Actively Recruiting
Myocardial Perfusion in Spontaneous Coronary Artery Dissection Using Stress Contrast Echocardiography
Led by Mayo Clinic · Updated on 2026-01-07
50
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
Sponsors
M
Mayo Clinic
Lead Sponsor
N
National Heart, Lung, and Blood Institute (NHLBI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Researchers are exploring how microvascular blood flow and blood pressure respond to stress in people with a history of spontaneous coronary artery dissection (SCAD). This observational study uses stress contrast echocardiography to fill existing knowledge gaps about heart function in these patients compared to healthy individuals. The study is sponsored by Mayo Clinic and involves both participants with SCAD and healthy volunteers. The main procedure studied is stress echocardiography with contrast, which evaluates heart function and blood flow changes under stress. Participants are grouped into those with SCAD history and healthy subjects with no significant medical issues. The study measures changes in microvascular function, blood pressure, and heart rate immediately before and after the stress echocardiography. Participants will undergo baseline assessments followed by the stress echocardiography test with contrast. Researchers will monitor changes in heart performance and vital signs during the procedure. The study aims to understand the differences in cardiovascular responses between SCAD patients and healthy individuals. Participation involves a single visit with focused heart imaging and monitoring, with no ongoing treatment or long-term follow-up described.
CONDITIONS
Brief Title
A Study of SCAD Using Stress Contrast Echocardiography
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult over 18 years old
- Patient has a history of spontaneous coronary artery dissection (SCAD) OR is healthy with no significant medical history
You will not qualify if you...
- Unable to give consent
- Allergic or had adverse reaction to dobutamine, Definity ultrasound agent, or atropine
- Known or suspected hypersensitivity to perflutren (cannot be given Definity)
- Pregnant
- Unable to interrupt breastfeeding
- Within 3 months of a heart attack
- Severe aortic stenosis
- Severe, uncontrolled hypertension (greater than 200/110 mmHg at baseline)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo stress echocardiography with contrast to assess heart function and blood flow response to stressors.
1 visit (in-person)
Duration - Immediately after diagnostic evaluation
Participants are observed following the diagnostic evaluation to monitor changes in microvascular function, blood pressure, and heart rate.
No additional visits required
Trial Site Locations
Total: 1 location
1
Mayo Clinic
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
P
Pamela Engrav
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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