Actively Recruiting
A Study of Orforglipron in Female Participants With Stress Urinary Incontinence Who Have Obesity or Overweight
Led by Eli Lilly and Company · Updated on 2026-05-14
1000
Participants Needed
136
Research Sites
126 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The GZPS master protocol will support two independent studies, J2A-MC-GZS1 and J2A-MC-GZS2. Each study will see how well and safely orforglipron works in adult female participants with stress urinary incontinence (SUI) who have obesity or overweight. SUI is leaking urine during movement or activity such as coughing or exercising. Participation in the study will last about 58 weeks from screening to safety follow-up.
CONDITIONS
Official Title
A Study of Orforglipron in Female Participants With Stress Urinary Incontinence Who Have Obesity or Overweight
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a body mass index (BMI) of 27 kilograms per square meter (kg/m2) or higher at screening
- Have a diagnosis of stress urinary incontinence
You will not qualify if you...
- Have had urinary incontinence surgery
- Have recently received onabotulinumtoxin A (Botox) bladder injections or currently taking medications for urinary incontinence
- Have given birth within one year of screening
- Have had a change in body weight of more than 11 pounds within 90 days prior to screening
- Have used any anti-obesity medication or alternative weight loss remedies within 180 days prior to screening
- Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
- Have had a cardiovascular health condition within 90 days prior to screening
- Are pregnant, intending to be pregnant, breastfeeding, or intending to breastfeed for the duration of the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 136 locations
1
University of Alabama -The Kirklin Clinic
Birmingham, Alabama, United States, 35233
Actively Recruiting
2
AMR Clinical
Mobile, Alabama, United States, 36608
Actively Recruiting
3
Urologic Surgeons of Arizona
Mesa, Arizona, United States, 85206
Actively Recruiting
4
Matrix Clinical Research
Los Angeles, California, United States, 90057
Actively Recruiting
5
Alarcon Urology Center
Montebello, California, United States, 90640
Actively Recruiting
6
Prestige Medical Group
Tustin, California, United States, 92780
Actively Recruiting
7
Colorado Clinical Research
Lakewood, Colorado, United States, 80228
Actively Recruiting
8
AMR Clinical
Fort Myers, Florida, United States, 33912
Actively Recruiting
9
Altus Research
Lake Worth, Florida, United States, 33461
Actively Recruiting
10
New Age Medical Research Corporation
Miami, Florida, United States, 33186
Actively Recruiting
11
Emerald Coast OBGYN Clinical Research
Panama City, Florida, United States, 32405
Actively Recruiting
12
Teak Research Consults
Lawrenceville, Georgia, United States, 30043
Actively Recruiting
13
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
Troy, Michigan, United States, 48098
Actively Recruiting
14
OB/GYN Associates of Erie
Erie, Pennsylvania, United States, 16507
Actively Recruiting
15
Clinical Research of Philadelphia
Philadelphia, Pennsylvania, United States, 19114
Actively Recruiting
16
Next Level Urgent Care
Houston, Texas, United States, 77057
Actively Recruiting
17
Innovative Medical Research of Texas
Houston, Texas, United States, 77065
Actively Recruiting
18
Health Research of Hampton Roads, Inc.
