Actively Recruiting
Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC
Led by Revolution Medicines, Inc. · Updated on 2026-03-09
616
Participants Needed
89
Research Sites
254 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this platform study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of novel RAS(ON) inhibitors as a monotherapy or combined with Standard(s) of Care (SOC) or with each other. The first four subprotocols include the following: Subprotocol A: RMC-6291 +/- RMC-6236 + SOC Subprotocol B: RMC-6236 + SOC Subprotocol C: RMC-9805 +/- RMC-6236 + SOC Subprotocol D: RMC-9805
CONDITIONS
Official Title
Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- ECOG performance status 0 to 1
- Adequate organ function as defined by the study
- Prior standard therapy appropriate for tumor type and stage
- Pathologically confirmed locally advanced or metastatic KRAS G12C-mutated solid tumor (Subprotocol A)
- Pathologically confirmed locally advanced or metastatic RAS-mutated NSCLC (Subprotocol B)
- Pathologically confirmed locally advanced or metastatic RAS G12D-mutated NSCLC (Subprotocols C and D)
You will not qualify if you...
- Primary central nervous system tumors
- Impaired gastrointestinal function affecting absorption of study drugs
- Major surgery within 28 days before first dose
- Active or history of interstitial lung disease or pneumonitis requiring steroids
- Other inclusion/exclusion criteria may apply
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 89 locations
1
Banner MD Anderson Cancer Center
Gilbert, Arizona, United States, 85234
Actively Recruiting
2
City of Hope - Duarte
Duarte, California, United States, 91010
Actively Recruiting
3
City of Hope - Lennar
Irvine, California, United States, 92618
Actively Recruiting
4
UC Davis, Davis Comprehensive Cancer Center
Sacramento, California, United States, 95817
Actively Recruiting
5
University of California, San Diego Moores Cancer Center
San Diego, California, United States, 92037
Actively Recruiting
6
UCSF Medical Center - Mission Bay
San Francisco, California, United States, 94158
Actively Recruiting
7
Stanford University - Stanford Cancer Institute
Stanford, California, United States, 94305
Actively Recruiting
8
Georgetown University Medical Center
Washington D.C., District of Columbia, United States, 20007
Actively Recruiting
9
Boca Raton Clinical Research Associates
Plantation, Florida, United States, 33322
Actively Recruiting
10
Cancer Specialists of North Florida
Saint Augustine, Florida, United States, 32086
Actively Recruiting
11
H Lee Moffitt Cancer Center and Research Institute
Tampa, Florida, United States, 33612
Actively Recruiting
12
Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
13
Henry Ford Cancer - Detroit (Brigitte Harris Cancer Pavilion)
Detroit, Michigan, United States, 48202
Actively Recruiting
14
Intermountain Health - St. Vincent Frontier Cancer Center
Billings, Montana, United States, 59102
Actively Recruiting
15
Nebraska Cancer Specialist
Grand Island, Nebraska, United States, 68803
Actively Recruiting
16
New York University Langone Health
New York, New York, United States, 10016
Actively Recruiting
17
Icahn School of Medicine at Mount Sinai
New York, New York, United States, 10029
Actively Recruiting
18
Columbia University Medical Center
New York, New York, United States, 10032
Actively Recruiting
19
Clinical Research Alliance
Westbury, New York, United States, 11590
Actively Recruiting
20
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States, 44106
Actively Recruiting
21
UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania, United States, 15232
Actively Recruiting
22
Baptist Medical Center
Memphis, Tennessee, United States, 38120
Actively Recruiting
23
Tennessee Oncology
Nashville, Tennessee, United States, 37203
Actively Recruiting
24
The University of Texas MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
25
NEXT Oncology Dallas
Irving, Texas, United States, 75039
Actively Recruiting
26
NEXT Oncology Virginia
Fairfax, Virginia, United States, 22031
Actively Recruiting
27
Chris O'Brien Lifehouse Hosptial
Camperdown, New South Wales, Australia, 2050
Actively Recruiting
28
Liverpool Hospital
Liverpool, New South Wales, Australia, 2170
Actively Recruiting
29
Royal North Shore Hospital
St Leonards, New South Wales, Australia, 2065
Actively Recruiting
30
Monash Health
Clayton, Victoria, Australia, 3168
Actively Recruiting
31
Linear Clinical Research
Nedlands, Western Australia, Australia, 6009
Actively Recruiting
32
Rigshospitalet
Copenhagen, Denmark, 2100
Actively Recruiting
33
Odense University Hospital, Department of Oncology
Odense, Denmark, 5000
Actively Recruiting
34
Hospices Civils de Lyon - Hôpital Louis Pradel
Bron, Auvergne-Rhône-Alpes, France, 69500
Actively Recruiting
35
Centre Georges François Leclerc
