Actively Recruiting
A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-03-30
26
Participants Needed
7
Research Sites
156 weeks
Total Duration
On this page
Sponsors
M
Memorial Sloan Kettering Cancer Center
Lead Sponsor
V
Varian Medical Systems
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to find out whether lattice radiation therapy (LRT) is an effective radiation therapy technique when compared to standard stereotactic body radiation therapy (SBRT). The study will also study how the different radiation therapy techniques (LRT and SBRT) affect how many immune cells are able to attack and kill tumor cells (immune infiltration).
CONDITIONS
Official Title
A Study of Radiation Therapy to Treat Solid Tumor Cancer That Has Spread to Soft Tissue
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with biopsy confirmed advanced or metastatic solid tumors of the following types: invasive ductal or lobular breast carcinoma (all subtypes), non-small cell lung cancer (all subtypes), gastrointestinal squamous cell or adenocarcinomas (including pancreatic cancer), bladder cancer, renal cell carcinoma, melanoma, and soft tissue sarcoma (all subtypes), requiring palliative radiation therapy to at least one extracranial metastatic site measuring at least 5 cm in a single axis
- Age 18 years or older
- ECOG Performance Status of 0 or 1
You will not qualify if you...
- Pregnant or breastfeeding patients
- Prior radiation therapy to the metastatic sites planned for treatment
- Uncontrolled medical conditions such as infection (including HIV), diabetes mellitus, or connective tissue diseases that pose high risk
- Patients with an active metastatic second malignancy
- Use of oral or parenteral corticosteroids above physiological doses during radiation treatment
- Concurrent anti-cancer treatments during radiation therapy and within 3 days before and after treatment
- Inability or unwillingness to participate in required study evaluations and procedures
- Inability to understand study purpose and provide informed consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 7 locations
1
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen (Limited protocol activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Suffolk- Commack (Limited Protocol Activities)
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (All Protocol Activities)
Harrison, New York, United States, 10604
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, United States, 10065
Actively Recruiting
7
Memorial Sloan Kettering Nassau (Limited protocol activities)
Rockville Centre, New York, United States, 11553
Actively Recruiting
Research Team
A
Atif Khan, MD
CONTACT
C
Christopher Barker, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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