Actively Recruiting
Study of Oral Atogepant Tablets to Assess Safety and Efficacy in Adult Participants With Migraine
Led by AbbVie · Updated on 2026-05-12
1300
Participants Needed
149
Research Sites
135 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A migraine attack is a moderate or severe headache that usually occurs on one side of the head and is often accompanied by throbbing, sensitivity to light, sensitivity to sound, nausea, or other symptoms. The main goal of the study is to see if atogepant is effective, safe, and well-tolerated in treating migraine attacks quickly. Atogepant is a medicine currently approved for the preventive treatment of migraine in adults and has been shown to be effective and well tolerated when taken daily to prevent migraine attacks. This study includes double-blind phase means that neither the participants nor the study doctors know who is given which study treatment (atogepant or placebo) followed by an open-label phase meaning that both participants and study doctors know which study treatment is given. All participants will receive atogepant during the open-label part of the study. This study will include 1300 participants aged 18-75 years with a history of migraine at approximately 160 sites across the world. All participants will receive both atogepant and placebo to treat qualifying migraines. At the start of the study, participants will be randomized to 1 of 4 dosing sequences to determine when they will receive atogepant and when they will receive placebo during the study. After treating 4 qualifying migraine attacks, participants will receive open-label atogepant for any additional migraine attacks they have until the end of the study (Week 24). There may be a bigger responsibility for participants in this study than there would be in participants receiving standard of care treatment. participants will attend regular visits during the study at a hospital or clinic, as well as telephone visits, and the effects of treatment will be checked by completion of questionnaires in an electronic diary, medical assessments, blood tests, and checking for side effects.
CONDITIONS
Official Title
Study of Oral Atogepant Tablets to Assess Safety and Efficacy in Adult Participants With Migraine
Who Can Participate
Eligibility Criteria
You may qualify if you...
- History of migraine (with or without aura) for at least 12 months before screening
- 2 to 8 moderate to severe migraine attacks per month in the 3 months before screening
- Migraine started before age 50
- Migraines last between 4 and 72 hours untreated or unsuccessfully treated
- Migraine episodes separated by at least 48 hours without headache pain
You will not qualify if you...
- Average of 15 or more headache days per month in the 6 months before screening or current chronic migraine diagnosis
- Required hospital or emergency room treatment for migraine attacks 3 or more times in the 6 months before screening
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 149 locations
1
Universitair Ziekenhuis Antwerpen /ID# 257582
Edegem, Antwerpen, Belgium, 2650
Active, Not Recruiting
2
Universitair Ziekenhuis Brussel /ID# 257584
Jette, Brussels Capital, Belgium, 1090
Actively Recruiting
3
Cabinet Prive Dr Sava /ID# 257581
Saint-Nicolas, Liege, Belgium, 4420
Actively Recruiting
4
Jessa Ziekenhuis /ID# 257578
Hasselt, Limburg, Belgium, 3500
Active, Not Recruiting
5
AZ Sint-Jan Brugge /ID# 257585
Bruges, West-Vlaanderen, Belgium, 8000
Active, Not Recruiting
6
AZ Groeninge /ID# 257586
Kortrijk, Belgium, 8500
Actively Recruiting
7
H.-Hartziekenhuis Lier /ID# 257577
Lier, Belgium, 2500
Actively Recruiting
8
