Actively Recruiting
Study on the Pathogenesis and Reversal Strategies of Cancer Cachexia Based on Multi-Omics
Led by China Medical University, China · Updated on 2026-04-09
1000
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Cancer cachexia is a complex systemic metabolic syndrome with high incidence and mortality rates, significantly impacting the prognosis and survival of cancer patients.Current clinical comprehensive intervention approaches can only provide transient symptom relief and fail to fundamentally block or reverse muscle and fat loss. The core challenge lies in the extreme complexity of this pathological mechanism and the lack of early biomarkers.To overcome the limitations of traditional single-dimensional research approaches, this study proposes a combined analysis method utilizing "multi-omics" (imaging omics, pathological omics, metabolomics, and metagenomics) to construct a panoramic systemic model spanning macroscopic clinical manifestations and microscopic molecular processes. The aim is to comprehensively elucidate the pathogenesis and metabolic pathways of cachexia, thereby precisely identifying potential therapeutic targets capable of reversing this pathological process.
CONDITIONS
Official Title
Study on the Pathogenesis and Reversal Strategies of Cancer Cachexia Based on Multi-Omics
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Signed informed consent and voluntary participation
- Confirmed diagnosis of cancer by histology or cytology
- Diagnosis of gastrointestinal cancers including esophageal cancer, hepatocellular carcinoma, gastric cancer, or cholangiocarcinoma
- Undergoing biopsy of primary lesion or gastrointestinal endoscopic biopsy
You will not qualify if you...
- Pregnant or breastfeeding women
- Contraindications for surgery
- Cognitive dysfunction, psychiatric disorders, impaired consciousness, or unwillingness/inability to cooperate
- Having two or more concurrent primary tumors
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The First Affiliated Hospital of China Medical University
Shenyang, Liaoning, China
Actively Recruiting
Research Team
H
Hanwen Liu
CONTACT
X
XiaoXu Liu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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