- Previous solid organ transplant
- Participation in another investigational drug or device study within 30 days prior to screening
- Previous treatment with omecamtiv mecarbil in a clinical trial
- Pregnancy, planning pregnancy, or breastfeeding during or shortly after treatment
- Presence of primary infiltrative cardiomyopathy or severe stenotic valvular disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 185 locations
1
Advanced Cardiovascular, LLC
Alexander City, Alabama, United States, 35010
Actively Recruiting
2
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35233
Actively Recruiting
3
Pima Heart and Vascular Clinical Research
Tucson, Arizona, United States, 85741
Withdrawn
4
National Heart Institute
Beverly Hills, California, United States, 90211
Actively Recruiting
5
UC San Diego Health - Sulpizio Cardiovascular Center
La Jolla, California, United States, 92037
Actively Recruiting
6
Nutrition Research Center (SPH)
Loma Linda, California, United States, 92350
Actively Recruiting
7
Keck Medical Center of USC (outpatient clinic)
Los Angeles, California, United States, 90033
Actively Recruiting
8
UCLA Medical Center Cardiovascular Clinic
Los Angeles, California, United States, 90095
Actively Recruiting
9
University of California, Irvine Medical Center
Orange, California, United States, 92868
Actively Recruiting
10
Sutter Institute for Medical Research (SIMR)
Sacramento, California, United States, 95816
Actively Recruiting
11
UC Davis Health
Sacramento, California, United States, 95817
Actively Recruiting
12
San Diego Cardiac Center
San Diego, California, United States, 92123
Actively Recruiting
13
California Pacific Medical Center Van Ness Campus
San Francisco, California, United States, 94109
Actively Recruiting
14
Kaiser Permanente Santa Clara
Santa Clara, California, United States, 95051
Actively Recruiting
15
Stanford University Hospital / Stanford Health Care
Stanford, California, United States, 94303
Actively Recruiting
16
Lundquist Institute for Biomedical Innovation at Harbor - UCLA Medical Center
Torrance, California, United States, 90502
Actively Recruiting
17
Rocky Mountain Regional VA Medical Center
Aurora, Colorado, United States, 80045
Actively Recruiting
18
Cardiology Associates of Fairfield County, P.C
Bridgeport, Connecticut, United States, 06606
Actively Recruiting
19
Hartford Hospital
Hartford, Connecticut, United States, 06102
Actively Recruiting
20
Yale New Haven Health Heart & Vascular Center Outpatient Services
New Haven, Connecticut, United States, 06519
Actively Recruiting
21
CHF Heart Clinical (Subject Visits & IP Shipments)
Clearwater, Florida, United States, 33756
Actively Recruiting
22
Holy Cross Medical Group - Cardiology Associates
Fort Lauderdale, Florida, United States, 33308
Actively Recruiting
23
South Florida Research Solutions, LLC
Hollywood, Florida, United States, 33351
Actively Recruiting
24
UF Health Jacksonville
Jacksonville, Florida, United States, 32209
Actively Recruiting
25
Broward Research Center
Miami Beach, Florida, United States, 33140
Actively Recruiting
26
Ocala Cardiovascular Research
Ocala, Florida, United States, 34471
Actively Recruiting
27
AdventHealth
Orlando, Florida, United States, 32803
Actively Recruiting
28
USF Health South Tampa Center for Advanced Healthcare
Tampa, Florida, United States, 33606
Actively Recruiting
29
Grady Health System
Atlanta, Georgia, United States, 30303
Actively Recruiting
30
Piedmont Atlanta Hospital
Atlanta, Georgia, United States, 30309
Actively Recruiting
31
Emory Clinic
Atlanta, Georgia, United States, 30322
Actively Recruiting
32
Piedmont Fayette Hospital
Fayetteville, Georgia, United States, 30214
Actively Recruiting
33
The Queen's Medical Center - Punchbowl
Honolulu, Hawaii, United States, 96813
Actively Recruiting
34
Midwest Cardiovascular Institute
Naperville, Illinois, United States, 60540
Actively Recruiting
35
Cardiovascular Research of Northwest Indiana, LLC.