CHR de la Citadelle /ID# 257587
Liège, Belgium, 4000
Actively Recruiting
9
The first affiliated hospital of bengbu medical college /ID# 258758
Bengbu, Anhui, China, 233004
Completed
10
Beijing Friendship Hospital /ID# 258830
Beijing, Beijing Municipality, China, 100032
Completed
11
Xuanwu Hospital Capital Medical University /ID# 258510
Beijing, Beijing Municipality, China, 100053
Completed
12
Peking University Third Hospital /ID# 259573
Beijing, Beijing Municipality, China, 100191
Completed
13
Chinese PLA General Hospital /ID# 257540
Beijing, Beijing Municipality, China, 100853
Completed
14
Peking University First Hospital /ID# 258672
Xicheng District, Beijing Municipality, China, 100034
Completed
15
Fujian Medical University Union Hospital /ID# 259575
Fuzhou, Fujian, China, 350001
Completed
16
The First Affiliated Hospital of Xiamen University /ID# 259576
Xiamen, Fujian, China, 361003
Completed
17
Lanzhou University Second Hospital /ID# 259667
Lanzhou, Gansu, China, 730030
Completed
18
Guangzhou First People's Hospital /ID# 258656
Guangzhou, Guangdong, China, 510180
Completed
19
The Second Affiliated Hospital of Guangzhou Medical University /ID# 258638
Guangzhou, Guangdong, China, 510260
Completed
20
The University Of Hong Kong - Shenzhen Hospital /ID# 258462
Shenzhen, Guangdong, China, 518053
Completed
21
The Affiliated Hospital of Guizhou Medical University /ID# 259536
Guiyang, Guizhou, China, 550004
Completed
22
Hainan General Hospital /ID# 259548
Haikou, Hainan, China, 570311
Completed
23
Hebei General Hospital /ID# 258583
Shijiazhuang, Hebei, China, 500051
Completed
24
Zhengzhou People's Hospital /ID# 258670
Zhengzhou, Henan, China, 450012
Completed
25
The Second Xiangya Hospital Of Central South University /ID# 260623
Changsha, Hunan, China, 410011
Completed
26
The Third Xiangya Hospital of Central South University /ID# 258787
Changsha, Hunan, China, 410013
Completed
27
Zhuzhou Central Hospital /ID# 260076
Zhuzhou, Hunan, China, 412007
Completed
28
The Second Affiliated Hospital of Nanjing Medical University /ID# 258648
Nanjing, Jiangsu, China, 210011
Completed
29
The Second Affiliated Hospital of Soochow University /ID# 259551
Suzhou, Jiangsu, China, 215004
Completed
30
The First Affiliated Hospital of Soochow University /ID# 258783
Suzhou, Jiangsu, China, 215031
Completed
31
Jiangxi Pingxiang Peoples Hospital /ID# 258652
Pingxiang, Jiangxi, China, 337055
Completed
32
The First Hospital of Jilin University /ID# 259585
Changchun, Jilin, China, 130021
Completed
33
The Second hospital of Jilin university /ID# 258556
Changchun, Jilin, China, 130022
Completed
34
General Hospital of Northern Theater Command /ID# 259556
Shenyang, Liaoning, China, 110016
Completed
35
Shaanxi Provincial PeopleS Hospital /ID# 259529
Xi'an, Shaanxi, China, 710054
Completed
36
Second Hospital of Shanxi Medical University /ID# 259669
Taiyuan, Shanxi, China, 030001
Completed
37
West China Hospital, Sichuan University /ID# 258664
Chengdu, Sichuan, China, 610041
Completed
38
Tianjin Medical University General Hospital /ID# 259513
Tianjin, Tianjin Municipality, China, 300052
Completed
39
Tianjin People's Hospital /ID# 258625
Tianjin, Tianjin Municipality, China, 300120
Completed
40
The Second Affiliated Hospital of Zhejiang University School of Medicine /ID# 258860
Hangzhou, Zhejiang, China, 310009
Completed
41
The First Affiliated Hospital of Wenzhou Medical University /ID# 258939
Wenzhou, Zhejiang, China, 325000
Completed
42
Baotou Central Hospital /ID# 258786
Baotou, China, 014040
Completed
43
The first people's Hospital Affiliated to Shanghai Jiaotong University /ID# 259554
Shanghai, China, 200080
Completed
44
