Actively Recruiting
A Study of Pembrolizumab and Cryoablation in People With Breast Cancer
Led by Memorial Sloan Kettering Cancer Center · Updated on 2025-05-21
30
Participants Needed
7
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Participants will have a confirmed diagnosis of metastatic breast cancer and will receive pembrolizumab in combination with cryoablation OR pembrolizumab alone. Participants will be randomly assigned.
CONDITIONS
Official Title
A Study of Pembrolizumab and Cryoablation in People With Breast Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years of age or older
- Confirmed histologic diagnosis of metastatic triple-negative breast cancer
- At least one tumor site suitable for cryoablation that is 1.5 cm or larger, as assessed by an interventional radiologist
- Physically fit to undergo cryoablation
- Women of childbearing potential must use effective contraception during and for 4 months after pembrolizumab treatment, with pregnancy testing as required
- Planned pembrolizumab therapy (200 mg every 3 weeks) as first, second, or third line of treatment
- Eligible for PD-1 inhibitor treatment as determined by the patient's medical oncologist
- May receive additional systemic therapies as decided by the medical oncologist, including listed chemotherapy drugs
You will not qualify if you...
- Patient not eligible for PD-1 inhibitor treatment as determined by the medical oncologist
- No tumor suitable for cryoablation
- Pembrolizumab therapy not planned as part of standard care
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
Memorial Sloan Kettering Cancer Center at Basking Ridge (Limited Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth (Limited protocol activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Suffolk-Commack (Limited Protocol Activities )
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
Harrison, New York, United States, 10604
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center (All protocol activites)
New York, New York, United States, 10065
Actively Recruiting
7
Memorial Sloan Kettering Nassau (Limited Protocol Activites)
Rockville Centre, New York, United States, 11553
Actively Recruiting
Research Team
Y
Yolanda Bryce, MD
CONTACT
L
Larry Norton, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here