Actively Recruiting
A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
Led by Eli Lilly and Company · Updated on 2025-11-05
125
Participants Needed
37
Research Sites
119 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The main purpose of this study, performed under Master Protocol J4M-MC-PWMP, is to evaluate the efficacy, safety, and pharmacokinetics of orforglipron once daily oral versus Placebo in adolescent participants with obesity, or overweight with related comorbidities. Participation in the study will last about 18 months.
CONDITIONS
Official Title
A Study of Orforglipron (LY3502970) in Adolescent Participants With Obesity, or Overweight With Related Comorbidities
Who Can Participate
Eligibility Criteria
You may qualify if you...
- History of at least one unsuccessful effort to lose sufficient body weight after at least 3 months of diet and exercise counseling
- Obesity defined as BMI at or above the 95th percentile for age and sex according to CDC-NCHS 2022 growth charts
- OR overweight defined as BMI between the 85th and 95th percentile for age and sex with at least one weight-related comorbidity including hypertension, type 2 diabetes, prediabetes, dyslipidemia, obstructive sleep apnea, metabolic dysfunction-associated steatohepatitis (MASH), or metabolic dysfunction-associated steatotic liver disease (MASLD)
You will not qualify if you...
- Prepubertal stage (Tanner stage 1)
- Weight loss greater than 5 kilograms (11 pounds) within 90 days before screening
- Undergoing or planning weight reduction surgery such as gastric bypass, sleeve gastrectomy, Lap-Band gastric banding, or other weight reduction procedures
- Diagnosis or history of secondary causes of obesity including hypothalamic, monogenetic, syndromic, or endocrine causes
- Type 1 diabetes or history of ketoacidosis or hyperosmolar state
- HbA1c above 9.0% as measured at screening
- Family or personal history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia Syndrome Type 2
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 37 locations
1
Carey Chronis MD Pediatric, Infant and Adolescent Medicine
Ventura, California, United States, 93003-5369
Actively Recruiting
2
Yale School of Medicine - Yale Diabetes Center (YDC)) Trials
New Haven, Connecticut, United States, 06519
Not Yet Recruiting
3
Stamford Therapeutics Consortium
Stamford, Connecticut, United States, 06905
Actively Recruiting
4
Children's Healthcare of Atlanta - Center for Advanced Pediatrics
Atlanta, Georgia, United States, 30329
Actively Recruiting
5
Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, United States, 60611
Actively Recruiting
6
Velocity Clinical Research
Lafayette, Louisiana, United States, 70508
Actively Recruiting
7
MedPharmics, LLC
Gulfport, Mississippi, United States, 39503-2637
Actively Recruiting
8
Sundance Clinical Research
St Louis, Missouri, United States, 63141-7068
Actively Recruiting
9
Lucas Research, Inc.
Morehead City, North Carolina, United States, 28557
Actively Recruiting
10
Childrens Hospital of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15224
Actively Recruiting
11
Vanderbilt Health One Hundred Oaks
Nashville, Tennessee, United States, 37204
Not Yet Recruiting
12
Dynamed Clinical Research, LP d/b/a DM Clinical Research
Houston, Texas, United States, 77065
Actively Recruiting
13
La Providence Pediatrics Clinic - Chemidox Clinical Trials
Houston, Texas, United States, 77071-1008
Actively Recruiting
14
Martin Diagnostic Clinic
Tomball, Texas, United States, 77375-3332
Actively Recruiting
15
Velocity Clinical Research, Salt Lake City
South Jordan, Utah, United States, 84088
Actively Recruiting
16
Shamir Medical Center
Beer Jacob, Israel, 73100
Actively Recruiting
17
Shaare Zedek Medical Center
Jerusalem, Israel, 9013102
Actively Recruiting
18
Sheba Medical Center
Ramat Gan, Israel, 52621
Actively Recruiting
19
Azienda Ospedaliero Universitaria Meyer
Florence, Italy, 50139
Actively Recruiting
20
Azienda Ospedaliero Universitaria Maggiore della Carità
Novara, Italy, 28100
Actively Recruiting
21
Ospedale Pediatrico Bambino Gesù
Roma, Italy, 165
Not Yet Recruiting
22
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento
Verona, Italy, 37126
Actively Recruiting
23
Saitama Medical University Hospital
Iruma-Gun, Japan, 350-0495
Actively Recruiting
24
Osaka City General Hospital
Osaka, Japan, 534-0021
Actively Recruiting
25
Sagaekiminami Clinic
Saga, Japan, 840-0801
Actively Recruiting
26
Shikoku Medical Center for Children and Adults
Zentsujichó, Japan, 765-8507
Actively Recruiting
27
Krakowskie Centrum Medyczne - FutureMeds
Krakow, Poland, 31-501
Actively Recruiting
28
FutureMeds - Targowek
Warsaw, Poland, 03-291
Actively Recruiting
29
Instytut Diabetologii - Warsaw
Warszewo, Poland, 2117
Actively Recruiting
30
FutureMeds sp. z o. o.
Wroclaw, Poland, 53-673
Active, Not Recruiting
31
Barnsley Hospital NHS Foundation Trust
Barnsley, United Kingdom, S75 2EP
Actively Recruiting
32
Bristol Royal Hospital for Children
Bristol, United Kingdom, BS2 8BJ
Not Yet Recruiting
33
Addenbrookes Hospital
Cambridge, United Kingdom, CB2 0QQ
Actively Recruiting
34
Ninewells Hospital
Dundee, United Kingdom, DD1 9SY
Actively Recruiting
35
Northwick Park Hospital
Harrow, United Kingdom, HA1 3UJ
Actively Recruiting
36
Hull Royal Infirmary
Hull, United Kingdom, HU3 2JZ
Actively Recruiting
37
Alder Hey Children's Hospital
Liverpool, United Kingdom, L13 0BH
Not Yet Recruiting
Research Team
T
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
P
Physicians interested in becoming principal investigators please contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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