CCR Ostrava, s.r.o. /ID# 257743
Ostrava, Ostrava-mesto, Czechia, 702 00
Actively Recruiting
45
Fakultni Nemocnice Ostrava /ID# 259023
Ostrava, Ostrava-mesto, Czechia, 708 52
Actively Recruiting
46
Praglandia /ID# 257667
Prague, Praha 5, Czechia, 150 00
Actively Recruiting
47
NeuroHK s.r.o. /ID# 257671
Hradec Králové, Czechia, 500 09
Actively Recruiting
48
Clintrial s.r.o. /ID# 257663
Prague, Czechia, 100 00
Actively Recruiting
49
DADO MEDICAL s.r.o. /ID# 257672
Prague, Czechia, 120 00
Actively Recruiting
50
Axon Clinical, s.r.o. /ID# 259024
Prague, Czechia, 140 00
Actively Recruiting
51
Fakultni Thomayerova nemocnice /ID# 259021
Prague, Czechia, 140 59
Actively Recruiting
52
FORBELI s.r.o. /ID# 259019
Prague, Czechia, 160 00
Actively Recruiting
53
INEP medical s.r.o. /ID# 257669
Prague, Czechia, 186 00
Actively Recruiting
54
Vestra Clinics s.r.o. /ID# 259022
Rychnov nad Kněžnou, Czechia, 516 01
Actively Recruiting
55
Neuropraxis Muenchen Sued /ID# 258077
Unterhaching, Bavaria, Germany, 82008
Actively Recruiting
56
Kopfschmerzzentrum - Frankfurt /ID# 258019
Frankfurt am Main, Hesse, Germany, 65929
Actively Recruiting
57
Studienzentrum Nord-West /ID# 258024
Westerstede, Lower Saxony, Germany, 26655
Completed
58
Universitaetsklinikum Duesseldorf /ID# 258078
Düsseldorf, North Rhine-Westphalia, Germany, 40225
Completed
59
Ambenet Hausarztpraxis /ID# 258075
Leipzig, Saxony, Germany, 04107
Actively Recruiting
60
Schmerzklinik Kiel /ID# 258005
Kiel, Schleswig-Holstein, Germany, 24149
Completed
61
Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 258076
Berlin, Germany, 10117
Actively Recruiting
62
Universitaetsklinikum Essen /ID# 258023
Essen, Germany, 45147
Completed
63
Vitos Orthopaedische Klinik Kassel gemeinnuetzige GmbH /ID# 258008
Kassel, Germany, 34131
Completed
64
Velocity Clinical Research /ID# 258020
Wiesbaden, Germany, 65189
Actively Recruiting
65
Jávorszky Ödön Kórház /ID# 258969
Vác, Pest County, Hungary, 2600
Completed
66
Cortex Study Center /ID# 259032
Budapest, Hungary, 1026
Actively Recruiting
67
Semmelweis Egyetem /ID# 258546
Budapest, Hungary, 1085
Actively Recruiting
68
Semmelweis Egyetem /ID# 258800
Budapest, Hungary, 1085
Completed
69
UNO Medical Trials /ID# 259186
Budapest, Hungary, 1135
Completed
70
S-Medicon Kft /ID# 258547
Budapest, Hungary, 1138
Actively Recruiting
71
Istituto Neurologico Mediterraneo Neuromed /ID# 258593
Pozzilli, Isernia, Italy, 86077
Actively Recruiting
72
ASL 1 Abruzzo - Ospedale SS. Filippo and Nicola /ID# 258590
Avezzano, L Aquila, Italy, 67051
Actively Recruiting
73
IRCCS Ospedale San Raffaele /ID# 258592
Milan, Milano, Italy, 20132
Actively Recruiting
74
Istituto Auxologico Italiano - Irccs /ID# 258623
Milan, Milano, Italy, 20145
Actively Recruiting
75
A.O.U. CITTA' DELLA SALUTE E DELLA SCIENZA DI TORINO - Ospedale Molinette /ID# 258591
Turin, Piedmont, Italy, 10126
Actively Recruiting
76
Univ. of Bologna-IRCCS-Istituto delle Scienze Neurologiche /ID# 261089
Bologna, Italy, 40126
Actively Recruiting
77
ASST degli Spedali Civili di Brescia /ID# 258594
Brescia, Italy, 25123
Actively Recruiting
78
ICOT Istituto Marco Pasquali /ID# 258621
Latina, Italy, 04100
Active, Not Recruiting
79
Fondazione Mondino Istituto Neurologico Nazionale a Carattere Scientifico IRCCS /ID# 258589
Pavia, Italy, 27100
Active, Not Recruiting
80
Fondazione Policlinico Universitario Campus Bio-Medico /ID# 258588
Roma, Italy, 00128
Actively Recruiting
81
Ospedale San Paolo - ASL2 /ID# 258622
Savona, Italy, 17100
Active, Not Recruiting
82
Tokyo Dental College Ichikawa General Hospital /ID# 259570
Ichikawa-shi, Chiba, Japan, 272-0824
Completed
83
Ikeda Neurosurgical Clinic /ID# 259085