Munster, Indiana, United States, 46321
Actively Recruiting
36
Deaconess Heart Group
Newburgh, Indiana, United States, 47630
Actively Recruiting
37
Reid Physician Associates
Richmond, Indiana, United States, 47374
Actively Recruiting
38
The University of Kansas Medical Center
Kansas City, Kansas, United States, 66160
Actively Recruiting
39
AHMG Cardiology and Surgery
Overland Park, Kansas, United States, 66211
Actively Recruiting
40
University Medical Center New Orleans
New Orleans, Louisiana, United States, 70112
Actively Recruiting
41
Eastern Main Medical Center dba Northern Light Eastern Maine Medical Center
Bangor, Maine, United States, 04401
Actively Recruiting
42
University of Maryland Medical Center
Baltimore, Maryland, United States, 21201
Actively Recruiting
43
Tufts Medical Center
Boston, Massachusetts, United States, 02111
Actively Recruiting
44
Henry Ford Hospital
Detroit, Michigan, United States, 48202
Actively Recruiting
45
Midwest Heart and Vascular Specialists, LLC
Independence, Missouri, United States, 64057
Actively Recruiting
46
Saint Luke's Hospital of Kansas City
Kansas City, Missouri, United States, 64111
Actively Recruiting
47
Washington University Center for Advanced Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
48
St. Louis Heart and Vascular
St Louis, Missouri, United States, 63136
Withdrawn
49
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
Actively Recruiting
50
Advanced Heart Care, LLC
Bridgewater, New Jersey, United States, 08807
Actively Recruiting
51
Monmouth Cardiology Associates, LLC
Eatontown, New Jersey, United States, 07724
Actively Recruiting
52
Capital Cardiology Associates
Albany, New York, United States, 12205
Actively Recruiting
53
Northwell Health North Shore University Hospital
Manhasset, New York, United States, 11030
Actively Recruiting
54
Mount Sinai Hospital
New York, New York, United States, 10029
Actively Recruiting
55
Columbia University Medical Center / New York - Presbyterian
New York, New York, United States, 10032
Actively Recruiting
56
Montefiore Medical Center (Moses Campus)
The Bronx, New York, United States, 10467
Actively Recruiting
57
WakeMed Heart & Vascular - Cary Cardiology
Cary, North Carolina, United States, 27518
Actively Recruiting
58
Clinical and Translational Research Center - University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States, 27599-7064
Actively Recruiting
59
Duke University Hospital
Durham, North Carolina, United States, 27710
Actively Recruiting
60
Moses H. Cone Memorial Hospital Operating Corporation d/b/a Cone Health
Greensboro, North Carolina, United States, 27401
Actively Recruiting
61
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157
Actively Recruiting
62
The Lindner Research Center at the Christ Hospital
Cincinnati, Ohio, United States, 45219
Actively Recruiting
63
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States, 44106
Actively Recruiting
64
Cleveland Clinic
Cleveland, Ohio, United States, 44195
Actively Recruiting
65
K&R Research LLC
Marion, Ohio, United States, 43302
Withdrawn
66
University of Hospitals North Ohio Heart
Sandusky, Ohio, United States, 44870
Actively Recruiting
67
Oklahoma State University Center for Health Sciences
Tulsa, Oklahoma, United States, 74127
Actively Recruiting
68
Oregon Health and Science University
Portland, Oregon, United States, 97239
Actively Recruiting
69
Capital Area Research, LLC
Camp Hill, Pennsylvania, United States, 17011
Actively Recruiting
70
Penn State Health Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States, 17033
Actively Recruiting
71
Hospital of the University of Pennsylvania (University of Pennsylvania School of Medicine)
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
72
Medical University of South Carolina - Gazes Research Institute
Charleston, South Carolina, United States, 29425
Actively Recruiting
73
Monument Health Clinical Research, a department of Monument Health Rapid City Hospital, Inc.
Rapid City, South Dakota, United States, 57701
Actively Recruiting
74
Stern Cardiovascular Foundation, Inc.
