Actively Recruiting
Study in Patients With Breast Cancer Leptomeningeal Metastasis
Led by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Updated on 2025-11-28
30
Participants Needed
2
Research Sites
209 weeks
Total Duration
On this page
Sponsors
S
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Lead Sponsor
A
Avon Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
Traditional clinical trials in patients with breast cancer leptomeningeal disease (LMD) are challenging as patients often have a rapidly progressive course and prognosis is poor, making meeting standard eligibility difficult. Furthermore, there is limited information about the biology of LMD. The investigators thus propose a study that is as inclusive as possible, which will allow the investigators to collect biospecimens and clinical outcomes to learn more about LMD biology, but still potentially provide benefit for patients, by providing patients rapid diagnostics and multi-disciplinary treatment recommendations.
CONDITIONS
Official Title
Study in Patients With Breast Cancer Leptomeningeal Metastasis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female, aged 18 or older
- History of breast cancer (any subtype)
- Suspected breast cancer-related leptomeningeal metastasis by clinical signs, radiographic, or cerebrospinal fluid analysis
- Patient will be treated along a leptomeningeal disease paradigm
- Previous central nervous system metastasis is eligible
- Eastern Cooperative Oncology Group (ECOG) score of �3 or Karnofsky performance status �60
You will not qualify if you...
- Suspected central nervous system recurrence of hematologic malignancy, lymphoma, or other solid tumor
- Not eligible for treatment of leptomeningeal disease
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 2 locations
1
Sibley Memorial Hospital
Washington D.C., District of Columbia, United States, 20016
Not Yet Recruiting
2
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, United States, 21287
Actively Recruiting
Research Team
H
Hopkins Breast Trials
CONTACT
S
Sidney Kimmel Cancer Center Clinical Research Office
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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