Actively Recruiting
Study of Patritumab Deruxtecan in Participants With Gastrointestinal Cancers (MK-1022-011) (HERTHENA-PanTumor02)
Led by Merck Sharp & Dohme LLC · Updated on 2026-04-23
180
Participants Needed
62
Research Sites
213 weeks
Total Duration
On this page
Sponsors
M
Merck Sharp & Dohme LLC
Lead Sponsor
D
Daiichi Sankyo
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers want to learn if patritumab deruxtecan (MK-1022) can treat certain gastrointestinal (GI) cancers. The GI cancers being studied are advanced (the cancer has spread to other parts of the body). The goals of this study are to learn: * About the safety and how well people tolerate of patritumab deruxtecan * How many people have the cancer respond (get smaller or go away) to treatment
CONDITIONS
Official Title
Study of Patritumab Deruxtecan in Participants With Gastrointestinal Cancers (MK-1022-011) (HERTHENA-PanTumor02)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Has unresectable or metastatic colorectal cancer
- Has advanced and/or unresectable biliary tract cancer
- Has hepatocellular carcinoma not amenable to locoregional therapy
- Has locally advanced unresectable or metastatic gastroesophageal cancer
- Has received prior therapy for the cancer
- Has recovered from side effects of previous cancer treatment
You will not qualify if you...
- History of noninfectious interstitial lung disease or pneumonitis requiring steroids
- Current or suspected interstitial lung disease or pneumonitis not ruled out
- Clinically severe respiratory compromise from lung illnesses
- Evidence of leptomeningeal disease
- Clinically significant corneal disease
- Uncontrolled significant cardiovascular or cerebrovascular disease
- Ongoing uncontrolled systemic bacterial, fungal, or viral infection
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 62 locations
1
UCLA Hematology Oncology Santa Monica ( Site 1205)
Santa Monica, California, United States, 90404
Actively Recruiting
2
University of Colorado Cancer Center ( Site 1200)
Aurora, Colorado, United States, 80045
Actively Recruiting
3
Sibley Memorial Hospital ( Site 1208)
Washington D.C., District of Columbia, United States, 20016
Actively Recruiting
4
University of Florida ( Site 1202)
Gainesville, Florida, United States, 32610
Actively Recruiting
5
Mount Sinai Medical Center Comprehensive Cancer Center ( Site 1213)
Miami Beach, Florida, United States, 33140
Actively Recruiting
6
Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital-Research ( Site 1203)
Marietta, Georgia, United States, 30060
Completed
7
University of Chicago Medical Center ( Site 1204)
Chicago, Illinois, United States, 60637
Actively Recruiting
8
Renown Regional Medical Center ( Site 1221)
Reno, Nevada, United States, 89502
Actively Recruiting
9
NYU Langone Hospital - Long Island ( Site 1230)
Mineola, New York, United States, 11501
Actively Recruiting
10
Perlmutter NYU Cancer Center ( Site 1212)
New York, New York, United States, 10016
Actively Recruiting
11
Scott & White Medical Center-Temple ( Site 1224)
Temple, Texas, United States, 76508
Actively Recruiting
12
Oncology and Hematology Associates of Southwest Virginia (BRCC) ( Site 1207)
Roanoke, Virginia, United States, 24014
Actively Recruiting
13
University of Wisconsin ( Site 1210)
Madison, Wisconsin, United States, 53792
Actively Recruiting
14
Westmead Hospital ( Site 0100)
Sydney, New South Wales, Australia, 2145
Actively Recruiting
15
Alfred Health ( Site 0102)
Melbourne, Victoria, Australia, 3004
Actively Recruiting
16
Austin Health ( Site 0103)
Melbourne, Victoria, Australia, 3084
Actively Recruiting
17
One Clinical Research ( Site 0104)
Mount Pleasant, Western Australia, Australia, 6009
Actively Recruiting
18
QEII Health Sciences Centre - Victoria General Site ( Site 0200)
Halifax, Nova Scotia, Canada, B3H 2Y9
Actively Recruiting
19
Sunnybrook Research Institute - Odette Cancer Centre ( Site 0206)
Toronto, Ontario, Canada, M4N 3M5
Actively Recruiting
20
McGill University Health Centre ( Site 0202)
Montreal, Quebec, Canada, H4A 3J1
Actively Recruiting
21
Fundacion Arturo Lopez Perez ( Site 0301)
Santiago, Region M. de Santiago, Chile, 7500921
Actively Recruiting
22
Centro de Oncología de Precisión ( Site 0305)
Santiago, Region M. de Santiago, Chile, 7560908
Actively Recruiting
