Oral Fluid Testing to Assess Cannabis Non-Use in Remote Clinical Trials

What this Trial Is About

Researchers are evaluating oral fluid testing to measure cannabis use days remotely among young adults aged 18 to 30 years who use cannabis at least once a week. The study involves 200 individuals from the community who have used cannabis recently and aims to assess how well saliva tests reflect recent cannabis use compared to urine tests and self-reports. Participants will complete a series of oral fluid (saliva) and urine tests along with interviews about their cannabis use over about three to four weeks. They will have three virtual study visits: the first for consent and baseline surveys, the second for urine testing and interviews, and the third for final testing and surveys. Between visits, participants will perform six days of at-home videorecorded oral fluid testing. During the study, participants will provide self-reports of cannabis use and complete various biological tests to compare results. Researchers will monitor adherence to the testing protocol, the accuracy of test results, and acceptability of oral fluid testing. The main outcomes include the duration and quality of oral fluid testing over six days and during the final visit. Total participation lasts roughly three to four weeks with remote visits and home testing.

Study of Oral Fluid Testing Approach