Actively Recruiting
Study of Progression of Community Acquired Pneumonia in the Hospital in Patients With More Severe Preexisting Diseases and Immunosuppression
Led by Pneumonia Research Network on Genetic Resistance and Susceptibility for the Evolution of Severe Seps · Updated on 2024-03-13
300
Participants Needed
10
Research Sites
313 weeks
Total Duration
On this page
Sponsors
P
Pneumonia Research Network on Genetic Resistance and Susceptibility for the Evolution of Severe Seps
Lead Sponsor
C
Charite University, Berlin, Germany
Collaborating Sponsor
AI-Summary
What this Trial Is About
Pneumonia is a common infectious disease of the lung, often requiring treatment in the hospital. Clinical scoring systems are available, identifying patients not requiring hospitalization. However, the course of disease of patients in the hospital remains hard to predict. While most patients will recover quickly, some will, despite appropriate treatment, develop a severe course leading to sepsis and systemic responses resulting in organ dysfunction. The PROGRESS consortium aims to identify clinical, genetic, and other molecular markers and combinations there of predicting a severe course of pneumonia in the hospital. Such predictors will, for instance, support decisions on earlier transfer of patients to intensive care and thus improving outcome. PROGRESS-COMORB aims to extend findings from the previous PROGRESS study to patients with more severe preexisting conditions and immunosuppression.
CONDITIONS
Official Title
Study of Progression of Community Acquired Pneumonia in the Hospital in Patients With More Severe Preexisting Diseases and Immunosuppression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Hospitalized with community acquired pneumonia confirmed by chest imaging
- Provided valid informed consent
- Diagnosed with community acquired pneumonia by the enrolling physician
- Not hospitalized for any reason within 28 days before current pneumonia hospitalization
- At least two of these symptoms: fever, cough, purulent sputum, shortness of breath or need for respiratory support, crackling or abnormal lung sounds
- At least one of the following: HIV infection or AIDS, anti-tumor treatment within past 6 months, corticosteroid therapy 20mg or more for 14 days or longer, non-steroidal immunosuppressive therapy within past 6 months, cytostatic therapy within past 6 months, radiation therapy within past 6 months, bone marrow transplant, home respiratory support via tracheostoma, cystic fibrosis, severe heart failure (NYHA IV or HFrEF with ejection fraction below 40%), decompensated liver disease (Child-Pugh class C), diabetes with HbA1c 8.5% or higher, end-stage renal disease requiring dialysis, or pulmonary hypertension with mean pulmonary artery pressure over 20 mmHg
You will not qualify if you...
- Participated in this study previously
- Hospitalized more than 48 hours before enrollment (or more than 7 days if admitted directly to intensive care)
- Pregnant
- Breastfeeding
- Active tuberculosis
- Acute lung injury or respiratory distress syndrome caused by non-lung reasons
- Massive aspiration
- Sepsis caused by infection outside the lungs
- Acute pulmonary embolism
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 10 locations
1
Charité - Universitätsmedizin Berlin, Medizinische Klinik m. S. Infektiologie und Pneumologie
Berlin, Germany, 13353
Actively Recruiting
2
Humboldt-Klinikum Vivantes, Kardiologie und kons. Intensivmedizin
Berlin, Germany, 13509
Actively Recruiting
3
Gemeinschaftskrankenhaus Havelhöhe, Kardio-Pneumologie
Berlin, Germany, 14089
Actively Recruiting
4
Städtisches Klinikum Dessau, Innere Medizin
Dessau, Germany, 06847
Actively Recruiting
5
Universitätsklinikum Hamburg Eppendorf, Onkologisches Zentrum, Pneumologische Studienzentrale
Hamburg, Germany, 20246
Actively Recruiting
6
Universitätsklinikum Leipzig, Klinik für Onkologie, Gastroenterologie, Hepatologie, Pneumologie
Leipzig, Germany, 04103
Actively Recruiting
7
Klinikum St. Georg gGmbH, Klinik für Infektions-/Tropenmedizin und Nephrologie
Leipzig, Germany, 04129
Actively Recruiting
8
Universitätsklinikum Gießen und Marburg, Klinik für Pneumologie und Anästhesie
Marburg, Germany, 35043
Actively Recruiting
9
Universitätsklinikum Münster, Kardiologie 1
Münster, Germany, 48149
Actively Recruiting
10
Diakoniekrankenhaus Rotenburg(Wümme)gGmbH, Zentrum für Pneumologie
Rotenburg (Wümme), Germany, 27356
Withdrawn
Research Team
S
Sarah Berger, MD
CONTACT
P
Peter Ahnert, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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