23
Clínica UC San Carlos de Apoquindo ( Site 0302)
Santiago, Region M. de Santiago, Chile, 7620002
Actively Recruiting
24
Bradfordhill ( Site 0300)
Santiago, Region M. de Santiago, Chile, 8420383
Actively Recruiting
25
The First Affiliated Hospital of Anhui Medical University ( Site 0405)
Hefei, Anhui, China, 230088
Actively Recruiting
26
Fujian Provincial Cancer Hospital ( Site 0408)
Fuzhou, Fujian, China, 350014
Actively Recruiting
27
Zhongshan Hospital Fudan University (Xiamen Branch) ( Site 0412)
Xiamen, Fujian, China, 361015
Actively Recruiting
28
Southern Medical University Nanfang Hospital ( Site 0413)
Fuzhou, Guangdong, China, 510515
Actively Recruiting
29
The First Affiliated Hospital, Sun Yat-sen University ( Site 0404)
Guangzhou, Guangdong, China, 510080
Actively Recruiting
30
Affiliated Cancer Hospital of Guangxi Medical University ( Site 0411)
Nanning, Guangxi, China, 530201
Actively Recruiting
31
Henan Cancer Hospital ( Site 0403)
Zhengzhou, Henan, China, 450008
Actively Recruiting
32
Zhongshan Hospital,Fudan University ( Site 0400)
Shanghai, Shanghai Municipality, China, 200032
Actively Recruiting
33
First Hospital of Shanxi Medical University ( Site 0409)
Taiyuan, Shanxi, China, 030001
Actively Recruiting
34
Hopital de la Croix Rousse ( Site 0502)
Lyon, Auvergne-Rhône-Alpes, France, 69004
Actively Recruiting
35
Hopital Beaujon ( Site 0500)
Clichy, Hauts-de-Seine, France, 92110
Actively Recruiting
36
Centre Eugène Marquis Rennes - Centre de Lutte Contre le Cancer ( Site 0501)
Rennes, Ille-et-Vilaine, France, 35042
Actively Recruiting
37
Rambam Health Care Campus ( Site 0603)
Haifa, Israel, 3109601
Actively Recruiting
38
Hadassah Medical Center ( Site 0602)
Jerusalem, Israel, 9112001
Actively Recruiting
39
Sourasky Medical Center ( Site 0601)
Tel Aviv, Israel, 6423906
Actively Recruiting
40
Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 0700)
Milan, Italy, 20133
Actively Recruiting
41
ASST Grande Ospedale Metropolitano Niguarda ( Site 0701)
Milan, Italy, 20162
Actively Recruiting
42
Fondazione Policlinico Universitario Agostino Gemelli ( Site 0702)
Roma, Italy, 00168
Actively Recruiting
43
Harbour Cancer & Wellness ( Site 0800)
Auckland, New Zealand, 1023
Actively Recruiting
44
Seoul National University Hospital ( Site 0900)
Seodaemun-gu, Seoul, South Korea, 03080
Actively Recruiting
45
Severance Hospital, Yonsei University Health System ( Site 0903)
Seoul, South Korea, 03722
Actively Recruiting
46
Asan Medical Center ( Site 0902)
Seoul, South Korea, 05505
Actively Recruiting
47
Samsung Medical Center ( Site 0901)
Seoul, South Korea, 06351
Actively Recruiting
48
Hospital Central de Asturias ( Site 1001)
Oviedo, Principality of Asturias, Spain, 33011
Actively Recruiting
49
Hospital Universitari Vall d'Hebron ( Site 1000)
Barcelona, Spain, 08035
Actively Recruiting
50
Hospital Universitario Gregorio Maranon ( Site 1002)
Madrid, Spain, 28007
Actively Recruiting
51
Hospital Clinico San Carlos... ( Site 1003)
Madrid, Spain, 28040
Actively Recruiting
52
Hopitaux Universitaires de Geneve HUG. ( Site 1102)
Geneva, Switzerland, 1211
Actively Recruiting
53
Universitaetsspital Zuerich ( Site 1105)
Zurich, Switzerland, 8091
Actively Recruiting
54
National Cheng Kung University Hospital-Clinical Trial Center ( Site 1502)
Tainan, Taiwan, 704
Actively Recruiting
55
National Taiwan University Hospital ( Site 1500)
Taipei, Taiwan, 10002
Actively Recruiting
56
Taipei Veterans General Hospital ( Site 1501)
Taipei, Taiwan, 112201
Actively Recruiting
57
Faculty of Medicine Siriraj Hospital ( Site 1301)
Bangkoknoi, Bangkok, Thailand, 10700
Actively Recruiting
58
Ramathibodi Hospital ( Site 1302)
Ratchathewi, Bangkok, Thailand, 10400
Actively Recruiting
59
Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi ( Site 1400)
Yenimahalle, Ankara, Turkey (Türkiye), 06200
Actively Recruiting
60
Dokuz Eylul Universitesi Hastanesi ( Site 1402)
Balçova, İzmir, Turkey (Türkiye), 35340
Actively Recruiting
61
Adana City Hospital ( Site 1404)
Adana, Turkey (Türkiye), 01370
Active, Not Recruiting
62
Hacettepe Universite Hastaneleri ( Site 1401)
Ankara, Turkey (Türkiye), 06230
Active, Not Recruiting
Research Team
T
Toll Free Number
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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