Actively Recruiting
Study of Oral Upadacitinib to Assess Change in Disease Activity in Adult Participants With Ulcerative Colitis
Led by AbbVie · Updated on 2026-05-13
400
Participants Needed
94
Research Sites
249 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine).This study will assess how effective upadacitinib is in treating UC. Upadacitinib (RINVOQ) is an approved drug for treating UC. Approximately 400 adult participants who are prescribed Upadacitinib by their physician in accordance with local label will be enrolled in Germany, Austria and Switzerland. Upadacitinib will be administered in accordance with the terms of the local marketing authorization, and treatment of participants will be determined solely by the investigator. Participants in the study will be followed for up to 2 years. There will be no additional burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic and only data which are routinely collected during a regular visit will be utilized for this study.
CONDITIONS
Official Title
Study of Oral Upadacitinib to Assess Change in Disease Activity in Adult Participants With Ulcerative Colitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants with an endoscopically confirmed diagnosis of active moderate to severe Ulcerative colitis (UC).
- Participants initiating Upadacitinib (UPA) at the investigator's discretion as part of their routine clinical care; the decision to administer UPA must be made prior to and independent of documentation for the study and according to the approved local label.
- Participants able to understand and communicate with the investigator and comply with the requirements of the study.
- Participants willing to continue with study documentation after cessation of UPA.
You will not qualify if you...
- Participants with any contraindication to Upadacitinib (UPA).
- Participants previously exposed to a Janus kinase (JAK) inhibitor.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 94 locations
1
Krankenhaus der Barmherzigen Brueder Wien /ID# 251867
Vienna, State of Vienna, Austria, 1020
Active, Not Recruiting
2
Kepler Universitaetsklinikum GmbH /ID# 251868
Linz, Upper Austria, Austria, 4020
Active, Not Recruiting
3
Krankenhaus der Barmherzigen Brueder Salzburg /ID# 251869
Salzburg, Austria, 5010
Active, Not Recruiting
4
Universitaetsklinik Heidelberg /ID# 249922
Heidelberg, Baden-Wurttemberg, Germany, 69120
Active, Not Recruiting
5
Praxis fuer Gastroenterologie /ID# 249917
Heidelberg, Baden-Wurttemberg, Germany, 69121
Active, Not Recruiting
6
Rems-Murr-Klinikum Winnenden /ID# 278791
Winnenden, Baden-Wurttemberg, Germany, 71364
Completed
7
Klinikum Augsburg /ID# 249979
Augsburg, Bavaria, Germany, 86156
Actively Recruiting
8
Medizinisches Versorgunszentrum Dachau /ID# 249945
Dachau, Bavaria, Germany, 85221
Active, Not Recruiting
9
TUM Klinikum rechts der Isar /ID# 262176
Munich, Bavaria, Germany, 81675
Active, Not Recruiting
10
Dr.med. Johannes Behrendt Facharzt für Innere Medizin und Gastroenterologie /ID# 260516
Brandenburg an der Havel, Brandenburg, Germany, 14776
Actively Recruiting
11
Praxis Dr. Grümmer /ID# 249925
Potsdam, Brandenburg, Germany, 14471
Completed
12
Private Practice - Dr. Kempelmann /ID# 249935
Tostedt, Free and Hanseatic City of Hamburg, Germany, 21255
Active, Not Recruiting
13
Klinikum Darmstadt /ID# 267685
Darmstadt, Hesse, Germany, 64283
Actively Recruiting
14
Praxis Dres. Hurst/Simonis /ID# 255421
Darmstadt, Hesse, Germany, 64293
Actively Recruiting
15
Interdisziplinaeres Crohn Colitis Zentrum /ID# 252622
Frankfurt am Main, Hesse, Germany, 60318
Actively Recruiting
16
Bethanien-Krankenhaus /ID# 260865
Frankfurt am Main, Hesse, Germany, 60389
Active, Not Recruiting
17
Gastroenterologie Opernstrasse Private Practice - Dr. Falk & Krause & Kuhn /ID# 251822
Kassel, Hesse, Germany, 34117
Actively Recruiting
18
Mueller/Mueller-Ziehm, Hanover /ID# 252617
Hanover, Lower Saxony, Germany, 30449
