Actively Recruiting
Study of the Plasma and Urinary cfDNA of in Kidney Transplant Patients
Led by Poulet Geoffroy · Updated on 2025-04-04
250
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
Sponsors
P
Poulet Geoffroy
Lead Sponsor
U
University Hospital, Rouen
Collaborating Sponsor
AI-Summary
What this Trial Is About
It has been shown that the amount of circulating donor-cell-free DNA increases in patients with transplant rejection. Quantification of single nucleotide polymorphisms (SNPs) present in circulating donor DNA currently allows for early identification of transplant rejection, but not for characterization, i.e., identification of the affected renal fraction of the graft. Recently, in healthy subjects, teams have shown that it is possible to identify the tissue origin of donor-cell-free DNA, based on the epigenetic properties of circulating DNA. CGenetix is a MedTech company developing an in vitro diagnostic medical device to identify and quantify kidney graft degradation during transplant rejection. The objective of this study is to evaluate the sensitivity of the proposed technology to detect circulating renal DNA released into the blood and urine in kidney transplant patients with or without graft rejection.
CONDITIONS
Official Title
Study of the Plasma and Urinary cfDNA of in Kidney Transplant Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients living with a kidney transplant
- Admitted for suspected transplant rejection requiring a renal biopsy (RBB) as an indication
You will not qualify if you...
- Patients with cognitive and mental disorders rendering them unable to express their non-opposition to participation in the study
- Not covered by a social security system
- Under guardianship or legal protection
- Patients who have expressed their refusal to participate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Chu Rouen-Bois Guillaume
Rouen, France, 76230
Actively Recruiting
Research Team
G
GEOFFROY GP POULET, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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