Actively Recruiting
Study of the Role of the Induced Membrane in the Reconstruction of Bone Loss in the Limbs
Led by Direction Centrale du Service de Santé des Armées · Updated on 2022-12-21
80
Participants Needed
2
Research Sites
335 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Masquelet's induced membrane technique is a two-stage reconstructive surgery for severe bone fractures commonly used by military orthopedists. The particularity of this technique relies on the synthesis of a biological membrane induced by the transient implantation of a surgical cement (= 1st stage surgery). The presence of the induced membrane in the reconstruction space defines a microenvironment or "biological chamber" favourable to osteogenesis, positively influencing the repair of the lesion after implantation of an autologous bone graft (= 2nd stage of surgery). In view of the excellent clinical results obtained with this procedure, the Masquelet technique has gradually become a reference treatment in the field of orthopedic and trauma surgery. However, orthopedic surgeons sometimes observe failures in bone consolidation. To our knowledge, the role played by induced membrane in these therapeutic failures has never been studied.
CONDITIONS
Official Title
Study of the Role of the Induced Membrane in the Reconstruction of Bone Loss in the Limbs
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Patient with traumatic bone loss
- Patient eligible for the induced membrane technique
You will not qualify if you...
- Patients with post-tumor bone loss
- Patients who are immunocompromised or under immunosuppressive treatment
- Patients with chronic inflammatory disease such as diabetes or inflammatory bowel disease
- Patients with collagenosis
- Patients with a contraindication to sampling
- Pregnant or breastfeeding women
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Hôpital d'Instruction des Armées Percy
Clamart, France, 92140
Actively Recruiting
2
Hôpital d'Instruction des Armées Bégin
Saint-Mandé, France, 94160
Actively Recruiting
Research Team
M
Marjorie DURAND, PhD
CONTACT
L
Laurent MATHIEU, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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