Actively Recruiting
A Pilot Study of Spatially Fractionated Radiation Therapy in Patients With Extra-Cranial Soft Tissue Metastases
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-03-30
26
Participants Needed
7
Research Sites
N/A
Total Duration
On this page
Sponsors
M
Memorial Sloan Kettering Cancer Center
Lead Sponsor
V
Varian Medical Systems
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are evaluating whether lattice radiation therapy (LRT) is an effective radiation treatment compared to standard stereotactic body radiation therapy (SBRT) for patients with metastatic solid tumors that have spread to soft tissue outside the brain. The study also examines how these radiation techniques affect immune cells' ability to attack tumor cells, called immune infiltration. Participants with metastatic solid tumors and measurable disease at two or more extracranial sites will receive palliative radiotherapy using external beam ionizing radiation following standard practice. If additional sites require treatment, standard SBRT may be used per guidelines. This is an interventional study conducted by Memorial Sloan Kettering Cancer Center. During the study, participants will be monitored for overall response rate at 12 weeks from baseline. Researchers will assess tumor response and immune effects. Participants will undergo clinical evaluations and follow study procedures, including radiation treatments and safety monitoring. The study started in July 2023 and will continue until July 2026.
CONDITIONS
Brief Title
A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with biopsy confirmed advanced or metastatic solid tumors including invasive ductal or lobular breast carcinoma, non-small cell lung cancer, gastrointestinal squamous cell or adenocarcinomas, pancreatic cancer, bladder cancer, renal cell carcinoma, melanoma, and soft tissue sarcoma
- Planned for palliative radiation therapy to at least one extracranial metastatic site measuring at least 5 cm
- Age 18 years or older
- ECOG Performance Status of 0 or 1
You will not qualify if you...
- Pregnant or breastfeeding patients
- Prior radiation therapy to the metastatic sites planned for treatment
- Medical conditions such as uncontrolled infection, uncontrolled diabetes, or connective tissue diseases that pose excessive risk
- Currently active metastatic second malignancy
- Use of oral or parental corticosteroids at supraphysiological doses
- Receiving anti-neoplastic treatment during radiation therapy or within 3 days before and after
- Unwilling or unable to participate in required study procedures
- Unable to understand study purpose, risks, and provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration depends on radiation therapy schedule
Participants receive palliative radiation therapy using external beam ionizing radiation to treat metastatic solid tumors.
1 or more visits depending on treatment plan
Trial Site Locations
Total: 7 locations
1
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen (Limited protocol activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Suffolk- Commack (Limited Protocol Activities)
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (All Protocol Activities)
Harrison, New York, United States, 10604
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, United States, 10065
Actively Recruiting
7
Memorial Sloan Kettering Nassau (Limited protocol activities)
Rockville Centre, New York, United States, 11553
Actively Recruiting
Research Team
A
Atif Khan, MD
C
Christopher Barker, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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