Germantown, Tennessee, United States, 38138
Actively Recruiting
75
Tennova Healthcare-Turkey Creek Medical Center
Knoxville, Tennessee, United States, 37934
Actively Recruiting
76
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
77
Tennessee Center for Clinical Trials
Tullahoma, Tennessee, United States, 37388
Actively Recruiting
78
Baylor University Medical Center
Dallas, Texas, United States, 75246
Actively Recruiting
79
The University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390
Actively Recruiting
80
Medresearch Inc
El Paso, Texas, United States, 79902
Actively Recruiting
81
University of Texas Medical Branch - UTMB
Galveston, Texas, United States, 77555
Actively Recruiting
82
CHI St. Luke's Health Baylor College of Medicine Medical Center
Houston, Texas, United States, 77030
Actively Recruiting
83
Baylor Scott & White Medical Center- The Hearth Hospital
Plano, Texas, United States, 75093
Actively Recruiting
84
Intermountain Medical Center
Murray, Utah, United States, 84107
Actively Recruiting
85
University of Utah Health
Salt Lake City, Utah, United States, 84132
Actively Recruiting
86
Sentara Norfolk General Hospital
Norfolk, Virginia, United States, 23507
Actively Recruiting
87
Providence Advanced Heart Disease and Transplant
Spokane, Washington, United States, 99204
Actively Recruiting
88
Medical College of Wisconsin / Froedtert Hospital
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
89
Mazankowski Alberta Heart Institute / University of Alberta Hospital
Edmonton, Alberta, Canada, T6G2B7
Actively Recruiting
90
Kelowna General Hospital
Kelowna, British Columbia, Canada, V1Y1T2
Actively Recruiting
91
SMH - Cardiology Clinical Trials Inc.
Surrey, British Columbia, Canada, V3V0C6
Actively Recruiting
92
St. Paul's Hospital
Vancouver, British Columbia, Canada, V6Z1Y6
Actively Recruiting
93
Victoria Heart Institute Foundation
Victoria, British Columbia, Canada, V8R1B2
Actively Recruiting
94
St. Boniface Hospital
Winnipeg, Manitoba, Canada, R2H2A6
Actively Recruiting
95
Kingston Health Sciences Centre
Kingston, Ontario, Canada, K7L 2V7
Actively Recruiting
96
London Health Sciences Centre
London, Ontario, Canada, N6A5A5
Actively Recruiting
97
Oakville Trafalgar Memorial Hospital - Halton Healthcare
Oakville, Ontario, Canada, L6M0L8
Actively Recruiting
98
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N1J7
Actively Recruiting
99
St. Michael's Hospital
Toronto, Ontario, Canada, M5B1W8
Actively Recruiting
100
UHN-Toronto General Hospital
Toronto, Ontario, Canada, M5G2C4
Actively Recruiting
101
Montreal Heart Institute
Montreal, Quebec, Canada, H1T1C8
Actively Recruiting
102
Diex Recherche Sherbrooke
Sherbrooke, Quebec, Canada, J1L0H8
Actively Recruiting
103
CISSSL - Hopital Pierre-Le Gardeur
Terrebonne, Quebec, Canada, J6V 2H2
Actively Recruiting
104
Centre Hospitalier Universitaire de Toulouse
Toulouse, Haute-Garonne, France, 31059
Actively Recruiting
105
Polyclinique Vauban
Valenciennes, Hauts-de-France, France, 59300
Actively Recruiting
106
CHU de Rennes - Hôpital Pontchaillou
Rennes, Ille-et-Vilaine, France, 35033
Actively Recruiting
107
Centre Hospitalier Universitaire Grenoble Alpes - Site Nord Michallon
La Tronche, Isère, France, 38700
Actively Recruiting
108
CHU de Montpellier- Hôpital Arnaud de Villeneuve
Montpellier, Occitanie, France, 34295
Actively Recruiting
109
L'Hôpital Privé Du Confluent
Nantes, Pays de la Loire Region, France, 44277
Actively Recruiting
110
Centre Hospitalier Intercommunal Toulon - La Seyne sur Mer (C.H.I.T.S)
Toulon, Var, France, 83100
Actively Recruiting
111
Hôpital Lariboisière - APHP
