Actively Recruiting
Study of QLS-111-FDC in Open-Angle Glaucoma or Ocular Hypertension
Led by Qlaris Bio, Inc. · Updated on 2026-04-03
60
Participants Needed
1
Research Sites
17 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Firecrest study is evaluating the intraocular pressure (IOP)-lowering effect, safety, and tolerability of Qlaris' preservative free \[PF\], fixed-dose combination \[FDC\] investigational product (IP) in subjects with open-angle glaucoma (OAG) or ocular hypertension (OHT).
CONDITIONS
Official Title
Study of QLS-111-FDC in Open-Angle Glaucoma or Ocular Hypertension
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Best corrected visual acuity (BCVA) of 1.0 logMAR (20/200) or better in each eye
- Diagnosis of mild to moderate open-angle glaucoma (OAG) or ocular hypertension (OHT) in at least one eye
- Intraocular pressure (IOP) of 19 mmHg or higher at 08:00 hour during qualification visits after run-in with preservative-free latanoprost
You will not qualify if you...
- History of active ocular disease other than mild to moderate OAG or OHT
- Prior use of any topical prostaglandin analogue (PGA) without a clinically meaningful response
- Noncompliance with current ocular anti-hypertensive medications or unwillingness to comply during the study
- Use of other topical ocular medications within 30 days prior to the study
- History of angle closure or narrow angle, significant ocular trauma, infection, uveitis, or intraocular surgery in either eye
- Central corneal thickness less than 470 µm or greater than 630 µm in either eye
- Clinically significant systemic or psychiatric disease, chronic kidney disease, or uncontrolled hypertension, hypotension, or diabetes
- Participation in any investigational study within 30 days prior to screening
- Females who are pregnant, nursing, or not using birth control
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Shettle Eye Research
Largo, Florida, United States, 33773
Actively Recruiting
Research Team
L
Lisa Brandano
CONTACT
L
Lauryl Hargreaves
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here