Actively Recruiting
A Study of Response to Standard Treatment Before Surgery in People With Rectal Cancer
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-03-18
30
Participants Needed
6
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of the study is to learn more about how the body responds to standard treatment (chemoradiation and chemotherapy). The study will use the results of testing down on participants' blook, tissue, and scans to learn more about how people with rectal cancer respond to chemoradiation and chemotherapy treatment and if it is useful for predicting whether a person's cancer get better, gets worse, or stats the same after treatment.
CONDITIONS
Official Title
A Study of Response to Standard Treatment Before Surgery in People With Rectal Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older on day of signing informed consent.
- Histologically confirmed invasive adenocarcinoma of the rectum without mismatch repair deficiency or Her2 amplification.
- Eligible for and planning to start standard chemoradiation with induction fluoropyrimidine (capecitabine or 5-FU).
- Planned consolidative chemotherapy with CAPEOX, FOLFOX, or FOLIRINOX.
- Women of childbearing potential must have a negative pregnancy test and agree to use effective contraception during treatment.
You will not qualify if you...
- Prior or concurrent malignancy that could interfere with study safety or efficacy assessments.
- Previous external beam radiation therapy to the pelvis or prostate brachytherapy seed implantation.
- Pregnant or breastfeeding women.
- Men or women not using effective contraception.
- Contraindication to MR imaging.
- Use of blood thinners that prevent endoluminal tumor biopsies.
AI-Screening
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Trial Site Locations
Total: 6 locations
1
Memorial Sloan Kettering Monmouth (Limited protocol activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
2
Memorial Sloan Kettering Bergen (Limited protocol activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
3
Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)
Commack, New York, United States, 11725
Actively Recruiting
4
Memorial Sloan Kettering Westchester (Limited protocol activities)
Harrison, New York, United States, 10604
Actively Recruiting
5
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, United States, 10065
Actively Recruiting
6
Memorial Sloan Kettering Nassau (Limited protocol activities)
Rockville Centre, New York, United States, 11553
Actively Recruiting
Research Team
P
Paul Romesser, MD
CONTACT
A
Andrea Cercek, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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