Actively Recruiting
Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)
Led by Merck Sharp & Dohme LLC · Updated on 2026-05-05
1310
Participants Needed
282
Research Sites
319 weeks
Total Duration
On this page
Sponsors
M
Merck Sharp & Dohme LLC
Lead Sponsor
O
Orion Corporation, Orion Pharma
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a phase 3, randomized, open-label study of opevesostat compared to alternative abiraterone acetate or enzalutamide in participants with metastatic castration-resistant prostate cancer (mCRPC) with respect to overall survival (OS) in participants with mCRPC previously treated with next-generation hormonal agent (NHA) and taxane-based chemotherapy. It is hypothesized that opevesostat is superior with respect to OS in androgen receptor ligand binding domain (AR LBD) mutation-negative and -positive participants.
CONDITIONS
Official Title
Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically or cytologically confirmed prostate adenocarcinoma without small cell features
- Prostate cancer progression while on androgen deprivation therapy or after bilateral orchiectomy within 6 months before screening
- Evidence of distant metastases shown by bone scan or CT/MRI
- Disease progression during or after treatment with one novel hormonal agent (NHA)
- Received one or two taxane-based chemotherapy regimens for mCRPC with progressive disease during or after treatment
- Ongoing androgen deprivation with serum testosterone below 50 ng/dL (1.7 nM)
- Provided tumor tissue from a recent biopsy of soft tissue not previously irradiated
- Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 within 7 days of randomization
- Prior treatment with PARP inhibitors or deemed ineligible or refused PARP inhibitor treatment
- Prior treatment with 177Lu-PSMA-617 or deemed ineligible or refused this treatment
- If not treated with cabazitaxel, ineligible for or refused cabazitaxel treatment
- If received first-generation anti-androgen therapy before screening, evidence of disease progression more than 4 weeks since last flutamide and more than 6 weeks since last bicalutamide or nilutamide
- Stable dose of bone resorptive therapy for at least 4 weeks before randomization
- Participants with HIV must have well-controlled infection on antiretroviral therapy
- Participants positive for hepatitis B surface antigen must have received antiviral therapy for at least 4 weeks and have undetectable viral load before randomization
- Participants with history of hepatitis C infection must have undetectable viral load at screening
- Participants who can produce sperm must agree to use male condom or be abstinent during and after study treatment as specified
You will not qualify if you...
- Gastrointestinal disorders that may affect drug absorption
- History of pituitary dysfunction
- Poorly controlled diabetes mellitus
- Clinically significant abnormal potassium or sodium levels
- History of active or unstable cardiovascular or cerebrovascular disease, including thromboembolic events
- History of seizures within 6 months or conditions predisposing to seizures within 12 months before randomization
- History of significant ventricular arrhythmias
- Recent anticancer monoclonal antibody treatment within 4 weeks or unresolved adverse events from prior monoclonal antibodies
- Major surgery or prostate interventions within 28 days before randomization without full recovery
- Use of herbal or medicinal products known to affect prostate cancer or PSA within 4 weeks before randomization
- Recent treatment with radium-223 or lutetium-177 within 4 weeks or unresolved adverse events from prior treatment
- Use of 5-alpha reductase inhibitors, estrogens, or cyproterone within 4 weeks before randomization
- Use of colony-stimulating factors within 28 days before randomization
- Recent whole blood transfusion within 120 days or platelet/red blood cell transfusions within 28 days
- Prior targeted small molecule or NHA treatment within specified weeks before first study dose
- Superscan bone scan
- Diagnosis of immunodeficiency or recent systemic steroid or immunosuppressive therapy
- Additional progressing malignancy requiring treatment in past 3 years
- Active central nervous system metastases or carcinomatous meningitis
- Active autoimmune disease treated systemically in past 2 years
- Active infection requiring systemic therapy
- Concurrent active hepatitis B or known active hepatitis C infection
- History of long QTc syndrome
- Hypotension or uncontrolled hypertension as defined at screening
- Inability to swallow capsules or tablets
- Current treatment with cytochrome 450-inducing antiepileptic drugs
- Unstable thyroid hormone therapy within 6 months before study
- Recent systemic anticancer therapy or investigational agents within 4 weeks before first dose
