Actively Recruiting
Study Safety and Efficacy of Deep Brain Stimulation (DBS) and Cervical Deep Lymphoid-venous Anastomosis (LVA) in Alzheimer's Disease
Led by Chinese PLA General Hospital · Updated on 2025-07-30
98
Participants Needed
1
Research Sites
130 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
To investigate the safety of deep brain stimulation (DBS) and cervical deep lymphoid-venous anastomosis (LVA) in the treatment of severe Alzheimer's disease (AD); to investigate the effectiveness of DBS and LVA in the treatment of severe AD, i.e., effects of deep brain stimulation on cognitive function, emotion and life quality in patients with severe AD.
CONDITIONS
Official Title
Study Safety and Efficacy of Deep Brain Stimulation (DBS) and Cervical Deep Lymphoid-venous Anastomosis (LVA) in Alzheimer's Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosis of dementia according to National Institute on Aging-Alzheimer's Association criteria
- Clinical Dementia Rating (CDR) score of 3 points
- Ability to walk independently or with a walker/cane
- Adequate vision and hearing to participate in exams and treatment
- Voluntary participation with written informed consent from patient and legal guardian
You will not qualify if you...
- Abnormal brain structure such as tumor, stroke, hydrocephalus, or hemorrhage
- Other neurological disorders like multiple sclerosis, epilepsy, or Parkinson's disease
- Psychiatric disorders including anxiety, depression, affective disorders, or drug-induced psychosis
- Severe internal diseases or use of certain medications affecting respiratory, cardiovascular, or nervous systems
- Severe hearing or vision loss
- Life expectancy less than 2 years due to other medical conditions
- History of brain surgery
- Contraindications to MRI or brain stimulation devices
- Sensitive skin or eczema
- Familial Alzheimer's disease
- Other types of dementia such as vascular, Lewy body, frontotemporal, or infectious dementia
- Any condition the investigator considers unsuitable for participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Chinese PLA General Hospital
Beijing, China
Actively Recruiting
Research Team
Z
Zhiqi Mao, Ph.D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
3
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