Dijon, Bourgogne-Franche-Comté, France, 21079
Actively Recruiting
36
CHU de Lille Institut Cœur Poumon
Lille, Hauts-de-France, France, 59037
Actively Recruiting
37
CHU de Nantes
Nantes, Hauts-de-France, France, 44093
Actively Recruiting
38
EDOG - Institut Bergonié
Bordeaux, New Aquitaine, France, 33000
Actively Recruiting
39
Institut de Cancerologie de Ouest (ICO) - Angers
Angers, France, 49055
Actively Recruiting
40
Ambroise-Paré Hospital
Boulogne, France, 92104
Actively Recruiting
41
Centre François Baclesse
Caen, France, 14076
Actively Recruiting
42
Hôpital Cochin
Paris, France, 75014
Actively Recruiting
43
Hopital Tenon - AP-HP
Paris, France, 75020
Actively Recruiting
44
Hopital Foch
Suresnes, France, 92150
Actively Recruiting
45
Oncopole Claudius Regaud
Toulouse, France, 31059
Actively Recruiting
46
Institut Gustave Roussy
Villejuif, France, 94805
Actively Recruiting
47
Institut Curie
Paris, Île-de-France Region, France, 75005
Actively Recruiting
48
Charite-Universitaetsmedizin Berlin - Campus Charite Mitte
Berlin, Germany, 12203
Actively Recruiting
49
Uniklinik Köln
Cologne, Germany, 50937
Actively Recruiting
50
Universitätsklinikum Carl Gustav Carus an der TU Dresden
Dresden, Germany, 01307
Actively Recruiting
51
Universitätsklinikum Frankfurt
Frankfurt am Main, Germany, 60590
Actively Recruiting
52
Thoraxklinik Heidelberg gGmbH - Universitätsklinikum Heidelberg
Heidelberg, Germany, 69126
Actively Recruiting
53
Lungenfachklinik Immenhausen
Immenhausen, Germany, 34376
Actively Recruiting
54
Krankenhaus Bethanien Moers
Moers, Germany, 47441
Actively Recruiting
55
Henry Dunant Hospital Center
Athens, Greece, 115 26
Actively Recruiting
56
Thoracic General Hospital of Athens "I SOTIRIA"
Athens, Greece, 11527
Actively Recruiting
57
Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST S.r.l
Meldola, Emilia-Romagna, Italy, 47014
Actively Recruiting
58
Fondazione IRCCS Istituto Nazionale dei tumori
Milan, Italy, 20133
Actively Recruiting
59
ASST Grande Ospedale Metropolitano Niguarda
Milan, Italy, 20162
Actively Recruiting
60
A.O.U. San Luigi Gonzaga-Orbassano - SCDU Oncologia Medica
Orbassano, Italy, 10043
Actively Recruiting
61
Ospedale Santa Maria Delle Croci
Ravenna, Italy, 48121
Actively Recruiting
62
IRCCS Instituto Nazionale tumori Ragina Elena
Rome, Italy, 00144
Actively Recruiting
63
Fondazione Policlinico Universitario A Gemelli-Rome
Rome, Italy, 00168
Actively Recruiting
64
The Netherlands Cancer Institute (NKI)
Amsterdam, Netherlands, 1066
Actively Recruiting
65
University Medical Centre Groningen
Groningen, Netherlands, 9713
Actively Recruiting
66
Leiden University Medical Center
Leiden, Netherlands, 2333 ZA
Actively Recruiting
67
University Medical Center Utrecht
Utrecht, Netherlands, 3584
Actively Recruiting
68
Samsung Medical Center
Seoul, Gangnam-gu, South Korea, 06351
Actively Recruiting
69
National Cancer Center
Goyang-si, Gyeonggi-do, South Korea, 10408
Actively Recruiting
70
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggido, South Korea, 13620
Actively Recruiting
71
Seoul St. Mary's Hospital, The Catholic University of Korea
Seoul, Seocho-gu, South Korea, 06591
Actively Recruiting
72
Severance Hospital
Seoul, Seodaemun-Gu, South Korea, 03722
Actively Recruiting
73
Hospital Clinico San Carlos
Madrid, Madrid, Spain, 28040
Actively Recruiting
74
Hospital Universitario 12 de Octubre
Madrid, Madrid, Spain, 28041
Actively Recruiting
75
Clinica Universidad de Navarra
Pamplona, Navarre, Spain, 31008
Actively Recruiting
76
Hospital Universitari i Politecnic La Fe de Valencia
Valencia, Valencia, Spain, 46026
Actively Recruiting
77
Complejo Hospitalario Universitario A Coruña
A Coruña, Spain, 15006
Actively Recruiting
78
Hospital Universitari Vall D' Hebron
Barcelona, Spain, 08035
Actively Recruiting
79
ICO Badalona - H.U. Germans Trias i Pujol
Barcelona, Spain, 08916
Actively Recruiting
80
Hospital Universitario Ramon y Cajal
Madrid, Spain, 28034
Actively Recruiting
81
Hospital Universitario Fundacion Jimenez Diaz
Madrid, Spain, 28040
Actively Recruiting
82
Hospital Regional Universitario de Malaga - Hospital Civil
Málaga, Spain, 29011
Actively Recruiting
83
Hospital Universitario Virgen del Rocio - PPDS
Seville, Spain, 41014
Actively Recruiting
84
Fundacion Instituto Valenciano de Oncologia
Valencia, Spain, 46009
Actively Recruiting
85
Taipei Municipal Wanfang Hospital
Taipei, Wenshan Dist, Taiwan, 116
Actively Recruiting
86
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, Taiwan, 807
Actively Recruiting
87
Taichung Veterans General Hospital
Taichung, Taiwan, 40705
Actively Recruiting
88
Chi Mei Hospital, Liouying
Tainan, Taiwan, 73657
Actively Recruiting
89
Taipei Veterans General Hospital
Taipei, Taiwan, 11217
Actively Recruiting
Research Team
R
Revolution Medicines
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here