Actively Recruiting
A Study of Response Adapted Ultra Low Dose 4 Gy Radiation for Definitive Therapy of Marginal Zone Lymphoma
Led by M.D. Anderson Cancer Center · Updated on 2026-01-09
50
Participants Needed
1
Research Sites
231 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To learn if response-adapted, ultra-low dose radiation therapy can help to control MZL. This means participates first receive lower does of radiation therapy and then, based on how the disease responds, may receive higher doses after that.
CONDITIONS
Official Title
A Study of Response Adapted Ultra Low Dose 4 Gy Radiation for Definitive Therapy of Marginal Zone Lymphoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients 18 years or older
- Diagnosed with stage I-II marginal zone lymphoma or low grade B cell lymphoma favoring marginal zone lymphoma
- No planned systemic therapy before first follow-up after radiation
- If previously treated with other modalities, must have measurable residual disease
- Prior systemic therapy allowed if before most recent disease assessment
- Prior antibiotics or topical therapies for lymphoma allowed if before most recent disease assessment
- For gastric MALT lymphoma, required Helicobacter pylori testing on biopsy specimen
- Female patients of childbearing potential must have negative pregnancy test within 1 week of radiation
- Agreement to use adequate contraception for women of childbearing potential and men during radiation and for 4 months after
- Ability to understand and sign informed consent
- Patients with bulky tumors (>7.5 cm) allowed
- Patients with prior or concurrent malignancies that do not interfere with study assessments allowed
You will not qualify if you...
- Psychiatric illness or social situations limiting study compliance
- Pregnant women
- Lymphoma diagnoses other than marginal zone lymphoma
- History of radiation to the treated site exceeding safe tolerance levels
- Active scleroderma under treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
MD Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
J
Jillian Gunther, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here