- Recent radiotherapy within 2 weeks or radiation-related toxicities requiring corticosteroids
- Live or live-attenuated vaccine within 30 days before first dose
- Recent use of strong CYP3A4 inducers or P-gp inhibitors within 2 weeks before first dose
- Use of aldosterone antagonists or phenytoin within 4 weeks before study start
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 282 locations
1
University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 0040)
Orange, California, United States, 92868
Active, Not Recruiting
2
Stanford Cancer Center ( Site 0036)
Palo Alto, California, United States, 94304
Actively Recruiting
3
Kaiser Permanente Riverside Medical Center ( Site 0099)
Riverside, California, United States, 92505
Actively Recruiting
4
Anschutz Cancer Pavilion ( Site 0046)
Aurora, Colorado, United States, 80045
Actively Recruiting
5
University of Colorado Health - Highlands Ranch Hospital ( Site 0111)
Highlands Ranch, Colorado, United States, 80129
Actively Recruiting
6
Colorado Clinical Research ( Site 0067)
Lakewood, Colorado, United States, 80228
Active, Not Recruiting
7
University of Colorado Health - Lone Tree Medical Center ( Site 0112)
Lone Tree, Colorado, United States, 80124
Actively Recruiting
8
Yale-New Haven Hospital-Yale Cancer Center ( Site 0064)
New Haven, Connecticut, United States, 06510
Actively Recruiting
9
Florida Cancer Specialists - South ( Site 7003)
Fort Myers, Florida, United States, 33901
Actively Recruiting
10
Bruce W. Carter Veterans Affairs Medical Center ( Site 0082)
Miami, Florida, United States, 33125
Active, Not Recruiting
11
University of Miami Hospital and Clinics, Sylvester Cancer Center ( Site 0051)
Miami, Florida, United States, 33136
Actively Recruiting
12
University of Illinois at Chicago ( Site 0105)
Chicago, Illinois, United States, 60612
Actively Recruiting
13
University of Chicago Medical Center ( Site 0045)
Chicago, Illinois, United States, 60637
Actively Recruiting
14
University of Iowa ( Site 0047)
Iowa City, Iowa, United States, 52242
Actively Recruiting
15
University of Kentucky Chandler Medical Center ( Site 0048)
Lexington, Kentucky, United States, 40536
Active, Not Recruiting
16
Ochsner Clinic Foundation ( Site 0108)
New Orleans, Louisiana, United States, 70121
Active, Not Recruiting
17
Baltimore Veterans Affairs Medical Center ( Site 0069)
Baltimore, Maryland, United States, 21201
Actively Recruiting
18
Greenebaum Comprehensive Cancer Center ( Site 0049)
Baltimore, Maryland, United States, 21201
Actively Recruiting
19
Henry Ford Hospital ( Site 0015)
Detroit, Michigan, United States, 48202
Active, Not Recruiting
20
M Health Fairview Clinics and Surgery Center ( Site 0019)
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
21
Metro-Minnesota Community Clinical Oncology ( Site 0014)
Saint Louis Park, Minnesota, United States, 55416
Actively Recruiting
22
Washington University School of Medicine-Internal Medicine/Oncology ( Site 0062)
St Louis, Missouri, United States, 63110
Active, Not Recruiting
23
University Of Nebraska Medical Center-Oncology/Hematology ( Site 0095)
Omaha, Nebraska, United States, 68105
Actively Recruiting
24
Comprehensive Cancer Centers of Nevada ( Site 0010)
Las Vegas, Nevada, United States, 89148
Actively Recruiting
25
Atlantic Health System Morristown Medical Center ( Site 0115)
Morristown, New Jersey, United States, 07960
Actively Recruiting
26
Rutgers Cancer Institute of New Jersey ( Site 0033)
New Brunswick, New Jersey, United States, 08901
Active, Not Recruiting
27
James J. Peters VA Medical Center ( Site 0088)
The Bronx, New York, United States, 10468
Actively Recruiting
28
University Hospitals Cleveland Medical Center ( Site 0043)
Cleveland, Ohio, United States, 44106
Actively Recruiting
29
Oregon Health and Science University ( Site 0028)
Portland, Oregon, United States, 97239
Active, Not Recruiting
30
VA Portland Health Care System ( Site 0058)
Portland, Oregon, United States, 97239
Actively Recruiting
31
AHN Allegheny General Hospital ( Site 0001)
Pittsburgh, Pennsylvania, United States, 15212
Active, Not Recruiting
32
Ralph H. Johnson VA Health Care System (RHJVAHCS)-Urology ( Site 0083)
Charleston, South Carolina, United States, 29401
Active, Not Recruiting
33
Avera Cancer Institute - Pierre ( Site 0118)
Pierre, South Dakota, United States, 57501
Actively Recruiting
34
Avera Cancer Institute- Research ( Site 0094)
Sioux Falls, South Dakota, United States, 57105
Actively Recruiting
35
Avera Cancer Institute - Yankton ( Site 0117)
Yankton, South Dakota, United States, 57078
Actively Recruiting
36
SCRI Oncology Partners ( Site 7000)
Nashville, Tennessee, United States, 37203
Actively Recruiting
37
Texas Oncology - Central/South Texas ( Site 8003)
Austin, Texas, United States, 78731
