Actively Recruiting
A Study of Probiotics in IgA Nephropathy
Led by University of Leicester · Updated on 2025-01-10
25
Participants Needed
1
Research Sites
137 weeks
Total Duration
On this page
Sponsors
U
University of Leicester
Lead Sponsor
K
Kidney Cancer UK
Collaborating Sponsor
AI-Summary
What this Trial Is About
IgA nephropathy (IgAN) occurs when a specific form of the IgA antibody lodges on the kidneys and causes damage, which may lead to kidney failure. This form of IgA is likely to come from the gut and the upper airways. Recent studies have shown that the bacteria that live in these areas may be different in IgAN. We think that the interaction between these and the immune system triggers production of the IgA that leads to kidney damage. We will examine these bacteria in detail, and test whether a probiotic can alter this favorably, and reduce harmful forms of IgA production in IgAN.
CONDITIONS
Official Title
A Study of Probiotics in IgA Nephropathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Biopsy-proven IgA nephropathy
- Age 18 years or older
- Able and willing to give informed consent
- Sufficient understanding of English to understand patient information and complete questionnaires
- No medication changes for 6 weeks before baseline visit
- Stable diet for 30 days before baseline visit and during the study (no elimination, reduction, vegan, or vegetarian diet changes)
You will not qualify if you...
- Under 18 years of age
- Unable or unwilling to give informed consent
- Estimated glomerular filtration rate (eGFR) below 45 ml/min/1.73 m2
- Regular use of prebiotic, probiotic, or other gut-modulating dietary supplements in the last 60 days
- Expected diet changes during the study
- Autoimmune diseases such as systemic lupus erythematosus
- Serious gastrointestinal illnesses including Crohn's disease, ulcerative colitis, chronic liver disease, significant gastrointestinal surgery or cancer, pancreatitis, or motility disorders
- Infectious illness diagnosed within the past 30 days
- Use of antibiotics, antiviral, steroids, or immunosuppressive medications in the past 60 days
- Any condition that may interfere with the study in the investigator's opinion
- Participation in another clinical trial involving investigational medicinal products
- Allergy to any component of Bio-Kult Advanced, including milk or soy allergy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Leicester General Hospital, University Hospitals of Leicester NHS Trust
Leicester, Leicestershire, United Kingdom, LE5 4PW
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here