Active, Not Recruiting
19
Medizinische Hochschule Hannover /ID# 254980
Hanover, Lower Saxony, Germany, 30625
Active, Not Recruiting
20
Klinikum Lueneburg /ID# 249948
Lüneburg, Lower Saxony, Germany, 21339
Active, Not Recruiting
21
Verein für Wissenschaft und Forschung /ID# 249928
Oldenburg, Lower Saxony, Germany, 26123
Active, Not Recruiting
22
Private Practice - Dr. Mechthild Kemper & Dr. Markus Dreck /ID# 249916
Coesfeld, North Rhine-Westphalia, Germany, 48653
Actively Recruiting
23
Evangelisches Krankenhaus Kalk /ID# 249987
Cologne, North Rhine-Westphalia, Germany, 51103
Actively Recruiting
24
Gastroenterologische Gemeinschaftspraxis Herne /ID# 249990
Herne, North Rhine-Westphalia, Germany, 44623
Active, Not Recruiting
25
Gastroenterologische Gemeinschaftspraxis Minden /ID# 249914
Minden, North Rhine-Westphalia, Germany, 32423
Active, Not Recruiting
26
Dres. Mallach/Spelter /ID# 270912
Wuppertal, North Rhine-Westphalia, Germany, 42103
Actively Recruiting
27
Benner & Dommermuth /ID# 249896
Koblenz, Rhineland-Palatinate, Germany, 56068
Active, Not Recruiting
28
St. Marien- und St. Annastiftskrankenhaus /ID# 273172
Ludwigshafen am Rhein, Rhineland-Palatinate, Germany, 67067
Actively Recruiting
29
Klinikum Worms gGmbH /ID# 269804
Worms, Rhineland-Palatinate, Germany, 67550
Actively Recruiting
30
Gemeinschaftspraxis Drs. Denger und Pfitzner /ID# 249974
Friedrichsthal, Saarland, Germany, 66299
Active, Not Recruiting
31
Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 249971
Saarbrücken, Saarland, Germany, 66111
Actively Recruiting
32
Klinikum Chemnitz - Flemmingstraße /ID# 259156
Chemnitz, Saxony, Germany, 09116
Actively Recruiting
33
Universitaetsklinikum Carl Gustav Carus Dresden /ID# 249989
Dresden, Saxony, Germany, 01307
Actively Recruiting
34
Private Practice - Dr. Johannes Janschek /ID# 255092
Dresden, Saxony, Germany, 01309
Actively Recruiting
35
Universitaetsklinikum Leipzig /ID# 262612
Leipzig, Saxony, Germany, 04103
Actively Recruiting
36
Gesellschaft für klinische Studien /ID# 254081
Leipzig, Saxony, Germany, 04105
Actively Recruiting
37
Praxisgemeinschaft Jerichow Schulze /ID# 262931
Jerichow, Saxony-Anhalt, Germany, 39319
Active, Not Recruiting
38
Gemeinschaftspraxis im Medicum /ID# 249930
Altenholz, Schleswig-Holstein, Germany, 24161
Active, Not Recruiting
39
Praxis S. Tetzlaff /ID# 253770
Buedelsdorf, Schleswig-Holstein, Germany, 24782
Active, Not Recruiting
40
Thormann and Bethge /ID# 249897
Kiel, Schleswig-Holstein, Germany, 24105
Active, Not Recruiting
41
Gastroenterologisch - Hepatologisches MVZ Kiel GmbH /ID# 252623
Kiel, Schleswig-Holstein, Germany, 24146
Actively Recruiting
42
Universitaetsklinikum Schleswig-Holstein Campus Luebeck /ID# 249984
Lübeck, Schleswig-Holstein, Germany, 23538
Completed
43
Praxis fuer Gastroenterologie /ID# 249907
Lübeck, Schleswig-Holstein, Germany, 23560
Actively Recruiting
44
Friedrich-Ebert-Krankenhaus GmbH /ID# 249973
Neumünster, Schleswig-Holstein, Germany, 24534
Actively Recruiting
45
Gemeinschaftspraxis Dr. med. Maik Weisflog Dr. med. Katrin Ende /ID# 249918
Erfurt, Thuringia, Germany, 99084
Active, Not Recruiting
46
Universitaetsklinikum Jena /ID# 253768
Jena, Thuringia, Germany, 07747
Active, Not Recruiting
47
Universitaetsklinikum Jena /ID# 254371
Jena, Thuringia, Germany, 07747
Actively Recruiting
48
Praxis Dr. Schiffelholz /ID# 252621
Augsburg, Germany, 86150
Actively Recruiting
49
MVZ Gastro Friedrichshain /ID# 249924
Berlin, Germany, 10249
Active, Not Recruiting
50
Praxis Dr. Berndt /ID# 252067
Berlin, Germany, 10409
Actively Recruiting
51
Dres. Schick/Wesenberg /ID# 249977
Berlin, Germany, 10437
Actively Recruiting
52
MVZ fuer Gastroenterlogie am Bayerischen Platz /ID# 249981
Berlin, Germany, 10825
Active, Not Recruiting
53
Zweite Gemeinnuutzige Krankenhaus GmbH DRK Kliniken Berlin Kopenick /ID# 262849
Berlin, Germany, 12559
Active, Not Recruiting
54
Praxis S. Grüngreiff /ID# 249927