Actively Recruiting
38
Texas Oncology - DFW ( Site 8001)
Dallas, Texas, United States, 75246
Active, Not Recruiting
39
Texas Oncology - Gulf Coast ( Site 8002)
The Woodlands, Texas, United States, 77380
Actively Recruiting
40
University of Virginia Health System ( Site 0054)
Charlottesville, Virginia, United States, 22908
Actively Recruiting
41
VCU Health Adult Outpatient Pavillion ( Site 0061)
Richmond, Virginia, United States, 23219
Active, Not Recruiting
42
Blue Ridge Cancer Care ( Site 0004)
Roanoke, Virginia, United States, 24014
Actively Recruiting
43
Fred Hutchinson Cancer Center ( Site 0013)
Seattle, Washington, United States, 98109
Actively Recruiting
44
MEDICAL COLLEGE OF WISCONSIN ( Site 0020)
Milwaukee, Wisconsin, United States, 53226
Actively Recruiting
45
Hospital Británico de Buenos Aires-Oncology ( Site 0202)
Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, C1280AEB
Actively Recruiting
46
Instituto de Investigaciones Clínicas Mar del Plata ( Site 0201)
Mar del Plata, Buenos Aires, Argentina, B7600FZO
Actively Recruiting
47
Instituto Alexander Fleming-Alexander Fleming ( Site 0206)
Buenos Aires, Buenos Aires F.D., Argentina, 1426ANZ
Actively Recruiting
48
Asociación de Beneficencia Hospital Sirio Libanés ( Site 0205)
Buenos Aires, Buenos Aires F.D., Argentina, C1419AHN
Actively Recruiting
49
Sanatorio Parque ( Site 0208)
Rosario, Santa Fe Province, Argentina, S2000DVC
Actively Recruiting
50
Hospital Aleman-Oncology ( Site 0207)
Buenos Aires, Argentina, C1118AAT
Actively Recruiting
51
Fundacion Centro Oncologico de Integración Regional-Medical Oncology ( Site 0204)
Mendoza, Argentina, M5500AYB
Active, Not Recruiting
52
Dubbo Hospital ( Site 0235)
Dubbo, New South Wales, Australia, 2830
Actively Recruiting
53
Macquarie University-MQ Health Clinical Trials Unit ( Site 0234)
Macquarie University, New South Wales, Australia, 2109
Actively Recruiting
54
Westmead Hospital ( Site 0232)
Westmead, New South Wales, Australia, 2145
Active, Not Recruiting
55
Princess Alexandra Hospital-Cancer Care Serices ( Site 0237)
Brisbane, Queensland, Australia, 4102
Actively Recruiting
56
Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 0230)
Melbourne, Victoria, Australia, 3000
Active, Not Recruiting
57
Medizinische Universität Graz-Innere Medizin Klin. Abt. Onkologie ( Site 0280)
Graz, Styria, Austria, 8036
Actively Recruiting
58
Ordensklinikum Linz GmbH Elisabethinen-Urologie ( Site 0276)
Linz, Upper Austria, Austria, 4020
Actively Recruiting
59
Klinikum Wels-Grieskirchen GmbH ( Site 0279)
Wels, Upper Austria, Austria, 4600
Actively Recruiting
60
Hospital Santa Rita de Cassia-Centro de Pesquisa Clínica ( Site 0320)
Vitória, Espírito Santo, Brazil, 29041-295
Actively Recruiting
61
Obras Sociais Irma Dulce ( Site 0302)
Salvador, Estado de Bahia, Brazil, 40415-006
Active, Not Recruiting
62
Hospital Felicio Rocho ( Site 0317)
Belo Horizonte, Minas Gerais, Brazil, 30110-934
Actively Recruiting
63
Hospital Mario Penna ( Site 0309)
Belo Horizonte, Minas Gerais, Brazil, 30380-472
Active, Not Recruiting
64
Hospital Universitário Evangélico Mackenzie-Centro de Oncologia Mackenzie ( Site 0314)
Curitiba, Paraná, Brazil, 80440-220
Active, Not Recruiting
65
Clínica de Neoplasias Litoral ( Site 0305)
Itajaí, Santa Catarina, Brazil, 88301-220
Actively Recruiting
66
Hospital Universitário São Francisco de Assis - Bragança Paulista ( Site 0308)
Bragança Paulista, São Paulo, Brazil, 12916-542
Active, Not Recruiting
67
A. C. Camargo Cancer Center ( Site 0310)
São Paulo, São Paulo, Brazil, 01509-010
Active, Not Recruiting
68
Cross Cancer Institute ( Site 0332)
Edmonton, Alberta, Canada, T6G 1Z2
Actively Recruiting
69
The Ottawa Hospital - General Campus-The Ottawa Hospital Cancer Centre ( Site 0336)
Ottawa, Ontario, Canada, K1H 8L6
Actively Recruiting
70
Sunnybrook Research Institute ( Site 0331)
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
71
Princess Margaret Cancer Centre ( Site 0330)
Toronto, Ontario, Canada, M5G 2M9
Actively Recruiting
72
Centre Intégré de Santé et de Services Sociaux de la Montérégie-Centre ( Site 0328)
Greenfield Park, Quebec, Canada, J4V 2H1
Actively Recruiting
73
Centre Hospitalier de l'Université de Montréal ( Site 0326)
Montreal, Quebec, Canada, H2X 3E4
Active, Not Recruiting
74
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0327)
Québec, Quebec, Canada, G1J 1Z4
Actively Recruiting
75
Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer ( Site 0329)
Sherbrooke, Quebec, Canada, J1H 5H4
Active, Not Recruiting
76
IC La Serena Research ( Site 0356)
La Serena, Coquimbo Region, Chile, 1720430
Active, Not Recruiting
77
Clinical Research Chile SpA ( Site 0358)
Valdivia, Los Ríos Region, Chile, 5110683
Active, Not Recruiting
78
Clinica Universidad Catolica del Maule-Oncology ( Site 0355)