Newport News, Virginia, United States, 23606
Actively Recruiting
19
Urology of Virginia
Virginia Beach, Virginia, United States, 23462
Actively Recruiting
20
Northwest Clinical Research Center
Bellevue, Washington, United States, 98007
Actively Recruiting
21
Seattle Clinical Research Center
Seattle, Washington, United States, 98104
Actively Recruiting
22
OCT Research ULC
Kelowna, Canada, V1Y 1Z9
Actively Recruiting
23
Kelowna Health and Memory Centre
Kelowna, Canada, V1Y 5A8
Actively Recruiting
24
Alpha Recherche Clinique - Lévis
Lévis, Canada, G6V 0C9
Actively Recruiting
25
The Fe/Male Health Centre
Oakville, Canada, L6H 3P1
Actively Recruiting
26
Alpha Recherche Clinique
Québec, Canada, G2J 0C4
Actively Recruiting
27
ALPHA Recherche Clinique
Québec, Canada, G3K 2P8
Actively Recruiting
28
CaRe Clinic
Red Deer, Canada, T4P 1K4
Actively Recruiting
29
Sunnybrook Research Institute
Toronto, Canada, M4N 3M5
Actively Recruiting
30
Peking University First Hospital
Beijing, China, 100032
Actively Recruiting
31
Peking University People's Hospital
Beijing, China, 100034
Actively Recruiting
32
Xuanwu Hospital Capital Medical University
Beijing, China, 100053
Actively Recruiting
33
Peking University Third Hospital
Beijing, China, 100091
Actively Recruiting
34
Chengdu Women and Children Center Hospital
Chengdu, China, 610091
Actively Recruiting
35
2nd Affiliated Hospital Chongqing Medical University
Chongqing, China, 400010
Actively Recruiting
36
Zhujiang Hospital
Guangzhou, China, 510280
Actively Recruiting
37
The First Affiliated Hospital of Jinan University
Guangzhou, China, 510630
Actively Recruiting
38
Zhejiang Provincial People's Hospital
Hangzhou, China, 310014
Actively Recruiting
39
Second Affiliated hospital of Anhui Medical University
Hefei, China, 230000
Actively Recruiting
40
Gansu Provincial Hospital
Lanzhou, China, 730000
Actively Recruiting
41
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
Nanjing, China, 210000
Actively Recruiting
42
Ningbo First Hospital
Ningbo, China, 315010
Actively Recruiting
43
Obstetrics & Gynecology Hospital of Fudan University
Shanghai, China, 200011; 200090
Actively Recruiting
44
Peking University Shenzhen Hospital
Shenzhen, China, 518036
Actively Recruiting
45
The Second Affiliated Hospital of Soochow University
Suzhou, China, 215004
Actively Recruiting
46
Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology
Wuhan, China, 430030
Actively Recruiting
47
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, China, 710061
Actively Recruiting
48
The First Affiliated hospital of Xiamen University
Xiamen, China, 361003
Actively Recruiting
49
General Hospital of Ningxia Medical University
Yinchuan, China, 750004
Actively Recruiting
50
Afimed - Urologicka ambulance
Benešov, Czechia, 256 01
Actively Recruiting
51
Gynekologie Šottner
Brno, Czechia, 603 00
Actively Recruiting
52
Centrum Panevniho Dna
Karlovy Vary, Czechia, 360 17
Actively Recruiting
53
Kestr-gyn
Náchod, Czechia, 547 01
Actively Recruiting
54
G-CENTRUM Olomouc
Olomouc, Czechia, 772 00
Actively Recruiting
55
NEUMED gynekologická ambulance
Olomouc, Czechia, 779 00
Actively Recruiting
56
GYNORD plus
Ostrava, Czechia, 709 00
Actively Recruiting
57
Gyncare
Pilsen, Czechia, 301 00
Actively Recruiting
58
Nestátní zdravotnické zařízení GONA
Prague, Czechia, 110 00
Actively Recruiting
59
Devasya Superspeciality Kidney & Multispeciality Hospitals
Ahmedabad, India, 380013
Not Yet Recruiting
60
