Actively Recruiting
Study on the Role and Mechanism of Plasma Exosome microRNAs in Cognitive Impairment in First-episode Schizophrenia
Led by Tianjin Anding Hospital · Updated on 2025-09-24
300
Participants Needed
1
Research Sites
163 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Schizophrenia is a severe mental illness characterised by positive symptoms, negative symptoms, and cognitive symptoms. In recent years, an increasing number of doctors and scholars have focused on cognitive symptoms; however, the mechanisms underlying cognitive impairment remain unclear. Recently, exosome research methods have provided new avenues for investigation. This study applies exosome research methods to first-episode, drug-naive schizophrenia patients to explore gene expression changes associated with cognitive impairment and gain a deeper understanding of the mechanisms underlying cognitive impairment. By integrating basic research with clinical findings, we aim to further investigate the molecular mechanisms underlying cognitive impairment in schizophrenia patients, identify potential intervention targets, and provide insights for future drug development.
CONDITIONS
Official Title
Study on the Role and Mechanism of Plasma Exosome microRNAs in Cognitive Impairment in First-episode Schizophrenia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy volunteers matched to the patient group on sex, age, and education level
- No family history of psychiatric disorders among first- or second-degree relatives (two generations)
- Ethnic Han Chinese
- Able and willing to provide written informed consent
You will not qualify if you...
- Any serious physical illness, including uncontrolled hypertension, severe cardiovascular, cerebrovascular, pulmonary, thyroid, or metabolic disease, diabetes, epilepsy, or metabolic syndrome
- Current or past diagnosis of substance-induced psychotic disorder, delusional disorder, brief psychotic disorder, or mood disorder with psychotic features
- Pregnancy or breastfeeding
- Any condition that would interfere with the ability to give informed consent or complete study procedures
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Tianjin Anding Hospital
Tianjin, China
Actively Recruiting
Research Team
J
Jie Li, Doctor
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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