Talca, Maule Region, Chile, 3465584
Actively Recruiting
79
FALP ( Site 0353)
Santiago, Region M. de Santiago, Chile, 7500921
Active, Not Recruiting
80
Pontificia Universidad Catolica de Chile-Hemato-Oncology ( Site 0354)
Santiago, Region M. de Santiago, Chile, 8330024
Actively Recruiting
81
Bradfordhill-Clinical Area ( Site 0351)
Santiago, Region M. de Santiago, Chile, 8420383
Actively Recruiting
82
Bradford Hill Norte ( Site 0357)
Antofagasta, Chile, 1240000
Active, Not Recruiting
83
Second Affiliated hospital of Anhui Medical University-Urology ( Site 0408)
Hefei, Anhui, China, 230000
Actively Recruiting
84
Peking University First Hospital-Urology ( Site 0390)
Beijing, Beijing Municipality, China, 100034
Actively Recruiting
85
Beijing Friendship Hospital Affiliate of Capital University ( Site 0396)
Beijing, Beijing Municipality, China, 100050
Actively Recruiting
86
Beijing Cancer hospital-Urinary Surgery ( Site 0395)
Beijing, Beijing Municipality, China, 100142
Actively Recruiting
87
The First Affiliated Hospital of Chongqing Medical University ( Site 0427)
Chongqing, Chongqing Municipality, China, 400010
Actively Recruiting
88
Chongqing University Cancer Hospital ( Site 0416)
Chongqing, Chongqing Municipality, China, 400030
Actively Recruiting
89
Southwest Hospital of Third Military Medical University ( Site 0420)
Chongqing, Chongqing Municipality, China, 400038
Actively Recruiting
90
Chongqing Three Gorges Central Hospital's ( Site 0426)
Chongqing, Chongqing Municipality, China, 404100
Actively Recruiting
91
The First Affiliated Hospital Of Fujian Medical University-Urology ( Site 0414)
Fuzhou, Fujian, China, 350005
Actively Recruiting
92
The First Affiliated hospital of Xiamen University-Urology ( Site 0415)
Xiamen, Fujian, China, 361003
Actively Recruiting
93
The First Affiliated Hospital of Guangzhou Medical University ( Site 0412)
Guangzhou, Guangdong, China, 510120
Actively Recruiting
94
Sun Yat-sen University Cancer Center-Internal medicine ( Site 0413)
Guangzhou, Guangdong, China, 511400
Actively Recruiting
95
Tongji Hospital Tongji Medical,Science & Technology ( Site 0407)
Wuhan, Hubei, China, 430000
Actively Recruiting
96
Hubei Cancer Hospital-Urinary surgery ( Site 0406)
Wuhan, Hubei, China, 430079
Actively Recruiting
97
Hunan Cancer Hospital ( Site 0405)
Changsha, Hunan, China, 410013
Actively Recruiting
98
First Huai'an Hospital Affiliated to Nanjing Medical University ( Site 0436)
Huaian, Jiangsu, China, 223300
Actively Recruiting
99
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Urology ( Site 0377)
Nanjing, Jiangsu, China, 210008
Actively Recruiting
100
Affiliated hospital of Jiangnan university ( Site 0434)
Wuxi, Jiangsu, China, 214122
Actively Recruiting
101
Jiangxi Cancer Hospital ( Site 0386)
Nanchang, Jiangxi, China, 330029
Actively Recruiting
102
The Second Affiliated Hospital of Xi'an Jiaotong University ( Site 0394)
Xi'an, Shaanxi, China, 710004
Actively Recruiting
103
The First Affiliated Hospital of Xi'an Jiaotong University-Oncology ( Site 0393)
Xi'an, Shaanxi, China, 710061
Actively Recruiting
104
Yantai Yuhuangding Hospital ( Site 0397)
Yantai, Shandong, China, 264099
Actively Recruiting
105
Zhongshan Hospital of Fudan University (0430)
Shanghai, Shangai, China, 200032
Actively Recruiting
106
Fudan University Shanghai Cancer Center-Urology department ( Site 0376)
Shanghai, Shanghai Municipality, China, 200000
Actively Recruiting
107
Huadong Hospital Affiliated to Fudan University-Urology ( Site 0388)
Shanghai, Shanghai Municipality, China, 200041
Actively Recruiting
108
The Third People's Hospital of Chengdu (CDTPH) ( Site 0428)
Chengdu, Sichuan, China, 500643
Actively Recruiting
109
West China Hospital, Sichuan University-Urology Surgery ( Site 0417)
Chengdu, Sichuan, China, 610041
Actively Recruiting
110
Nanchong Central Hospital-urology ( Site 0422)
Nanchong, Sichuan, China, 500643
Actively Recruiting
111
Suining Central Hospital ( Site 0437)
Suining, Sichuan, China, 629000
Actively Recruiting
112
Tianjin Medical University Cancer Institute & Hospital ( Site 0392)
Tianjin, Tianjin Municipality, China, 300060
Actively Recruiting
113
The Second Hospital of Tianjin Medical University ( Site 0391)
Tianjin, Tianjin Municipality, China, 300211
Actively Recruiting
114
Xinjiang Medical University Cancer Hospital - Urumqi-Urology ( Site 0419)
Ürümqi, Xinjiang, China, 830000
Actively Recruiting
115
The Second Affiliated Hospital Of Kunming Medical University ( Site 0429)
Kunming, Yunnan, China, 650033
Actively Recruiting
116
Yunnan Province Cancer Hospital ( Site 0418)
Kunming, Yunnan, China, 650107
Actively Recruiting
117
Zhejiang Provincial People's Hospital-Urology ( Site 0378)
Hangzhou, Zhejiang, China, 310014
Actively Recruiting
118
Zhejiang Cancer Hospital ( Site 0435)
