Actively Recruiting
Study of Probiotics Combined With Concurrent Hyperfractionated ChemoRadiotherapy and Adebrelimab Immunomaintenance in the Treatment of Limited-stage Small Cell Lung Cancer (LS-SCLC)
Led by Fudan University · Updated on 2026-02-11
60
Participants Needed
1
Research Sites
139 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
ADRIATIC study explored the benefits of immune maintenance therapy after LS-SCLC radiotherapy and chemotherapy. In the presence of immunotherapy, is it necessary to increase the dosage of radiotherapy and can it further improve the efficacy? This study aims to explore the efficacy and safety of simultaneous integrated boost hyperfractionation radiotherapy combined with probiotics and Adalberg monoclonal antibody consolidation therapy for small cell lung cancer.
CONDITIONS
Official Title
Study of Probiotics Combined With Concurrent Hyperfractionated ChemoRadiotherapy and Adebrelimab Immunomaintenance in the Treatment of Limited-stage Small Cell Lung Cancer (LS-SCLC)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Signed informed consent before any experimental procedures
- Age between 18 and 80 years old
- Pathological diagnosis of small cell lung cancer
- Limited stage small cell lung cancer
- ECOG performance status of 0 or 1
- Received two or fewer rounds of chemotherapy or chemotherapy plus immunotherapy
- Expected survival time greater than 3 months
You will not qualify if you...
- Disease progression after two induction treatments
- Severe emphysema, interstitial lung changes, or COPD
- Resting blood oxygen level below 93%
- History of other malignant tumors with chemotherapy in the past 3 years
- Previous history of chest radiotherapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, China
Actively Recruiting
Research Team
X
Xingwen Fan
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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