Actively Recruiting
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
Led by Revolution Medicines, Inc. · Updated on 2026-04-01
1130
Participants Needed
32
Research Sites
163 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this platform study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of novel RAS(ON) inhibitors combined with Standard(s) of Care (SOC) or with novel agents. The current subprotocols include the following: Subprotocol A: RMC-6236 + 5-fluorouracil-based regimens Subprotocol B: RMC-6236 + cetuximab with or without mFOLFOX6 Subprotocol C: RMC-6236 + gemcitabine + nab-paclitaxel Subprotocol D: RMC-9805 with or without RMC-6236 + 5-fluorouracil-based regimens Subprotocol E: RMC-9805 with or without RMC-6236 + cetuximab with or without mFOLFOX6 Subprotocol F: RMC-9805 with or without RMC-6236 + gemcitabine + nab-paclitaxel
CONDITIONS
Official Title
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- ECOG performance status of 0 to 1
- Adequate organ function as defined by the study
- Pathologically or cytologically confirmed pancreatic carcinoma or poorly differentiated pancreatic carcinoma with metastatic disease or RAS-mutated colorectal adenocarcinoma with unresectable or metastatic disease (for Subprotocols A, B, and C)
- Presence of RAS G12D mutation (for Subprotocols D, E, and F)
You will not qualify if you...
- Primary central nervous system tumors
- Impaired gastrointestinal function that may significantly affect absorption of study drugs
- Major surgery within 28 days before the first dose
- Other inclusion/exclusion criteria may apply
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 32 locations
1
Ironwood Cancer and Research Centers
Chandler, Arizona, United States, 85224
Actively Recruiting
2
Mayo Clinic Hospital
Phoenix, Arizona, United States, 85054
Actively Recruiting
3
HonorHealth Research Institute
Scottsdale, Arizona, United States, 85258
Actively Recruiting
4
UC San Diego Moores Cancer Center
La Jolla, California, United States, 92093
Actively Recruiting
5
Cedars-Sinai Cancer at Cedars-Sinai Medical Center
Los Angeles, California, United States, 90048
Actively Recruiting
6
UCLA Hematology/Oncology- Santa Monica
Los Angeles, California, United States, 90404
Actively Recruiting
7
University of Colorado Hospital-Anschutz Cancer Pavilion
Aurora, Colorado, United States, 88045
Actively Recruiting
8
Yale-New Haven Hospital-Yale Cancer Center
New Haven, Connecticut, United States, 06520
Actively Recruiting
9
Mayo Clinic Cancer Center
Jacksonville, Florida, United States, 32224
Actively Recruiting
10
Moffitt Cancer Center
Tampa, Florida, United States, 33612
Actively Recruiting
11
The University of Kansas Clinical Research Center
Westwood, Kansas, United States, 66205
Actively Recruiting
12
The Sidney Kimmel Comprehensive Cancer Center at John Hopkins
Baltimore, Maryland, United States, 21287
Actively Recruiting
13
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
14
Dana Farber Cancer Institute
Boston, Massachusetts, United States, 02215
Actively Recruiting
15
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
16
Nebraska Cancer Specialists
Omaha, Nebraska, United States, 68130
Actively Recruiting
17
University of Nebraska Medical Center
Omaha, Nebraska, United States, 68198
Actively Recruiting
18
Atlantic Health System
Morristown, New Jersey, United States, 07960
Actively Recruiting
19
Northwell Health / RJ Zuckerberg Cancer Center
Lake Success, New York, United States, 11042
Actively Recruiting
20
Columbia University Medical Center
New York, New York, United States, 10032
Actively Recruiting
21
Memorial Sloan Kettering Cancer Center Main Campus
New York, New York, United States, 10065
Actively Recruiting
22
Duke University Medical Center
Durham, North Carolina, United States, 27710
Actively Recruiting
23
University of Cincinnati Medical Center
Cincinnati, Ohio, United States, 45267
Actively Recruiting
24
Stephenson Cancer Center
Oklahoma City, Oklahoma, United States, 73104
Actively Recruiting
25
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
26
SCRI Oncology Partners
Nashville, Tennessee, United States, 37203
Actively Recruiting
27
Baylor College of Medicine
Houston, Texas, United States, 77030
Actively Recruiting
28
The University of Texas MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
29
NEXT Oncology Dallas
Irving, Texas, United States, 75039
Actively Recruiting
30
Huntsman Cancer Institute, University of Utah
Salt Lake City, Utah, United States, 84112
Actively Recruiting
31
Virginia Cancer Specialists
Fairfax, Virginia, United States, 22314
Actively Recruiting
32
Fred Hutchinson Cancer Center
Seattle, Washington, United States, 98109
Actively Recruiting
Research Team
R
Revolution Medicines
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
6
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