Hangzhou, Zhejiang, China, 310022
Actively Recruiting
119
The First Hospital of Jiaxing-urology ( Site 0380)
Jiaxing, Zhejiang, China, 314001
Actively Recruiting
120
The First Affiliated Hospital of Ningbo University ( Site 0383)
Ningbo, Zhejiang, China, 315010
Actively Recruiting
121
The First Affiliated Hospital of Wenzhou Medical University-Urology Surgery ( Site 0379)
Wenzhou, Zhejiang, China, 325000
Actively Recruiting
122
Clinica Colsanitas S.A, Sede Clínica Universitaria Colombia-Center Investigator ( Site 0501)
Bogotá, Bogota D.C., Colombia, 111321
Actively Recruiting
123
Sociedad De Oncología y Hematología Del Cesar SAS-Oncology ( Site 0502)
Valledupar, Cesar Department, Colombia, 200001
Actively Recruiting
124
IMAT S.A.S ( Site 0504)
Montería, Departamento de Córdoba, Colombia, 230002
Actively Recruiting
125
Fundación Cardiovascular de Colombia ( Site 0503)
Piedecuesta, Santander Department, Colombia, 681017
Actively Recruiting
126
Fundación Valle del Lili ( Site 0505)
Cali, Valle del Cauca Department, Colombia, 760032
Actively Recruiting
127
Clínica Imbanaco S.A.S ( Site 0509)
Cali, Valle del Cauca Department, Colombia, 760042
Active, Not Recruiting
128
Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 0553)
Brno, Brno-mesto, Czechia, 656 53
Actively Recruiting
129
Fakultni nemocnice Ostrava-Klinika onkologicka ( Site 0554)
Ostrava, Moravian-Silesian Region, Czechia, 708 52
Actively Recruiting
130
Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 0555)
Olomouc, Olomouc Region, Czechia, 779 00
Actively Recruiting
131
Fakultni nemocnice v Motole-Onkologicka klinika 2. LF UK a FN Motol ( Site 0551)
Prague, Praha 5, Czechia, 150 06
Active, Not Recruiting
132
Rigshospitalet ( Site 0576)
Copenhagen, Capital Region, Denmark, 2100
Actively Recruiting
133
Odense Universitetshospital-Department of oncology ( Site 0579)
Odense, Region Syddanmark, Denmark, 5000
Active, Not Recruiting
134
Vejle Sygehus ( Site 0578)
Vejle, Region Syddanmark, Denmark, 7100
Actively Recruiting
135
Kuopion Yliopistollinen Sairaala ( Site 0603)
Kuopio, Northern Savonia, Finland, 70210
Actively Recruiting
136
Tampereen yliopistollinen sairaala ( Site 0604)
Tampere, Pirkanmaa, Finland, 33520
Actively Recruiting
137
Turku University Hospital-Department of Oncology ( Site 0601)
Turku, Southwest Finland, Finland, 20520
Actively Recruiting
138
Centre Oscar Lambret (Site 0634)
Lille, Ain, France, 59020
Actively Recruiting
139
Institut de cancérologie Strasbourg Europe (ICANS) ( Site 0627)
Strasbourg, Alsace, France, 67200
Actively Recruiting
140
Centre Hospitalier Universitaire de Nîmes - Institut de Cancérologie du Gard - Hôpital Universitaire ( Site 0630)
Nîmes, Gard, France, 30029
Active, Not Recruiting
141
Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer ( Site 0632)
Rennes, Ille-et-Vilaine, France, 35042
Actively Recruiting
142
Centre Jean Perrin - Centre Régional de Lutte contre le Cancer d'Auvergne ( Site 0629)
Clermont-Ferrand, Puy-de-Dome, France, 63003
Actively Recruiting
143
Centre Hospitalier de la Côte Basque ( Site 0633)
Bayonne, Pyrenees-Atlantiques, France, 64109
Actively Recruiting
144
Gustave Roussy ( Site 0626)
Villejuif, Val-de-Marne, France, 94800
Actively Recruiting
145
Hôpital Européen Georges Pompidou ( Site 0628)
Paris, France, 75015
Actively Recruiting
146
klinikum rechts der isar der technischen universität münchen-Urologische Klinik und Poliklinik ( Site 0696)
Munich, Bavaria, Germany, 81675
Active, Not Recruiting
147
HELIOS Kliniken Schwerin ( Site 0694)
Schwerin, Mecklenburg-Vorpommern, Germany, 19055
Actively Recruiting
148
Universitätsklinikum Bonn-Klinik und Poliklinik für Urologie und Kinderurologie ( Site 0680)
Bonn, North Rhine-Westphalia, Germany, 53127
Actively Recruiting
149
Universitätsklinikum Münster - Albert Schweitzer Campus-Klinik für Urologie ( Site 0678)
Münster, North Rhine-Westphalia, Germany, 48149
Actively Recruiting
150
Universitätsklinikum Schleswig-Holstein-Klinik für Urologie ( Site 0691)
Lübeck, Schleswig-Holstein, Germany, 23538
Actively Recruiting
151
Universitätsklinikum Jena-Klinik und Poliklinik für Urologie ( Site 0682)
Jena, Thuringia, Germany, 07747
Actively Recruiting
152
Charité Universitaetsmedizin Berlin - Campus Mitte ( Site 0679)
Berlin, Germany, 10117
Actively Recruiting
153
Universitaetsklinikum Hamburg-Eppendorf-Onkologisches Zentrum ( Site 0705)
Hamburg, Germany, 20246
Actively Recruiting
154
Queen Mary Hospital ( Site 0727)
Hong Kong, Hong Kong
Actively Recruiting
155
Prince of Wales Hospital ( Site 0730)
Shatin, Hong Kong
Actively Recruiting
156
Bacs-Kiskun Varmegyei Oktatokorhaz-Onkoradiologiai Kozpont ( Site 0752)
Kecskemét, Bács-Kiskun county, Hungary, 6000
Actively Recruiting
157
Nograd Varmegyei Szent Lazar Korhaz-Onkologia es Sugarterapias Osztaly ( Site 0761)
