Actively Recruiting
Study of Product of Conception Derived From Ultrasound-guided Manual Vacuum Aspiration
Led by Chinese University of Hong Kong · Updated on 2025-03-20
100
Participants Needed
1
Research Sites
283 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Early pregnancy loss is very common, approximately one in four women will experience a miscarriage in their lifetime. The etiology of pregnancy loss remains largely unknown, although genetic, anatomical, endocrinological and immunological abnormalities have been implicated. It is known that embryonic/fetal chromosomal aberrations contributed to approximately 50% of early pregnancy loss, among which 60-70% were aneuploidies, largely can be detected by the current gold standard karyotyping approach recommended by various international societies. However, the drawbacks of conventional karyotyping include the risk of culture failure, maternal cell contamination (MCC), limited detection resolution (5-10 Mb), and differential growth of specific cell lineages which could hinder the diagnosis of genetic abnormalities, particularly mosaicisms. Additional genetic factors beyond the resolution of karyotyping are not well studied.
CONDITIONS
Official Title
Study of Product of Conception Derived From Ultrasound-guided Manual Vacuum Aspiration
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women 18 years old or above
- Women with miscarriage or termination of pregnancy suitable for manual vacuum aspiration
- First trimester miscarriage or termination of pregnancy
- No fetal heartbeat or termination with crown rump length 25 mm or less
- Incomplete miscarriage or termination with pregnancy of gestation less than 5 cm
- Hemodynamically stable
- Able to tolerate speculum examination
You will not qualify if you...
- Not suitable for manual vacuum aspiration procedure
- Cervical stenosis
- Fibroid uterus larger than 12 weeks in size
- Known uterine malformation
- Bleeding disorder
- Clinical sepsis
- Unable to tolerate pelvic examination
- History of psychological or psychiatric problems
- Patient refusal
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Prince of Wales Hospital
Hong Kong, Hong Kong
Actively Recruiting
Research Team
P
Pui Wah Jacqueline Chung
CONTACT
M
Mandie Ho
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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