Paris, Île-de-France Region, France, 75010
Actively Recruiting
112
Hôpital Européen Georges Pompidou
Paris, Île-de-France Region, France, 75015
Actively Recruiting
113
APHP - Hôpital Bichât
Paris, Île-de-France Region, France, 75018
Actively Recruiting
114
Heidelberg University Hospital, Clinic for Cardiology, Angiology and Pneum
Heidelberg, Baden-Wurttemberg, Germany, 69120
Actively Recruiting
115
LMU Klinikum - Medizinische Klinik und Poliklinik I
München, Bavaria, Germany, 81377
Actively Recruiting
116
Universitätsklinik Würzburg Deutsches Zentrum für Herzinsuffizienz
Würzburg, Bavaria, Germany, 97078
Actively Recruiting
117
UKE, Klinik fur Kardiologie
Hamburg, Free and Hanseatic City of Hamburg, Germany, 20246
Actively Recruiting
118
UKE, Klinik für Kardiologie
Hamburg, Free and Hanseatic City of Hamburg, Germany, 20246
Actively Recruiting
119
Helios Klinikum Erfurt GmbH
Erfurt, Germany, Germany, 99089
Actively Recruiting
120
Universitaetsklinikum Jena
Jena, Germany, Germany, 07747
Actively Recruiting
121
Marienhaus Klinikum Mainz GmbH
Mainz, Germany, Germany, 55131
Actively Recruiting
122
Kerckhoff-Klinik GmbH
Bad Nauheim, Hesse, Germany, 61231
Actively Recruiting
123
Universitaetsklinikum Frankfurt, Med. Klinik III - Kardiologie, Angiologie
Frankfurt am Main, Hesse, Germany, 60590
Actively Recruiting
124
Asklepios Klinik Langen-Seligenstadt GmbH
Langen, Hesse, Germany, 63225
Actively Recruiting
125
Universitaetsmedizin Goettingen
Göttingen, Lower Saxony, Germany, 37075
Actively Recruiting
126
Universitätsklinikum Bonn
Bonn, North Rhine-Westphalia, Germany, 53127
Actively Recruiting
127
Dr. med. Jens Taggeselle
Markkleeberg, Saxony, Germany, 04416
Actively Recruiting
128
General Hospital of Athens ''G. Gennimatas''
Athens, Attica, Greece, 11527
Actively Recruiting
129
General Hospital of Athens ''Hippokratio''
Athens, Attica, Greece, 11527
Actively Recruiting
130
General Hospital of Nea Ionia ''Konstantopouleio-Patision''
Athens, Attica, Greece, 14233
Actively Recruiting
131
University General Hospital ''ATTIKON'' - General Hospital of West Attica H
Chaïdári, Attica, Greece, 12462
Actively Recruiting
132
General Hospital ''Asklepieio Voulas''
Voula, Attica, Greece, 16673
Actively Recruiting
133
General Hospital of Chalkida
Chalcis, Euboea, Greece, 34100
Actively Recruiting
134
University General Hospital of Alexandroupolis
Alexandroupoli, Evros, Greece, 68100
Actively Recruiting
135
University General Hospital of Larissa
Larissa, Larissa, Greece, 41110
Actively Recruiting
136
Papageorgiou General Hospital of Thessaloniki
Efkarpia, Thessaloniki, Greece, 56403
Actively Recruiting
137
AHEPA University General Hospital of Thessaloniki
Thessaloniki, Thessaloniki, Greece, 54636
Actively Recruiting
138
ASST Spedali Civili di Brescia
Brescia, BS, Italy, 25123
Actively Recruiting
139
Ospedale Infermi
Rimini, Emilia-Romagna, Italy, 47923
Actively Recruiting
140
Ospedale di Arzignano
Arzignano, Lombardy, Italy, 36071
Actively Recruiting
141
ASST Papa Giovanni XXIII
Bergamo, Lombardy, Italy, 24127
Actively Recruiting
142
Centro Cardiologico Monzino
Milan, Lombardy, Italy, 20138
Actively Recruiting
143
IRCCS Multimedica
Sesto San Giovanni, Lombardy, Italy, 20099
Actively Recruiting
144
IRCCS Ospedale San Raffaele
Milan, MI, Italy, 20132
Actively Recruiting
145
A.O. Perugia - Ospedale S.Maria della Misericordia
Perugia, Province of Perugia, Italy, 06129
Actively Recruiting
146
Azienda Ospedaliero-Universitaria di Ferrara - Arcispedale Sant' Anna
Cona, Italy, 44124
Actively Recruiting
147
IRCCS San Raffaele
Roma, Italy, 00163
Actively Recruiting
148
Balsammedica Sp. z o.o.