Salgótarján, Nógrád megye, Hungary, 3100
Actively Recruiting
158
Országos Onkológiai Intézet-Urogenitális Tumorok és Klinikai Farmakológiai Osztály ( Site 0756)
Budapest, Pest County, Hungary, 1122
Actively Recruiting
159
Debreceni Egyetem Klinikai Kozpont-Onkológiai Klinika ( Site 0758)
Debrecen, Hungary, 4032
Actively Recruiting
160
St. Vincent's University Hospital ( Site 0802)
Dublin, Dublin, Ireland, D04 T6F4
Actively Recruiting
161
Tallaght University Hospital ( Site 0801)
Dublin, Ireland, D24 NR0A
Actively Recruiting
162
Emek Medical Center ( Site 0830)
Afula, Israel, 1834111
Actively Recruiting
163
Rambam Health Care Campus-Oncology Division ( Site 0826)
Haifa, Israel, 3109601
Actively Recruiting
164
Hadassah Medical Center ( Site 0833)
Jerusalem, Israel, 9112001
Actively Recruiting
165
Meir Medical Center. ( Site 0832)
Kfar Saba, Israel, 4428164
Actively Recruiting
166
Rabin Medical Center ( Site 0828)
Petah Tikva, Israel, 4941492
Actively Recruiting
167
Sheba Medical Center ( Site 0827)
Ramat Gan, Israel, 5265601
Actively Recruiting
168
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"-Oncologia Medica ( Site 0879)
Meldola, Emilia-Romagna, Italy, 47014
Actively Recruiting
169
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 0877)
Milan, Lombardy, Italy, 20133
Actively Recruiting
170
Ospedale San Raffaele-Oncologia Medica ( Site 0876)
Milan, Italy, 20132
Actively Recruiting
171
Toho University Sakura Medical Center ( Site 0906)
Sakura, Chiba, Japan, 285-8741
Actively Recruiting
172
Ehime University Hospital ( Site 0918)
Tōon, Ehime, Japan, 791-0295
Actively Recruiting
173
Hospital of the University of Occupational and Environmental Health, Japan ( Site 0921)
Kitakyushu, Fukuoka, Japan, 807-8556
Active, Not Recruiting
174
Kurume University Hospital ( Site 0920)
Kurume, Fukuoka, Japan, 830-0011
Actively Recruiting
175
Asahikawa Medical University Hospital ( Site 0901)
Asahikawa, Hokkaido, Japan, 078-8510
Actively Recruiting
176
Sapporo Medical University Hospital ( Site 0902)
Sapporo, Hokkaido, Japan, 060-8543
Actively Recruiting
177
Hokkaido University Hospital ( Site 0931)
Sapporo, Hokkaido, Japan, 060-8648
Actively Recruiting
178
Kobe University Hospital ( Site 0914)
Kobe, Hyōgo, Japan, 650-0017
Actively Recruiting
179
Kanazawa Medical University Hospital ( Site 0909)
Mukai-awagasaki, Ishikawa-ken, Japan, 920-0265
Actively Recruiting
180
Kagawa University Hospital ( Site 0917)
Kita, Kagawa-ken, Japan, 761-0701
Actively Recruiting
181
Yokohama City University Medical Center ( Site 0908)
Yokohama, Kanagawa, Japan, 232-0024
Actively Recruiting
182
National Hospital Organization Nagasaki Medical Center ( Site 0923)
Ōmura, Nagasaki, Japan, 856-8562
Actively Recruiting
183
Nara Medical University Hospital ( Site 0915)
Kashihara, Nara, Japan, 634-8522
Active, Not Recruiting
184
Nanbu Tokushukai Hospital ( Site 0930)
Shimajiri, Okinawa, Japan, 901-0417
Actively Recruiting
185
Kansai Medical University Hospital ( Site 0912)
Hirakata, Osaka, Japan, 573-1191
Actively Recruiting
186
Bell Land General Hospital ( Site 0913)
Sakai, Osaka, Japan, 599-8247
Actively Recruiting
187
The University of Osaka Hospital ( Site 0911)
Suita, Osaka, Japan, 565-0871
Actively Recruiting
188
Saga-Ken Medical Centre Koseikan ( Site 0922)
Saga, Saga-ken, Japan, 840-8571
Active, Not Recruiting
189
The Jikei University Hospital ( Site 0907)
Minato, Tokyo, Japan, 105-8471
Active, Not Recruiting
190
Akita University Hospital ( Site 0904)
Akita, Japan, 010-8543
Actively Recruiting
191
Kyushu University Hospital ( Site 0919)
Fukuoka, Japan, 812-8582
Actively Recruiting
192
Fukushima Medical University Hospital ( Site 0933)
Fukushima, Japan, 960-1295
Actively Recruiting
193
Gifu University Hospital ( Site 0910)
Gifu, Japan, 501-1112
Actively Recruiting
194
Hiroshima University Hospital ( Site 0916)
Hiroshima, Japan, 734-8551
Actively Recruiting
195
Kagoshima University Hospital ( Site 0929)
Kagoshima, Japan, 890-8520
Actively Recruiting
196
National Hospital Organization Kumamoto Medical Center ( Site 0924)
Kumamoto, Japan, 860-0008
Actively Recruiting
197
Miyazaki Prefectural Miyazaki Hospital ( Site 0927)
Miyazaki, Japan, 880-8510
Actively Recruiting
198
University of Miyazaki Hospital ( Site 0926)
Miyazaki, Japan, 889-1692
Actively Recruiting
199
Nagano Municipal Hospital ( Site 0932)
Nagano, Japan, 381-8551
Actively Recruiting
200
National Hospital Organization Oita Medical Center ( Site 0925)
Ōita, Japan, 870-0263
Active, Not Recruiting
201
Hospital Sultan Ismail ( Site 1081)
Johor Bahru, Johor, Malaysia, 81100
Actively Recruiting
202
University Malaya Medical Centre ( Site 1077)
Lembah Pantai, Kuala Lumpur, Malaysia, 59100
Active, Not Recruiting
203
National Cancer Institute ( Site 1079)
Putrajaya, Putrajaya, Malaysia, 62250
