Actively Recruiting
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
Led by Eli Lilly and Company · Updated on 2026-05-14
800
Participants Needed
95
Research Sites
137 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The GZPT master protocol will support two independent studies, J2A-MC-GZT1 and J2A-MC-GZT2. Each study will see how well and safely orforglipron works in people with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 74 weeks.
CONDITIONS
Official Title
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have a body mass index (BMI) of 27 kilograms per square meter (kg/m2) or higher at screening
- Have tried at least once to lose weight through diet but were unsuccessful
- Have osteoarthritis of the knee and at least one of the following: be over 50 years old; have morning knee stiffness lasting about 30 minutes; or have a crackling or grinding sound or feeling in the knee
You will not qualify if you...
- Have gained or lost more than 11 pounds within 90 days prior to screening
- Have had or plan to have surgery for obesity in the next 18 months
- Have an active knee infection
- Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
- Have had a recent heart condition or New York Heart Association Functional Classification Class IV congestive heart failure
- Have used any glucagon-like peptide-1 (GLP-1) receptor agonist medication within 180 days of screening
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 95 locations
1
Arizona Research Center
Phoenix, Arizona, United States, 85053
Actively Recruiting
2
AMR Clinical
Tempe, Arizona, United States, 85281
Actively Recruiting
3
Care Access - Huntington Beach
Huntington Beach, California, United States, 92648
Actively Recruiting
4
Care Access - Thousand Oaks
Thousand Oaks, California, United States, 91360
Actively Recruiting
5
Legacy Clinical Trials
Colorado Springs, Colorado, United States, 80909
Actively Recruiting
6
Chase Medical Research, LLC
Waterbury, Connecticut, United States, 06708
Actively Recruiting
7
Care Access - Decatur
Decatur, Georgia, United States, 30030
Actively Recruiting
8
North Georgia Clinical Research
Woodstock, Georgia, United States, 30189
Actively Recruiting
9
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
10
AMR Clinical
Newton, Kansas, United States, 67114
Actively Recruiting
11
MedVadis Research Corporation
Waltham, Massachusetts, United States, 02451
Actively Recruiting
12
StudyMetrix Research
City of Saint Peters, Missouri, United States, 63303
Actively Recruiting
13
AMR Clinical
Kansas City, Missouri, United States, 64114
Actively Recruiting
14
Cardio Metabolic Institute
Somerset, New Jersey, United States, 08873
Actively Recruiting
15
Carolina Research Center
Shelby, North Carolina, United States, 28150
Actively Recruiting
16
University Orthopedics Center
Altoona, Pennsylvania, United States, 16602
Actively Recruiting
17
Care Access - Rapid City
Rapid City, South Dakota, United States, 57701
Actively Recruiting
18
AMR Clinical
Knoxville, Tennessee, United States, 37909
Actively Recruiting
19
Mercy Family Clinic
Dallas, Texas, United States, 75208
Actively Recruiting
20
Juno Research
Houston, Texas, United States, 77040
Actively Recruiting
21
Biopharma Informatic, LLC
Houston, Texas, United States, 77084
Actively Recruiting
22
Activian Clinical Research
Kingwood, Texas, United States, 77339
Actively Recruiting
23
Advanced Rheumatology of Houston - Woodlands
The Woodlands, Texas, United States, 77382
Actively Recruiting
24
Charlottesville Medical Research
Charlottesville, Virginia, United States, 22911
Actively Recruiting
25
Gershon Pain Specialists
Virginia Beach, Virginia, United States, 23454
Actively Recruiting
26
Northwest Clinical Research Center
Bellevue, Washington, United States, 98007
Actively Recruiting
27
Aggarwal and Associates Limited
Brampton, Canada, L6T 0G1
Actively Recruiting
28
Diex Recherche Inc. Division Joliette
Joliette, Canada, J6E 6A9
Actively Recruiting
29
Your Research Network
Niagara Falls, Canada, L2H 1H5
Actively Recruiting
30
G.R.M.O. (Groupe de recherche en maladies osseuses) Inc.
Québec, Canada, G1V 3M7
Actively Recruiting
31
Alpha Recherche Clinique
Québec, Canada, G2J 0C4
Actively Recruiting
32
ALPHA Recherche Clinique
Québec, Canada, G3K 2P8
Actively Recruiting
33
Bluewater Clinical Research Group Inc.
Sarnia, Canada, N7T 4X3
Actively Recruiting
34
Winterberry Research Inc.
Stoney Creek, Canada, L8J 0B6
Actively Recruiting
35
Dr. M.B. Jones Inc.