Warsaw, Masovian Voivodeship, Poland, 01249
Actively Recruiting
149
Centralny Szpital Kliniczny UCK WUM
Warsaw, Masovian Voivodeship, Poland, 02-097
Actively Recruiting
150
Uniwersytecki Szpital Kliniczny w Bialymstoku
Bialystok, Poland, 15276
Actively Recruiting
151
Krakowski Szpital Specjalistyczny im. Sw. Jana Pawla II
Krakow, Poland, 31202
Actively Recruiting
152
SPZOZ Uniwersytecki Szpital Kliniczny nr 2 UM w Lodzi
Lodz, Poland, 90549
Actively Recruiting
153
SPZOZ Centralny Szpital Kliniczny UM w Lodzi
Lodz, Poland, 92213
Actively Recruiting
154
Szpital Sw. Anny w Miechowie
Miechów, Poland, 32200
Actively Recruiting
155
Uniwersytecki Szpital Kliniczny w Opolu
Opole, Poland, 45401
Actively Recruiting
156
Uniwersytecki Szpital Kliniczny w Poznaniu
Poznan, Poland, 61848
Actively Recruiting
157
Poradnia AKA-MED Centrum Sp. z o.o.
Ruda Śląska, Poland, 41710
Actively Recruiting
158
Tomasz Blicharski Lubelskie Centrum Diagnostyczne
Świdnik, Poland, 21040
Actively Recruiting
159
Wojewodzki Szpital Zespolony im. L. Rydygiera
Torun, Poland, 87100
Actively Recruiting
160
Hospital Universitario A Coruña
A Coruña, A Coruña, Spain, 15006
Actively Recruiting
161
Hospital Clinico Universitario de Santiago
Santiago de Compostela, A Coruña, Spain, 15706
Actively Recruiting
162
Hospital de la Santa Creu i Sant Pau
Barcelona, Barcelona, Spain, 08025
Actively Recruiting
163
Hospital Universitari Vall d'Hebron
Barcelona, Barcelona, Spain, 08035
Actively Recruiting
164
Hospital Universitari de Bellvitge
L'Hospitalet de Llobregat, Barcelona, Spain, 08907
Actively Recruiting
165
Hospital San Juan de la Cruz
Úbeda, Jaen, Spain, 23400
Actively Recruiting
166
Hospital Universitario Lucus Augusti
Lugo, Lugo, Spain, 27003
Actively Recruiting
167
Hospital Universitario 12 de Octubre
Madrid, Madrid, Spain, 28041
Actively Recruiting
168
Hospital Universitario La Paz
Madrid, Madrid, Spain, 28046
Actively Recruiting
169
Hospital Universitario Puerta de Hierro
Majadahonda, Madrid, Spain, 28222
Actively Recruiting
170
Hospital Universitario Virgen de La Arrixaca
El Palmar, Murcia, Spain, 30120
Actively Recruiting
171
CHUVI - H.U. Alvaro Cunqueiro
Vigo, Pontevedra, Spain, 36312
Actively Recruiting
172
Hospital Universitario de Salamanca
Salamanca, Salamanca, Spain, 37007
Actively Recruiting
173
Hospital Universitario Virgen del Rocío
Seville, Sevilla, Spain, 41013
Actively Recruiting
174
Hospital Universitari Joan XXIII de Tarragona
Tarragona, Tarragona, Spain, 43005
Actively Recruiting
175
Hospital Clínico Universitario de Valencia
Valencia, Valencia, Spain, 46010
Actively Recruiting
176
Hospital Universitari i Politecnic La Fe de Valencia
Valencia, Valencia, Spain, 46026
Actively Recruiting
177
Harefield Hospital
Harefield, Greater London, United Kingdom, UB96JH
Actively Recruiting
178
Southampton General Hospital
Southampton, Hampshire, United Kingdom, SO166YD
Actively Recruiting
179
Queen Elizabeth University Hospital
Glasgow, Scotland, United Kingdom, G514TF
Actively Recruiting
180
Basingstoke and North Hampshire Hospital
Basingstoke, United Kingdom, RG249NA
Actively Recruiting
181
Castle Hill Hospital
Cottingham, United Kingdom, HU165JQ
Actively Recruiting
182
Russells Hall Hospital
Dudley, United Kingdom, DY12HQ
Actively Recruiting
183
Ulster Hospital
Dundonald, United Kingdom, BT161RH
Actively Recruiting
184
Glasgow Royal Infirmary
Glasgow, United Kingdom, G40SF
Actively Recruiting
185
Great Western Hospitals
Swindon, United Kingdom, SN36BB
Actively Recruiting
Research Team
C
Cytokinetics MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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