Actively Recruiting
204
Sarawak General Hospital-Radiotherapy Unit ( Site 1076)
Kuching, Sarawak, Malaysia, 93586
Actively Recruiting
205
Hospital Kuala Lumpur-Radiotherapy and Oncology ( Site 1078)
Kuala Lumpur, Malaysia, 50586
Actively Recruiting
206
CIO - Centro de Inmuno-Oncología de Occidente ( Site 1103)
Guadalajara, Jalisco, Mexico, 44630
Active, Not Recruiting
207
Quemex Medical and Research ( Site 1112)
Mexico City, Mexico City, Mexico, 14308
Active, Not Recruiting
208
Filios Alta Medicina ( Site 1106)
Monterrey, Nuevo León, Mexico, 64460
Active, Not Recruiting
209
Medical Care and Research SA de CV ( Site 1108)
Mérida, Yucatán, Mexico, 97070
Active, Not Recruiting
210
Centro de Investigacion Clinica de Oaxaca ( Site 1109)
Oaxaca City, Mexico, 68020
Active, Not Recruiting
211
Radboudumc-Medical Oncology ( Site 1152)
Nijmegen, Gelderland, Netherlands, 6525 GA
Actively Recruiting
212
Zuyderland Medical Centre-Trialbureau Interne Geneeskunde ( Site 1163)
Sittard-Geleen, Limburg, Netherlands, 6162 BG
Active, Not Recruiting
213
VieCuri Medisch Centrum ( Site 1173)
Venlo, Limburg, Netherlands, 5912 BL
Active, Not Recruiting
214
ETZ Elisabeth-Internal Medicine ( Site 1160)
Tilburg, North Brabant, Netherlands, 5022 GC
Actively Recruiting
215
Nederlands Kanker Instituut - Antoni van Leeuwenhoek - NKI-AVL ( Site 1153)
Amsterdam, North Holland, Netherlands, 1066 CX
Actively Recruiting
216
Amsterdam UMC, locatie VUmc ( Site 1156)
Amsterdam, North Holland, Netherlands, 1081 HV
Active, Not Recruiting
217
Spaarne Gasthuis - Hoofddorp-Oncology ( Site 1170)
Hoofddorp, North Holland, Netherlands, 2134 TM
Actively Recruiting
218
Medische Centrum Leeuwarden ( Site 1172)
Leeuwarden, Provincie Friesland, Netherlands, 8934 AD
Actively Recruiting
219
Franciscus Gasthuis & Vlietland, Locatie Vlietland ( Site 1151)
Schiedam, South Holland, Netherlands, 3118 JH
Actively Recruiting
220
Haga Ziekenhuis locatie Leyweg-Oncology ( Site 1164)
The Hague, South Holland, Netherlands, 2545 AA
Actively Recruiting
221
Meander Medisch Centrum ( Site 1157)
Amersfoort, Utrecht, Netherlands, 3813TZ
Actively Recruiting
222
Tauranga Hospital-Bay of Plenty Clinical Trials Unit ( Site 1201)
Tauranga, Bay of Plenty, New Zealand, 3112
Actively Recruiting
223
Dunedin Hospital-Southern Blood and Cancers Service ( Site 1203)
Dunedin, Otago, New Zealand, 9016
Actively Recruiting
224
Akershus Universitetssykehus-Onkologisk avdeling ( Site 1227)
Lørenskog, Akershus, Norway, 1474
Actively Recruiting
225
St. Olavs Hospital-Kreftklinikken ( Site 1231)
Trondheim, Sor-Trondelag, Norway, 7030
Active, Not Recruiting
226
Sykehuset Østfold Kalnes ( Site 1228)
Sarpsborg, Østfold fylke, Norway, 1714
Active, Not Recruiting
227
Instituto Regional de Enfermedades Neoplasicas del Centro (IREN CENTRO) ( Site 1258)
Concepción, Departamento de Junín, Peru, 12125
Actively Recruiting
228
Clínica Sánchez Ferrer ( Site 1261)
Trujillo, La Libertad, Peru, 13009
Actively Recruiting
229
Aliada-Oncologìa ( Site 1257)
Lima, Peru, 15036
Active, Not Recruiting
230
IPOR Instituto Peruano de Oncología & Radioterapia-Centro de Investigación ( Site 1254)
Lima, Peru, 15036
Active, Not Recruiting
231
Oncosalud-Clinical Research ( Site 1260)
Lima, Peru, 15036
Active, Not Recruiting
232
INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS-Medical Oncology ( Site 1256)
Lima, Peru, 15038
Actively Recruiting
233
Centrum Onkologii im. Prof. Franciszka Lukaszczyka-Ambulatorium Chemioterapii ( Site 1302)
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-796
Actively Recruiting
234
Regionalny Szpital Specjalistyczny im. dr. Władyslawa Biegańskiego ( Site 1316)
Grudziądz, Kuyavian-Pomeranian Voivodeship, Poland, 86-300
Actively Recruiting
235
Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu ( Site 1304)
Torun, Kuyavian-Pomeranian Voivodeship, Poland, 87-100
Active, Not Recruiting
236
Mazowiecki Szpital Wojewódzki w Siedlcach-Siedleckie Centrum Onkologii ( Site 1310)
Siedlce, Masovian Voivodeship, Poland, 08-110
Actively Recruiting
237
Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie-Oddzial Dzienny Chemioterapii ( Site 1303)
Koszalin, West Pomeranian Voivodeship, Poland, 75-581
Actively Recruiting
238
Zachodniopomorskie Centrum Onkologii ( Site 1311)
Szczecin, West Pomeranian Voivodeship, Poland, 71-730
Actively Recruiting
239
Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zakl-Klinika Onkologii Klinicznej, Dzial Ch ( Site 1318)
Kielce, Świętokrzyskie Voivodeship, Poland, 25-734
Actively Recruiting
240
Puerto Rico Medical Research Center LLC ( Site 1354)
Hato Rey, Puerto Rico, 00917
Active, Not Recruiting
241
Ad-Vance Medical Research-Research ( Site 1353)
Ponce, Puerto Rico, 00717
Actively Recruiting
242
Pan American Center for Oncology Trials - Ciudadela ( Site 1351)
