Actively Recruiting
Study on Recurrent Breast Cancer and Repeated Radiation Therapy
Led by Turku University Hospital · Updated on 2026-03-09
60
Participants Needed
2
Research Sites
317 weeks
Total Duration
On this page
Sponsors
T
Turku University Hospital
Lead Sponsor
H
Helsinki University Central Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study explores whether recurrent breast cancer can be safely treated with breast-conserving surgery and repeated radiation therapy in cases where patients have previously undergone radiation. Traditionally, recurrent breast cancer has been treated by removing the entire breast. However, recent research has shown that in certain situations, it may be possible to preserve the breast. The study will collect data on the safety of this treatment approach and its effects on patients. The treatment follows standard breast cancer care practices, involving 30 patients from Helsinki and Turku University Hospitals. Patients are carefully selected based on specific criteria, such as tumor size, localization, and prior treatment history. Special attention is given to the planning of radiation therapy and surgical techniques. The goal is to develop new treatment strategies that allow breast preservation even in cases of recurrent breast cancer, providing patients with high-quality and individualized care.
CONDITIONS
Official Title
Study on Recurrent Breast Cancer and Repeated Radiation Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed breast cancer or tumor in the breast with maximum diameter of 3 cm after previous breast-conserving surgery (including invasive cancer or carcinoma in situ).
- Only local recurrence with no suspicion of metastases outside the breast (N0M0 staging).
- At least 3 years have passed since prior radiation therapy completion.
- New breast cancer can be treated with repeat breast-conserving surgery without needing tissue transfer from opposite breast areas.
- Patient is at least 55 years old at the time of surgery.
- Patient is willing and capable to provide informed consent and participate in the study.
You will not qualify if you...
- A booster dose was given during previous radiation therapy.
- Preoperative assessment suggests multifocal breast cancer or tumor area exceeding 3 cm.
- Planned radiation therapy cannot be given due to factors like shoulder stiffness, pacemaker in radiation field, or skin conditions such as scleroderma.
- Patient is unable or unwilling to provide informed consent.
- Presence of metastases outside the breast (axillary or distant).
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Helsinki University Hospital
Helsinki, Finland
Actively Recruiting
2
Turku University Hospital
Turku, Finland
Actively Recruiting
Research Team
A
Anselm Tamminen, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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