Apollo Hospitals Ahmedabad
Ahmedabad, India, 382428
Not Yet Recruiting
61
KLES Dr. Prabhakar Kore Hospital & M.R.C
Belagavi, India, 590010
Not Yet Recruiting
62
Belagavi Institute of Medical Sciences - Belagavi
Belgavi, India, 590019
Not Yet Recruiting
63
All India Institute of Medical Sciences
Bhubaneswar, India, 751019
Not Yet Recruiting
64
Postgraduate Institute of Medical Education & Research
Chandigarh, India, 160012
Not Yet Recruiting
65
Apollo Hospitals - Chennai
Chennai, India, 600006
Not Yet Recruiting
66
Malla Reddy Narayana Multispeciality Hospital
Hyderabad, India, 500055
Not Yet Recruiting
67
Ketki Nursing Home & Urology Hospital
Nagpur, India, 440012
Not Yet Recruiting
68
Sir Ganga Ram Hospital
New Delhi, India, 110060
Not Yet Recruiting
69
Lifepoint Multispeciality Hospital
Pune, India, 411057
Not Yet Recruiting
70
All India Institute of Medical Sciences
Raipur, India, 492099
Not Yet Recruiting
71
All India Institute of Medical Sciences - Rishikesh
Rishikesh, India, 249203
Not Yet Recruiting
72
Surat Institute of Digestive Sciences Hospitals
Surat, India, 395002
Not Yet Recruiting
73
Banaras Hindu University
Varanasi, India, 221005
Not Yet Recruiting
74
Hasegawa Hospital - Arakawa
Arakawa City, Japan, 116-0014
Actively Recruiting
75
Takasu Nephrology and Urology Clinic
Chiba, Japan, 261-0004
Actively Recruiting
76
Yotsuya Medical Cube
Chiyoda City, Japan, 102-0084
Actively Recruiting
77
St. Luke's International Hospital
Chūōku, Japan, 104-8560
Actively Recruiting
78
Mito Medical Center
Higashiibaraki, Japan, 311-3117
Actively Recruiting
79
Nihon University Itabashi Hospital
Itabashiku, Japan, 173-8610
Not Yet Recruiting
80
Kokura Memorial Hospital
Kitakyushu, Japan, 802-8555
Actively Recruiting
81
Touyu Clinic
Matsudo, Japan, 270-0034
Actively Recruiting
82
Tokyo Saiseikai Central Hospital
Minatoku, Japan, 108-0073
Actively Recruiting
83
Koujunkai Daido Clinic
Nagoya, Japan, 457-8511
Actively Recruiting
84
Women's Clinic LUNA NEXT STAGE
Naka-ku, Yokohama-Shi, Japan, 231-0861
Actively Recruiting
85
Chiba Saiseikai Narashino hospital
Narashino, Japan, 275-8580
Not Yet Recruiting
86
Nakazawa Nephrology and Urology Clinic
Nonoichi, Japan, 921-8824
Actively Recruiting
87
Miyabi Urogyne Clinic
Okayama, Japan, 700-0822
Actively Recruiting
88
Nakatsu Hospital
Osaka, Japan, 530-0012
Actively Recruiting
89
Yukigaya Urology Clinic
Ōta-ku, Japan, 145-0065
Actively Recruiting
90
Kashiwazaki Obstetrics and Gynecology Clinic
Saitama-shi, Japan, 330-0855
Actively Recruiting
91
Izumi Chuo Hospital
Sendai, Japan, 981-3121
Actively Recruiting
92
Toride Urology Clinic
Toride, Japan, 302-0021
Actively Recruiting
93
Tsukuba Urocare Clinic
Tsukuba, Japan, 305-0821
Actively Recruiting
94
Medical Center Metas
Chihuahua City, Mexico, 31110
Actively Recruiting
95
Scientia Investigacion Clinica S.C.
Chihuahua City, Mexico, 31207
Actively Recruiting
96
Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, S.C.
Ciudad Madero, Mexico, 89440
Actively Recruiting
97
Health Pharma Querétaro
Juriquilla, Mexico, 76230
Actively Recruiting
98
RM Pharma Specialists - Unidad Especializada en Datos
Mexico City, Mexico, 03100
Actively Recruiting
99
Centro de Oncología de Precisión - Mexico City
Mexico City, Mexico, 03330
Not Yet Recruiting
100
Quemex Medical and Research
Mexico City, Mexico, 14308
Not Yet Recruiting
101
Medical Care and Research SA de CV
Mérida, Mexico, 97070
Actively Recruiting
102
Clinstile, S.A. de C.V.
