Actively Recruiting
Study of PNPLA3 Genetic Polymorphisms in Patients With Non-Alcoholic Fatty Liver Disease in an Ultramarine Population
Led by Centre Hospitalier Universitaire de la Guadeloupe · Updated on 2026-01-09
600
Participants Needed
3
Research Sites
N/A
Total Duration
On this page
Sponsors
C
Centre Hospitalier Universitaire de la Guadeloupe
Lead Sponsor
C
Centre Hospitalier Universitaire de la Réunion
Collaborating Sponsor
AI-Summary
What this Trial Is About
Metabolic Dysfunction Associated Liver Disease (MASLD) is a common condition linked to metabolic syndrome, with genetic factors like PNPLA3 variants thought to influence liver fat buildup and damage. This research aims to study these genetic variations among MASLD patients in the overseas territories population, primarily of African descent mixed with European and Indian heritage, to better understand their susceptibility to developing the more severe form, Metabolic Dysfunction Associated Steatohepatitis (MASH). The study will analyze genetic samples from adult MASLD patients seen in hospital departments in Guadeloupe, French Guiana, and Réunion Island. Researchers will examine PNPLA3 polymorphisms and assess clinical, imaging, and laboratory markers of MASLD severity at the time of inclusion. This observational study does not involve interventions but focuses on collecting biological samples and health data to explore genetic and clinical profiles. Participants will provide informed consent and undergo assessments including liver imaging and blood tests to evaluate disease stage and fibrosis. Researchers will track allele frequencies of PNPLA3 variants and the distribution of liver disease severity at baseline. The study will also monitor laboratory biomarkers linked to MASLD. The total participation timeline aligns with the inclusion visit, with data collection focused on initial evaluation and genetic analysis.
CONDITIONS
Brief Title
Study of PNPLA3 Genetic Polymorphisms in Patients With Non-Alcoholic Fatty Liver Disease in an Ultramarine Population (AdipoDROMExpo)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients (≥18 years old) seen in consultation or hospitalized in the Hepato-Gastroenterology Departments of the University Hospitals of Guadeloupe, French Guiana, and Réunion Island, with a diagnosis of MASLD.
- MASLD defined as evidence of liver fat associated with overweight/obesity, type 2 diabetes, or metabolic syndrome according to ATP III (2005) criteria.
- Patients affiliated with or beneficiaries of a social security scheme.
- Free, informed, and written consent obtained from the participant and signed by both participant and investigator before any study procedure.
You will not qualify if you...
- Patients under 18 years of age.
- Patients unable to provide informed consent, including vulnerable populations under guardianship or judicial protection.
- Presence of other chronic liver diseases such as viral hepatitis (B, C, or E), primary biliary cholangitis, primary sclerosing cholangitis, autoimmune hepatitis, Wilson's disease, hemochromatosis, alpha-1 antitrypsin deficiency, or alcoholic liver disease.
- Daily alcohol consumption >30 g/day for men or >20 g/day for women.
- Pregnant women.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Baseline visit
Participants undergo assessments to evaluate MASLD clinical stages, liver fibrosis stages by imaging, and MASLD severity based on laboratory biomarkers.
1 visit (in-person)
Duration - Up to study completion
Participants are observed to study the genetic polymorphisms of PNPLA3 and their association with MASLD in the overseas territories population.
Visits according to routine clinical care
Trial Site Locations
Total: 3 locations
1
Centre Hospitalier Universitaire de la Guyane
Cayenne, French Guiana, 97306
Not Yet Recruiting
2
CHU de la Guadeloupe
Pointe-à-Pitre, Guadeloupe, 97159
Actively Recruiting
3
Centre Hospitalier Universitaire de la Réunion
Saint-Denis, Reunion, 97400
Not Yet Recruiting
Research Team
M
melanie petapermal
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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