Actively Recruiting
A Multi-Disciplinary Approach to Opportunistic Salpingectomy for Preventing Ovarian Cancer in Women Undergoing Non-Gynecologic Surgery
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-01-23
266
Participants Needed
10
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying the interest of women aged 45 years and older in a preventive surgery called opportunistic salpingectomy to reduce the risk of ovarian cancer. The study involves showing participants an educational video and assessing their interest before and after watching it through questionnaires completed in the clinic. This study is sponsored by Memorial Sloan Kettering Cancer Center and focuses on women undergoing non-gynecologic abdominal or pelvic surgery who do not plan to have children in the future. Participants will first complete an educational module that includes assessments before and after watching the video. Those who proceed may then have an opportunistic salpingectomy, which is the removal of fallopian tubes, incorporated into their scheduled non-gynecologic abdominal or pelvic surgery. The study tracks the rate at which participants choose to undergo this procedure after the educational intervention, with follow-up lasting up to two years. During the study, participants will attend clinic visits to answer questionnaires related to the educational video. Researchers will monitor how many women opt for the salpingectomy procedure after viewing the module. Eligibility is assessed by surgeons based on medical history and surgery plans, and participants must provide informed consent. The study aims to evaluate interest and uptake of this preventive surgery, with ongoing follow-up and monitoring during the two-year period.
CONDITIONS
Brief Title
A Study of Opportunistic Salpingectomy to Prevent Ovarian Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 45 years or older
- Scheduled visit with a non-gynecologic surgeon
- Female or assigned female at birth
- At least one fallopian tube present
- No desire or plan to have children in the future
- Average risk for developing ovarian cancer (no known genetic risk factors)
- Planned non-gynecologic, intraabdominal, or pelvic surgery
- Approved and signed informed consent
- Suitable candidate as determined by gynecologic and primary surgeons based on surgical history and current health status
You will not qualify if you...
- Not fluent in English or Spanish (except for strong candidates who may proceed directly to Part 2)
- Known inherited ovarian cancer susceptibility
- Personal history of gynecologic cancer
- Carrier of hereditary breast or ovarian cancer variants (e.g., BRCA1, BRCA2, BRIP1, PALB2, RAD51C, RAD51D, MLH1, MSH2, MSH6, PMS2)
- Suspicious lesions on preoperative imaging of ovaries, fallopian tubes, or uterus
- Previous removal of both fallopian tubes or both ovaries and fallopian tubes
- Presence of tubal-implanted birth control devices like ESSURE at surgery time
- Current pregnancy
- Emergency procedure requiring completion within 24 hours where clinical consent occurs inpatient or life-threatening condition
- Surgeon anticipates opportunistic salpingectomy will add significant time (>30-40 minutes) to planned surgery
- Inability to access pelvis during surgery (e.g., patient position)
- History of pelvic fibrosis or significant adhesions
- Procedures performed with palliative intent only
AI-Screening
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Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Duration - Up to 2 years
Participants complete an education module with premodule and postmodule assessment questionnaires.
1 to 2 visits depending on assessment timing
Duration - Surgery day and immediate recovery
Participants undergo opportunistic salpingectomy incorporated into their scheduled non-gynecologic abdominopelvic surgery.
1 surgical visit (in-person)
Trial Site Locations
Total: 10 locations
1
Johns Hopkins University (Data Collection Only)
Baltimore, Maryland, United States, 21287
Actively Recruiting
2
Dana Farber Cancer Institute (Data Collection Only)
Boston, Massachusetts, United States, 02115
Not Yet Recruiting
3
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
4
Memorial Sloan Kettering Monmouth (Limited protocol activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
5
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center @ Suffolk-Commack (Limited protocol activities)
Commack, New York, United States, 11725
Actively Recruiting
7
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
Harrison, New York, United States, 10604
Actively Recruiting
8
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, United States, 10065
Actively Recruiting
9
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
Uniondale, New York, United States, 11553
Actively Recruiting
10
MD Anderson Cancer Center (Data Collection Only)
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
K
Kara Long Roche, MD
M
Martin Weiser, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SEQUENTIAL
Primary Purpose
PREVENTION
Number of Arms
1
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