Actively Recruiting
A Study of PET Adapted Therapy and Non-invasive Monitoring for Previously Untreated Limited Stage Diffuse Large B Cell Lymphoma
Led by University of Rochester · Updated on 2026-02-09
40
Participants Needed
1
Research Sites
420 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The overarching goals of this study are to measure levels of circulating tumor DNA (ctDNA) in patients with early stage diffuse large B cell lymphoma (DLBCL), to assess the change in ctDNA during treatment in order to prospectively identify markers of treatment failure, and to use ctDNA as a future tool for response adapted therapy.
CONDITIONS
Official Title
A Study of PET Adapted Therapy and Non-invasive Monitoring for Previously Untreated Limited Stage Diffuse Large B Cell Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Previously untreated limited stage non bulky diffuse large B cell lymphoma (DLBCL) defined by routine staging including FDG-PET and bone marrow biopsy (Lugano criteria)
- Includes patients with grade 3B follicular lymphoma and transformed indolent lymphoma
- Age 18 years or older
- Measurable disease assessable by FDG-PET
- Access to archived or fresh/frozen tumor biopsies
- No uncontrolled medical comorbidities
- Adequate cardiac function (ejection fraction 50% or higher), no unstable angina
- Adequate kidney function (glomerular filtration rate above 60)
- Adequate liver function (liver tests no greater than 2 times upper limit of normal) including normal bilirubin levels or up to 2 times upper limit if history of Gilbert's disease
- Adequate bone marrow reserves as judged by complete blood count
You will not qualify if you...
- Pregnancy, positive serum HCG within 28 days of enrollment, or breastfeeding
- Bulky disease larger than 10 cm in any dimension
AI-Screening
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Trial Site Locations
Total: 1 location
1
University of Rochester
Rochester, New York, United States, 14642
Actively Recruiting
Research Team
R
Robin Boerman
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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