México, Mexico, 06700
Not Yet Recruiting
103
Jose Gerardo Garza Leal
Monterrey, Mexico, 64060
Not Yet Recruiting
104
Centro de investigación y control metabólico
Monterrey, Mexico, 66465
Actively Recruiting
105
Centro de Investigacion Clinica Chapultepec
Morelia, Mexico, 58260
Not Yet Recruiting
106
Medimanage Research
Tlalpan, Mexico, 14050
Actively Recruiting
107
IN VIVO
Bydgoszcz, Poland, 85-048
Actively Recruiting
108
AIDPORT Sp. z o.o.
Skórzewo, Poland, 60-185
Actively Recruiting
109
Centrum Medyczne Euromedis
Szczecin, Poland, 70-111
Actively Recruiting
110
Medical Concierge Centrum Medyczne
Warsaw, Poland, 02-798
Actively Recruiting
111
Centrum Medyczne Ginemedica
Wroclaw, Poland, 50-414
Actively Recruiting
112
EMC Instytut Medyczny SA
Wroclaw, Poland, 54-239
Actively Recruiting
113
Centrul Medical Unirea
Brasov, Romania, 500091
Actively Recruiting
114
Spitalul Clinic Judetean de Urgenta (Brasov)
Brasov, Romania, 500152
Actively Recruiting
115
Spitalul Clinic de Nefrologie Doctor Carol Davila
Bucharest, Romania, 010731
Actively Recruiting
116
Spitalul Universitar de Urgenta Militar Central Dr. Carol Davila
Bucharest, Romania, 010825
Not Yet Recruiting
117
Delta Health Care
Bucharest, Romania, 014142
Actively Recruiting
118
Spitalul Clinic Colentina
Bucharest, Romania, 020125
Actively Recruiting
119
Spitalul de Urgenta al Ministerului Administratiei si Internelor "Prof. Dr. Dimitrie Gerota"
Bucharest, Romania, 021373
Actively Recruiting
120
Spitalul Clinic Județean de Urgență Ilfov
Bucharest, Romania, 022105
Actively Recruiting
121
Fundeni Clinical Institute
Bucharest, Romania, 022328
Actively Recruiting
122
Gnosis Evomed S.R.L.
Bucharest, Romania, 030913
Actively Recruiting
123
Spitalul Clinic Profesor Doctor Theodor Burghele
Bucharest, Romania, 050659
Actively Recruiting
124
Spitalul Clinic Județean de Urgență
Craiova, Romania, 200642
Actively Recruiting
125
Spitalul Clinic Judetean De Urgenta Bihor
Oradea, Romania, 410169
Not Yet Recruiting
126
Clinica Polisano
Sibiu, Romania, 550253
Not Yet Recruiting
127
Polaris Medical SA
Suceagu, Romania, 407062
Actively Recruiting
128
S.C. Materna Care S.R.L.
Timișoara, Romania, 300645
Actively Recruiting
129
Spitalul Clinic Judeţean de Urgenţă Pius Brînzeu Timişoara
Timișoara, Romania, 300723
Actively Recruiting
130
Hallym University Sacred Heart Hospital
Anyang-si, South Korea, 14068
Actively Recruiting
131
The Catholic University of Korea, Bucheon St. Mary's Hospital
Bucheon-si, South Korea, 14647
Actively Recruiting
132
Pusan National University Hospital
Busan, South Korea, 49241
Actively Recruiting
133
Chonnam National University Hospital
Gwangju, South Korea, 61469
Actively Recruiting
134
Kyungpook National University Hospital
Junggu, South Korea, 41944
Actively Recruiting
135
Severance Hospital, Yonsei University Health System
Seoul, South Korea, 03722
Actively Recruiting
136
Samsung Medical Center
Seoul, South Korea, 06351
Actively Recruiting
Research Team
T
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
P
Physicians interested in becoming principal investigators please contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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