Kasuga-shi, Fukuoka, Japan, 816-0824
Actively Recruiting
84
Higashi Sapporo Neurology And Neurosurgery Clinic /ID# 262708
Sapporo, Hokkaido, Japan, 003-0003
Completed
85
Umenotsuji Clinic /ID# 258717
Kochi, Kochi, Japan, 780-8011
Completed
86
Sendai Headache and Neurology Clinic Medical Corporation /ID# 258862
Sendai, Miyagi, Japan, 982-0014
Actively Recruiting
87
Tominaga Clinic - Osaka /ID# 258553
Osaka, Osaka, Japan, 556-0015
Actively Recruiting
88
Usuda Clinic Of Internal Medicine /ID# 260422
Setagaya-ku, Tokyo, Japan, 156-0043
Active, Not Recruiting
89
Tokyo Headache Clinic /ID# 258534
Shibuya-ku, Tokyo, Japan, 151-0051
Actively Recruiting
90
Nagaseki Headache Clinic /ID# 259214
Kai, Yamanashi, Japan, 400-0124
Actively Recruiting
91
DOI Internal Medicine-Neurology Clinic /ID# 259009
Hiroshima, Japan, 730-0031
Actively Recruiting
92
Tatsuoka Neurology Clinic /ID# 258771
Kyoto, Japan, 600-8811
Completed
93
Solumed Centrum Medyczne /ID# 258288
Poznan, Greater Poland Voivodeship, Poland, 60-529
Actively Recruiting
94
Clinical Research Center Medic-R /ID# 258268
Poznan, Greater Poland Voivodeship, Poland, 60-848
Actively Recruiting
95
Vitamed Galaj i Cichomski Sp.j. /ID# 258278
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-079
Actively Recruiting
96
Athleticomed Sp. z o.o /ID# 258253
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-752
Actively Recruiting
97
Linden Sp. z o.o. sp.k. /ID# 258283
Krakow, Lesser Poland Voivodeship, Poland, 30-721
Actively Recruiting
98
Instytut Zdrowia Dr Boczarska Jedynak /ID# 258248
Oświęcim, Lesser Poland Voivodeship, Poland, 32-600
Actively Recruiting
99
Indywidualna Praktyka Lekarska dr hab. med. Anna Szczepanska-Szerej /ID# 258281
Lublin, Lublin Voivodeship, Poland, 20-582
Actively Recruiting
100
Centrum Badan Klinicznych PI-House sp. z o.o. /ID# 258250
Gdansk, Pomeranian Voivodeship, Poland, 80-546
Actively Recruiting
101
Silmedic Sp. z o.o. /ID# 258249
Katowice, Silesian Voivodeship, Poland, 40-282
Actively Recruiting
102
MIGRE Polskie Centrum Leczenia Migreny Anna Gryglas-Dworak /ID# 258287
Wroclaw, Poland, 52-210
Actively Recruiting
103
Unidade Local de Saude do Alto Ave, EPE /ID# 257986
Guimarães, Braga District, Portugal, 4835-044
Actively Recruiting
104
Unidade Local de Saude de Almada-Seixal, EPE /ID# 257987
Almada, Setúbal District, Portugal, 2805-267
Actively Recruiting
105
Hospital da Luz Lisboa /ID# 257983
Lisbon, Portugal, 1500-650
Actively Recruiting
106
Unidade Local de Saude de Santa Maria, EPE /ID# 257989
Lisbon, Portugal, 1649-035
Actively Recruiting
107
Unidade Local de Saude de Santo Antonio, E.P.E. /ID# 258140
Porto, Portugal, 4099-003
Actively Recruiting
108
Unidade Local de Saude da Arrabida, EPE /ID# 258139
Setúbal, Portugal, 2910-446
Actively Recruiting
109
Univerzitna nemocnica - Nemocnica svateho Michala a.s. /ID# 257909
Bratislava, Bratislava Region, Slovakia, 811 08
Actively Recruiting
110
Poliklinika Bezrucova (Cliniq s.r.o.) /ID# 257961
Bratislava, Bratislava Region, Slovakia, 811 09
Actively Recruiting
111
University Hospital Bratislava - Hospital ak. L. Derera /ID# 257947
Bratislava, Bratislava Region, Slovakia, 831 01
Actively Recruiting
112
Neurologicka a algeziologicka ambulancia, SANERA /ID# 259176
Prešov, Presov, Slovakia, 080 01
Actively Recruiting
113
MUDr. Beata Dupejova neurologicka ambulancia s.r.o. /ID# 257901
Banská Bystrica, Slovakia, 974 04
Actively Recruiting
114
Liptovska nemocnica s poliklinikou MUDr. Ivana Stodolu Liptovsky Mikulas /ID# 258315
Liptovský Mikuláš, Žilina Region, Slovakia, 031 23
Completed
115
Hallym University Dongtan Sacred Heart Hospital /ID# 257999
Hwaseong, Gyeonggido, South Korea, 18450