Berlin, Germany, 12683
Actively Recruiting
55
Praxis Dr. Soellenboehmer /ID# 249985
Berlin, Germany, 14052
Actively Recruiting
56
Praxis Dr. Spitz /ID# 252616
Berlin, Germany, 14163
Active, Not Recruiting
57
Krankenhaus Waldfriede /ID# 249900
Berlin-Zehlendorf, Germany, 14163
Actively Recruiting
58
Internist. Facharztp. Dr. Palmai /ID# 251821
Bitterfeld-Wolfen, Germany, 06749
Active, Not Recruiting
59
Alb-Donau Klinikum Blaubeuren, ADK GmbH für Gesundheit und Soziales /ID# 249923
Blaubeuren Abbey, Germany, 89143
Active, Not Recruiting
60
Frach/Hohaus, Dresden, DE /ID# 254979
Dresden, Germany, 01067
Actively Recruiting
61
Dres. Krause/Schiffer /ID# 251727
Frechen, Germany, 50226
Active, Not Recruiting
62
Dres. Bauer/Doerflinger /ID# 251568
Freiburg im Breisgau, Germany, 79102
Active, Not Recruiting
63
Internisten in Geldern /ID# 252068
Guelders, Germany, 47608
Active, Not Recruiting
64
Universitaetsklinikum Halle (Saale) /ID# 254083
Halle, Germany, 06120
Actively Recruiting
65
Private Practice - Dr. Matthias Eichler /ID# 249933
Hamburg, Germany, 22041
Active, Not Recruiting
66
Tappe/Miks/Delker, Hamm, DE /ID# 251729
Hamm, Germany, 59065
Actively Recruiting
67
Internistische Praxisgemeinschaft Hanau GbR /ID# 254079
Hanau, Germany, 63452
Actively Recruiting
68
Gastroenterologische Gemeinschaftspraxis /ID# 263633
Heilbronn, Germany, 74072
Actively Recruiting
69
Städtisches Kh. Heinsberg GmbH /ID# 252624
Heinsberg, Germany, 52525
Active, Not Recruiting
70
Praxis Dres. Preiss/Engelke /ID# 249919
Herne, Germany, 44649
Active, Not Recruiting
71
Praxis Dr. Schwarz /ID# 251819
Hettstedt, Germany, 06333
Active, Not Recruiting
72
MVZ Dres. Al-Kadi & Partner /ID# 249929
Iserlohn, Germany, 58644
Active, Not Recruiting
73
Praxis Dr. Weber /ID# 256099
Jena, Germany, 07743
Actively Recruiting
74
Gastroenterologe am Ettlinger Tor /ID# 249982
Karlsruhe, Germany, 76133
Actively Recruiting
75
MVZ Doceins West GmbH /ID# 249915
Koblenz, Germany, 56068
Actively Recruiting
76
MVZ Gastroenterologie Leverkusen /ID# 260512
Leverkusen, Germany, 51375
Active, Not Recruiting
77
Gastropraxis Magdeburg /ID# 249988
Magdeburg, Germany, 39104
Active, Not Recruiting
78
Praxis Dr. Burlefinger /ID# 259159
Munich, Germany, 80336
Actively Recruiting
79
Prof-med-stud.de /ID# 255419
Munich, Germany, 80935
Actively Recruiting
80
Medizinisches Versorgungszentrum Portal 10 /ID# 249947
Münster, Germany, 48155
Actively Recruiting
81
Gastro Campus Research GbR /ID# 249983
Münster, Germany, 48159
Actively Recruiting
82
Praxis Dres Brendel /ID# 254078
Nuremberg, Germany, 90449
Actively Recruiting
83
Medius Klinik Nürtingen /ID# 255420
Nürtingen, Germany, 72622
Completed
84
Pc Docs /Id# 249921
Pirmasens, Germany, 66953
Active, Not Recruiting
85
Elisabeth Klinikum GmbH /ID# 252264
Schmalkalden, Germany, 98574
Actively Recruiting
86
Praxis fuer Gastroenterologie /ID# 252615
Schwerin, Germany, 19057
Actively Recruiting
87
Dres. Rehbehn/Skusa /ID# 252618
Solingen, Germany, 42651
Active, Not Recruiting
88
bauchraum Gastroenterologisches Zentrum Dres. F. Kuehl, C. Hartmann, T. Klag BAG /ID# 251567
Stuttgart, Germany, 70435
Actively Recruiting
89
Dr. Schirin-Sokhan /ID# 259158
Würselen, Germany, 52146
Active, Not Recruiting
90
Zentrum fur Gastroenterologie und Hepatologie /ID# 260967
Zurich, Canton of Zurich, Switzerland, 8048
Actively Recruiting
91
University Hospital Zurich /ID# 260966
Zurich, Canton of Zurich, Switzerland, 8091
Active, Not Recruiting
92
EOC Ospedale Regionale Lugano /ID# 277165
Lugano, Canton Ticino, Switzerland, 6900
Active, Not Recruiting
93
Inselspital, Universitaetsspital Bern /ID# 260968
Bern, Switzerland, 3010
Active, Not Recruiting
94
Berner IBD Study Group /ID# 262315
Bern, Switzerland, 3012
Active, Not Recruiting
Research Team
M
Medical Information Germany
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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