Study of Plant-Based Diet and Supplements on Gut Butyrate in Adults with Smoldering Multiple Myeloma or MGUS

What this Trial Is About

Researchers are studying how butyrate levels in stool change in people with smoldering multiple myeloma SMM or monoclonal gammopathy of undetermined significance MGUS after following a plant-based diet or taking dietary supplements. The study aims to compare the effects of different dietary changes on stool butyrate to better understand potential impacts on these conditions. Participants are randomly assigned to one of four groups for two weeks omega-3 fatty acid supplements taken twice daily, curcumin supplements taken twice daily, probiotic supplements taken twice daily, or a whole food plant-based diet WFPBD provided through prepared meals and guided by a dietitian. No other dietary changes are made in the supplement groups, and dietary intake data is collected. During the study, participants will complete surveys and use a mobile app to track their diet and stool samples. Researchers will measure the relative abundance of butyrate-producing microbes in stool at two weeks. Participants must have access to a smartphone and live in the United States. The total participation lasts for the two-week intervention period, with monitoring of adherence and safety throughout.

A Study of a Plant-Based Diet and Dietary Supplements in People With Smoldering Multiple Myeloma (SMM) or Monoclonal Gammopathy of Undetermined Significance (MGUS)