Actively Recruiting
Study on Multi-Omics Analysis of Peripheral Blood in Patients With Acute Coronary Syndrome
Led by Second Affiliated Hospital of Wenzhou Medical University · Updated on 2025-07-25
310
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
Sponsors
S
Second Affiliated Hospital of Wenzhou Medical University
Lead Sponsor
T
The Central Hospital of Lishui City
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are investigating the changes in various factors such as cell growth factors, inflammatory markers, metabolites, and plasma proteins in the blood of patients with Acute Coronary Syndrome (ACS). The study aims to understand how these changes relate to disease prognosis by comparing the ACS group with those having Chronic Coronary Syndrome (CCS) and a control group without coronary artery or structural heart diseases. Blood samples will be collected within 24 hours of hospital admission to analyze these factors using multi-omics and related research methods. Participants will be categorized into three groups: those with ACS, those with CCS, and a control group without heart disease. Blood samples will be taken promptly after hospital admission to measure levels of fibroblast growth factors, inflammatory cytokines, chemokines, cytochrome C, mitochondrial DNA, and malondialdehyde. The study will also examine the relationships between these markers and clinical indicators such as troponin I, brain natriuretic peptide, lactate dehydrogenase, and left ventricular ejection fraction. During the study, participants will undergo peripheral venous blood collection within 24 hours of admission. Researchers will monitor and analyze various blood markers to evaluate their association with heart disease status and prognosis. The study's main outcomes focus on changes in specific circulating factors and their correlation with heart function measures, helping to better understand the biological processes in ACS and CCS. Participation duration depends on hospital admission timing and sample collection.
CONDITIONS
Brief Title
A Study on the Peripheral Blood in Patients With Acute Coronary Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Diagnosed with STEMI, NSTEMI, or unstable angina for ACS group with specific clinical and laboratory findings
- Clinical diagnosis consistent with Chronic Coronary Syndrome categories for CCS group
- Patients without coronary artery stenosis, valvular heart disease, structural heart disease, or cardiomyopathy for control group
You will not qualify if you...
- Pregnant or breastfeeding women
- Patients with malignant tumors
- Severe liver or kidney dysfunction
- Severe blood disorders
- Autoimmune diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Within 24 hours of admission
Participants undergo blood sample collection within 24 hours of hospital admission to measure circulating factors related to Acute Coronary Syndrome or other heart conditions.
1 visit (in-person)
Duration - Up to study completion
Participants are observed to understand the relationship between blood biomarkers and cardiac health without receiving any intervention.
No additional visits beyond diagnostic evaluation
Trial Site Locations
Total: 1 location
1
Lishui Central Hospital
Lishui, Zhejiang, China
Actively Recruiting
Research Team
C
Chao Niu, Doctor
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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