Actively Recruiting
Study of Orphenadrine' in the Treatment of Muscle Cramps in Patients With Cirrhosis
Led by Sherief Abd-Elsalam · Updated on 2019-06-07
100
Participants Needed
1
Research Sites
726 weeks
Total Duration
On this page
Sponsors
S
Sherief Abd-Elsalam
Lead Sponsor
T
Tanta University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Muscle cramps are common in patients with liver disease and associated with significantly diminished quality of life. Patients with cirrhosis often experience muscle cramps with varied frequency and severity. The exact mechanisms by which they occur remain unclear, although a number of pathophysiological events unique to liver disease may contribute. Clinical studies have identified alterations in 3 areas: nerve function, energy metabolism, and plasma volume/electrolytes (1) Orphenadrine is an anticholinergic drug with prominent central nervous system (CNS) and peripheral actions used to treat painful muscle spasms and other similar conditions. The combination of anticholinergic effects and CNS penetration make orphenadrine useful for pain of all etiologies, including from: radiculopathy, muscles, and headaches. \[3,4\]
CONDITIONS
Official Title
Study of Orphenadrine' in the Treatment of Muscle Cramps in Patients With Cirrhosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Cirrhosis
- Muscle cramps occurring 3 or more times per week
You will not qualify if you...
- Allergy to orphenadrine
- Renal impairment
- Pregnant or breastfeeding women
- Peripheral vascular disease
- Peripheral neuropathy
- Taking calcium channel blockers, conjugated estrogens, or naproxen
- Glaucoma
- Prostatic enlargement
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Tanta university hospital
Tanta, Egypt
Actively Recruiting
Research Team
S
Sherief M Abd-Elsalam, lecturer
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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