Actively Recruiting
Study on 30 Outpatients With Chronic Migraine Treated With Well-Being Therapy or With a Control Therapy
Led by University of Florence · Updated on 2026-05-05
30
Participants Needed
2
Research Sites
430 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Chronic migraine is a disabling type of migraine and is often resistant to treatment. Non-pharmacological interventions have been investigated as potential treatment although, unfortunately, the literature on their efficacy is poor and showed mixed results. Well-Being Therapy (WBT) is a brief psychotherapy which has shown efficacy in decreasing the relapse rates of depression in adults, in generalized anxiety disorder and in cyclothymia. It can be implemented to empower psychological well-being. The aim of the present study is to test the efficacy of WBT in a sample of patients with chronic migraine to verify if it reduces the disability due to migraine and distress, it increases the psychological well-being as well as the level of euthymia.
CONDITIONS
Official Title
Study on 30 Outpatients With Chronic Migraine Treated With Well-Being Therapy or With a Control Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able and willing to participate with signed informed consent
- Aged 18 to 65 years
- Italian native speaker
- Diagnosed with chronic migraine per International Classification of Headache Disorders, with unilateral pulsating moderate/severe pain aggravated by routine activities and accompanied by nausea/vomiting, light and sound sensitivity, with headaches on 15 or more days per month
- Headache chronicity for at least 1 year with stable symptoms for at least 6 months
- No or stable pharmacological or dietary supplement treatment for chronic migraine for at least 3 months
- Psychotropic medication allowed if stable for at least 3 months
You will not qualify if you...
- Diagnosis of medication overuse headache
- Presence of psychiatric disorders diagnosed by MINI International Neuropsychiatric Interview per DSM-5
- Presence of chronic unstable medical conditions
- Pregnant or breastfeeding
- Receiving exogenous hormone treatment such as hormonal contraceptives or postmenopausal hormone therapy
- Any other condition that may affect ability to follow study procedures as judged by investigators
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Fiammetta COSCI
Florence, Florence, Italy, 50135
Not Yet Recruiting
2
Centro Cefalee e Farmacologia Clinica
Florence, Italy, Italy
Actively Recruiting
Research Team
F
Fiammetta COSCI, Prof.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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