San Juan, Puerto Rico, 00909
Active, Not Recruiting
243
National University Hospital ( Site 1376)
Singapore, Central Singapore, Singapore, 119074
Actively Recruiting
244
National Cancer Centre Singapore ( Site 1377)
Singapore, Central Singapore, Singapore, 168583
Actively Recruiting
245
Tan Tock Seng Hospital-Medical Oncology ( Site 1378)
Singapore, Central Singapore, Singapore, 308433
Actively Recruiting
246
Asan Medical Center-Oncology ( Site 1402)
Songpagu, Seoul, South Korea, 05505
Active, Not Recruiting
247
Seoul National University Hospital-Oncology ( Site 1401)
Seoul, South Korea, 03080
Actively Recruiting
248
Severance Hospital, Yonsei University Health System-Medical oncology ( Site 1404)
Seoul, South Korea, 03722
Actively Recruiting
249
Samsung Medical Center ( Site 1405)
Seoul, South Korea, 06351
Actively Recruiting
250
Hospital Jerez de la Frontera ( Site 1427)
Jerez de la Frontera, Cadiz, Spain, 11407
Actively Recruiting
251
Hospital Universitario Ramón y Cajal-Medical Oncology ( Site 1431)
Madrid, Madrid, Comunidad de, Spain, 28034
Actively Recruiting
252
Hospital Universitario 12 de Octubre-Medical Oncology ( Site 1433)
Madrid, Madrid, Comunidad de, Spain, 28041
Actively Recruiting
253
Complexo Hospitalario Universitario de Ourense ( Site 1426)
Ourense, Orense, Spain, 32005
Actively Recruiting
254
Fundación Instituto Valenciano de Oncología-Oncologico ( Site 1430)
Valencia, Valenciana, Comunitat, Spain, 46009
Actively Recruiting
255
Hospital Lucus Augusti-Oncology ( Site 1432)
Lugo, Spain, 27003
Actively Recruiting
256
HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO-Medical Oncology ( Site 1428)
Seville, Spain, 41013
Actively Recruiting
257
Karolinska Universitetssjukhuset Solna ( Site 1478)
Stockholm, Stockholm County, Sweden, 171 64
Active, Not Recruiting
258
Akademiska sjukhuset-Blod- och tumörsjukdomar ( Site 1477)
Uppsala, Uppsala County, Sweden, 751 85
Actively Recruiting
259
Sahlgrenska Universitetssjukhuset ( Site 1479)
Gothenburg, Västra Götaland County, Sweden, 413 45
Actively Recruiting
260
China Medical University Hospital-Department of Urology ( Site 1503)
Taichung, Taiwan, 40447
Actively Recruiting
261
National Cheng Kung University Hospital-Urology ( Site 1502)
Tainan, Taiwan, 704
Actively Recruiting
262
National Taiwan University Hospital-Urology ( Site 1506)
Taipei, Taiwan, 10002
Active, Not Recruiting
263
Taipei Veterans General Hospital ( Site 1505)
Taipei, Taiwan, 112
Actively Recruiting
264
Chang Gung Medical Foundation-Linkou Branch-Medical Oncology ( Site 1504)
Taoyuan, Taiwan, 333
Actively Recruiting
265
Chulalongkorn University ( Site 1530)
Bangkok, Bangkok, Thailand, 10330
Actively Recruiting
266
Faculty of Medicine Siriraj Hospital ( Site 1531)
Bangkok, Bangkok, Thailand, 10700
Actively Recruiting
267
Faculty of Medicine - Khon Kaen University ( Site 1526)
Muang, Changwat Khon Kaen, Thailand, 40002
Actively Recruiting
268
Songklanagarind hospital ( Site 1527)
Hat Yai, Changwat Songkhla, Thailand, 90110
Actively Recruiting
269
Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 1554)
Adana, Turkey (Türkiye), 01250
Actively Recruiting
270
Gulhane Egitim Arastirma Hastanesi ( Site 1558)
Ankara, Turkey (Türkiye), 06010
Actively Recruiting
271
Hacettepe Universite Hastaneleri-oncology hospital ( Site 1551)
Ankara, Turkey (Türkiye), 06230
Actively Recruiting
272
Memorial Ankara Hastanesi-Medical Oncology ( Site 1557)
Ankara, Turkey (Türkiye), 06520
Actively Recruiting
273
Ankara Bilkent Şehir Hastanesi-Medical Oncology ( Site 1552)
Ankara, Turkey (Türkiye), 06800
Actively Recruiting
274
Istanbul Universitesi Cerrahpasa-Medical Oncology ( Site 1555)
Istanbul, Turkey (Türkiye), 34668
Actively Recruiting
275
TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 1553)
Istanbul, Turkey (Türkiye), 34722
Actively Recruiting
276
Samsun Medical Park Hastanesi-medical oncology (1560)
Samsun, Turkey (Türkiye), 55200
Actively Recruiting
277
Addenbrooke's Hospital ( Site 1605)
Cambridge, Cambridgeshire, United Kingdom, CB2 2QQ
Actively Recruiting
278
The Royal Cornwall Hospital ( Site 1610)
Truro, England, United Kingdom, TR1 3LJ
Actively Recruiting
279
The Beatson West of Scotland Cancer Centre ( Site 1603)
Glasgow, Glasgow City, United Kingdom, G12 0YN
Actively Recruiting
280
Charing Cross Hospital-Oncology Research ( Site 1606)
London, Hammersmith and Fulham, United Kingdom, W6 8RF
Actively Recruiting
281
University College London Hospital ( Site 1612)
London, London, City of, United Kingdom, NW1 2PG
Active, Not Recruiting
282
The Christie NHS Foundation Trust ( Site 1608)
Manchester, United Kingdom, m20 4bx
Actively Recruiting
Research Team
T
Toll Free Number
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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