Phase III Study Comparing Very Low Dose Radiation to Standard Radiation for Treating Indolent B-Cell Lymphomas

What this Trial Is About

Researchers are evaluating whether a very low dose of radiation therapy VLDRT is an effective treatment for people with follicular lymphoma FL or marginal zone lymphoma MZL. This study compares VLDRT to the standard dose of radiation therapy to see if the low dose can control cancer in affected areas and prevent new lymphoma spots while causing fewer side effects. Radiation therapy uses intense energy beams to kill cancer cells, and standard doses may cause both short- and long-term side effects. Researchers aim to find out if using less radiation can reduce these side effects while still working against the cancer. Participants will be randomly assigned to receive either the very low dose radiation therapy of 4 Gy given in 1-2 daily treatments or the standard radiation dose of 24 Gy given in 12 treatments over consecutive business days. Both treatments target all initially involved cancer sites. About 12 weeks after treatment, participants will have repeat imaging and clinical evaluations to assess the cancers response to therapy. During the study, participants will undergo imaging and clinical assessments at 12 weeks post-treatment to monitor cancer progression and response. The primary outcome measured is progression-free survival at 2 years, with radiographic response also evaluated at 6 months. The total duration of participation varies, with ongoing monitoring to compare the effectiveness and side effects of the two radiation dosing strategies. This study is led by Memorial Sloan Kettering Cancer Center and has no masking or blinding.

A Study of Reduced Dose Radiation Therapy for People With B-Cell Lymphomas