Victoria, Canada, V8V 4A1
Not Yet Recruiting
36
The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technolo -T
Baotou, China, 014010
Actively Recruiting
37
Xuanwu Hospital Capital Medical University
Beijing, China, 100053
Actively Recruiting
38
The Second Affiliated Hospital Chongqing Medical University
Chongqing, China, 400010
Actively Recruiting
39
The Fourth Affiliated Hospital of Harbin Medical University
Harbin, China, 150001
Actively Recruiting
40
The Second People's Hospital of Hefei
Hefei, China, 230011
Actively Recruiting
41
Jinan Central Hospital
Jinan, China, 250013
Actively Recruiting
42
The First Affiliated Hospital of Henan University of Science &Technology
Luoyang, China, 471003
Actively Recruiting
43
Jiangsu Province Hospital
Nanjing, China, 210029
Actively Recruiting
44
Nanjing Medical University - Nanjing Jiangning Hospital
Nanjing, China, 211100
Not Yet Recruiting
45
Pingxiang People's Hospital
Pingxiang, China, 337055
Actively Recruiting
46
The First Hospital of Qinhuangdao
Qinhuangdao Shi, China, 066000
Not Yet Recruiting
47
Huashan Hospital, Fudan University
Shanghai, China, 200040
Actively Recruiting
48
The First Affiliated Hospital of Shantou University Medical College
Shantou, China, 515041
Actively Recruiting
49
The University of Hong Kong-Shenzhen Hospital
Shenzhen, China, 518053
Actively Recruiting
50
Taizhou Hospital of Zhejiang Province
Taizhou, China, 317000
Not Yet Recruiting
51
Klinische Forschung Berlin-Mitte
Berlin, Germany, 10117
Not Yet Recruiting
52
Siteworks GmbH - Bochum
Bochum, Germany, 44787
Actively Recruiting
53
Klinische Forschung Dresden
Dresden, Germany, 01069
Actively Recruiting
54
HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg GmbH / -T
Hamburg, Germany, 20095
Actively Recruiting
55
Klinische Forschung Hamburg
Hamburg, Germany, 20253
Actively Recruiting
56
Klinische Forschung Hannover-Mitte
Hanover, Germany, 30159
Actively Recruiting
57
Siteworks GmbH - Hannover
Hanover, Germany, 30449
Actively Recruiting
58
Klinische Forschung Karlsruhe
Karlsruhe, Germany, 76137
Actively Recruiting
59
Siteworks - Karlsruhe
Karlsruhe, Germany, 76137
Actively Recruiting
60
AmBeNet GmbH
Leipzig, Germany, 04107
Actively Recruiting
61
CDG Studienambulanz Hartard
München, Germany, 80809
Actively Recruiting
62
Dedicated Research Site FutureMeds
Offenbach, Germany, 63065
Actively Recruiting
63
Private Practice - Dr. Jochen Walter
Rendsburg, Germany, 24768
Actively Recruiting
64
Universitaetsklinikum Wuerzburg
Würzburg, Germany, 97074
Actively Recruiting
65
All India Institute of Medical Sciences
Bhubaneswar, India, 751019
Not Yet Recruiting
66
Rajiv Gandhi Government General Hospital
Chennai, India, 600003
Not Yet Recruiting
67
Atmaram Child Care
Kanpur, India, 208011
Not Yet Recruiting
68
Kims Kingsway Hospital
Nagpur, India, 440001
Not Yet Recruiting
69
Maulana Azad Medical College and Associated with Lok Nayak Hospital
New Delhi, India, 110002
Not Yet Recruiting
70
Vencer Hospital
Pimpri-Chinchwad, India, 411027
Not Yet Recruiting
71
Hamanomachi Hospital
Fukuoka, Japan, 810-8539
Actively Recruiting
72
Fukuoka Wajiro Hospital
Fukuoka, Japan, 811-0213
Actively Recruiting
73
Shimane University Hospital
Izumo, Japan, 693-8501
Actively Recruiting
74
Kariya Toyota General Hospital
Kariya, Japan, 448-8505
Actively Recruiting
75
Ando Orthopedic
Kawasaki, Japan, 213-0001
Actively Recruiting
76
Tokyo Saiseikai Central Hospital
Minatoku, Japan, 108-0073
Actively Recruiting
77
Goto Orthopedic Surgery Clinic
Miyazaki, Japan, 880-0835
Actively Recruiting
78
Kato Orthopedic Clinic
Morioka, Japan, 020-0021
Actively Recruiting
79
Japan Community Health Care Organization - Saitama Medical Center
Saitama, Japan, 330-0074
Actively Recruiting
80
Sapporo Maruyama Orthopedic Hospital
Sapporo, Japan, 060-0007
Actively Recruiting
81
Masumoto Orthopedics Clinic
Suginami City, Japan, 167-0051
Actively Recruiting
82
Investigacion y Biomedicina de Chihuahua
Chihuahua City, Mexico, 31000
Actively Recruiting
83
Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, S.C.
Ciudad Madero, Mexico, 89440
Actively Recruiting
84
Centro Medico del Angel
Mexicali, Mexico, 21100
Actively Recruiting
85
Kohler & Milstein Research S.A. De C.V.
Mérida, Mexico, 97070
Actively Recruiting
86
IMED Internal Medicine Clin Trials
Monterrey, Mexico, 64020
Actively Recruiting
87
Clínica García Flores SC
Monterrey, Mexico, 64610
Actively Recruiting
88
Hospital San Rafael - La Coruña
A Coruña, Spain, 15006
Actively Recruiting
89
Hospital Universitari Vall d'Hebron
Barcelona, Spain, 08035
Actively Recruiting
90
Hospital Quirón Málaga
Málaga, Spain, 29004
Actively Recruiting
91
Hospital Universitario Marqués de Valdecilla
Santander, Spain, 39008
Actively Recruiting
92
Clínica Gaias - Santiago
Santiago de Compostela, Spain, 15702
Actively Recruiting
93
Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)
Seville, Spain, 41003
Actively Recruiting
94
Hospital Quiron Infanta Luisa
Seville, Spain, 41010
Actively Recruiting
95
Hospital Clínico Universitario de Valladolid
Valladolid, Spain, 47010
Actively Recruiting
Research Team
T
Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
CONTACT
P
Physicians interested in becoming principal investigators please contact
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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