Actively Recruiting
116
Chonnam National University Hospital /ID# 259154
Gwangju, Jeonranamdo, South Korea, 61469
Actively Recruiting
117
Nowon Eulji Medical Center, Eulji University /ID# 258000
Seoul, Seoul Teugbyeolsi, South Korea, 01830
Actively Recruiting
118
Seoul National University Hospital /ID# 258002
Seoul, Seoul Teugbyeolsi, South Korea, 03080
Actively Recruiting
119
Kangbuk Samsung Hospital /ID# 258001
Seoul, Seoul Teugbyeolsi, South Korea, 03181
Actively Recruiting
120
Yonsei University Health System Severance Hospital /ID# 257998
Seoul, South Korea, 03722
Actively Recruiting
121
Hospital Universitario Marques de Valdecilla /ID# 257658
Santander, Cantabria, Spain, 39008
Actively Recruiting
122
Clinica Universidad de Navarra - Pamplona /ID# 257656
Pamplona, Navarre, Spain, 31008
Completed
123
Hospital Universitario Vall de Hebron /ID# 257652
Barcelona, Spain, 08035
Actively Recruiting
124
Hospital Universitario La Paz /ID# 257654
Madrid, Spain, 28046
Actively Recruiting
125
Hospital Universitario Virgen del Rocio /ID# 257657
Seville, Spain, 41013
Actively Recruiting
126
Hospital Universitario y Politecnico La Fe /ID# 257655
Valencia, Spain, 46026
Actively Recruiting
127
Hospital Clinico Universitario de Valladolid /ID# 257653
Valladolid, Spain, 47003
Completed
128
Hospital Clinico Universitario Lozano Blesa /ID# 257661
Zaragoza, Spain, 50009
Completed
129
Skaneuro Privatmottagning /ID# 258833
Lund, Skåne County, Sweden, 227 33
Actively Recruiting
130
Karolinska Universitetssjukhuset - Huddinge /ID# 258837
Huddinge, Stockholm County, Sweden, 141 57
Completed
131
Neurology Clinic /ID# 258835
Stockholm, Stockholm County, Sweden, 114 33
Completed
132
Optimuskliniken /ID# 258834
Upplands Vasby, Stockholm County, Sweden, 194 61
Completed
133
CTC EbbePark Linkoping /ID# 261170
Linköping, Sweden, 582 13
Actively Recruiting
134
Kuang-Tien General Hospital /ID# 258063
Taichung, Taichung, Taiwan, 433
Completed
135
Taipei Veterans General Hospital /ID# 258062
Taipei City, Taipei, Taiwan, 11217
Actively Recruiting
136
China Medical University Hospital /ID# 258417
Taichung, Taiwan, 40447
Actively Recruiting
137
Tri-Service General Hospital /ID# 258064
Taipei, Taiwan, 11490
Actively Recruiting
138
Linkou Chang Gung Memorial Hospital /ID# 259171
Taoyuan City, Taiwan, 333
Actively Recruiting
139
St Pancras Clinical Research /ID# 277704
Chester, Cheshire, United Kingdom, CH2 1HX
Actively Recruiting
140
North Coast Medical Ltd - Newquay Health Centre /ID# 260019
Newquay, Cornwall, United Kingdom, TR7 1RU
Active, Not Recruiting
141
Ashgate Medical Practice /ID# 258923
Chesterfield, Derbyshire, United Kingdom, S40 4AA
Actively Recruiting
142
The Adam Practice /ID# 258190
Poole, Dorset, United Kingdom, BH15 4JQ
Actively Recruiting
143
Queen Elizabeth University Hospital - NHS Greater Glasgow and Clyde /ID# 259384
Glasgow, Lanarkshire, United Kingdom, G51 4TF
Completed
144
Re:Cognition Health Birmingham /ID# 258186
Birmingham, United Kingdom, B16 8LT
Actively Recruiting
145
Re:Cognition Health Bristol /ID# 258187
Bristol, United Kingdom, BS32 4SY
Actively Recruiting
146
Re:Cognition Health - Guildford /ID# 258188
Guildford, United Kingdom, GU2 7YD
Completed
147
St Pancras Clinical Research /ID# 258183
London, United Kingdom, EC2Y 8EA
Actively Recruiting
148
The University of Nottingham Health Service /ID# 259380
Nottingham, United Kingdom, NG7 2QW
Actively Recruiting
149
Primary Care Sheffield /ID# 259448
Sheffield, United Kingdom, S9 4EU
Active, Not Recruiting
Research Team
A
ABBVIE CALL CENTER
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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