Actively Recruiting
Study and Role of Inflammasome in Platelet Activation During Bacterial And/or Viral Sepsis
Led by Centre Hospitalier Universitaire de la Guadeloupe · Updated on 2024-10-24
171
Participants Needed
1
Research Sites
204 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
: Sepsis, now defined as life-threatening organ dysfunction due to a dysregulated host response to infection, is an important global health problem representing about a fifth of all global deaths. It can be associated, in some cases, with multiple organ failure and cytokine storm. The main objective of this study is to estimate and to compare the activation rate of the Nucleotide-binding domain Leucine Rich repeat containing Protein 3 (NLRP3) inflammasome in platelets between five groups of patients suffering from bacterial and/or viral sepsis, with different severity levels according to Sequential Organ Failure Assessment (SOFA) score to precise the platelets' implication in this cytokine storm.
CONDITIONS
Official Title
Study and Role of Inflammasome in Platelet Activation During Bacterial And/or Viral Sepsis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients must be older than 18 years at the time of inclusion
- Patients or their legal representatives must accept participation
- Patients in groups 1, 2, 3, and 5 must have confirmed sepsis by microbiological tests
- Patients in group 4 must be non-infected
You will not qualify if you...
- Refusal to participate by the patient or their legal representative
- Patients under legal safeguard measures
- Patients younger than 18 years at inclusion
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Centre Hospitalier Universitaire de la Guadeloup
Les Abymes, Guadeloupe, Guadeloupe, 97139
Actively Recruiting
Research Team
F
Frédéric MARTINO, Doctor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
5
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