Actively Recruiting
Study of the Relationship Between Clinical, Imaging and Biological Data in Patients With Squamous Cell Carcinoma of the Tongue
Led by Centre Hospitalier Universitaire, Amiens · Updated on 2024-06-10
60
Participants Needed
1
Research Sites
113 weeks
Total Duration
On this page
Sponsors
C
Centre Hospitalier Universitaire, Amiens
Lead Sponsor
G
Groupe Hospitalier Pitie-Salpetriere
Collaborating Sponsor
AI-Summary
What this Trial Is About
Squamous cell carcinoma (SCC) could be a very aggressive cancer and has a bad prognosis if not detected early and thus is associated with high mortality. The development of simple and reliable biomarkers for the early detection of SCC is one of the solutions to better diagnose, treat these tumors, evaluate and monitor treatments, and hence reduce mortality. In a previous work, the investigators demonstrated the ability of Proton Magnetic resonance spectroscopy (1H-MRS) to non-invasively assess spectroscopic and metabolic profiles of tongue tissue in healthy subjects. In the present work, the investigators challenge the use of in-vivo 1H-MRS as a potential method for non-invasive metabolic monitoring of patients with squamous cell carcinoma of the tongue undergoing therapy. Thus the main objective is to study the spectroscopic and metabolic differences, e.g. including variation in the metabolite TMA-Cho (trimethylamine-choline), of tongue tissue between healthy subjects and in patients with squamous cell carcinoma of the tongue, before and after surgery.
CONDITIONS
Official Title
Study of the Relationship Between Clinical, Imaging and Biological Data in Patients With Squamous Cell Carcinoma of the Tongue
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients treated for histologically confirmed squamous cell carcinoma of the tongue
- Patients not yet treated surgically or by neoadjuvant therapy
- Tumor size of at least 15 mm in the longest dimension
- No contraindication to MRI
- Age 18 years or older
- Provided free and informed written consent
- Benefiting from a social security system
- Healthy volunteers without history of upper aerodigestive tract cancer
- Healthy volunteers with no contraindication to MRI
- Healthy volunteers aged 18 years or older
- Healthy volunteers provided free and informed written consent
- Healthy volunteers benefiting from a social security system
You will not qualify if you...
- Patients with a tongue tumor smaller than 15 mm in longest dimension
- Patients or volunteers with other types or locations of cancer
- Subjects with contraindications to MRI
- Subjects under 18 years old
- Pregnant or breastfeeding women
- Persons under guardianship, curatorship, judicial protection, or deprived of liberty
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Trial Site Locations
Total: 1 location
1
CHU Amiens
Amiens, France, 80480
Actively Recruiting
Research Team
J
Jean-Marc Constans, Pr
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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