Actively Recruiting
A Study of SHR-A2102 in Combination With Adebrelimab and SHR-8068 in Subjects With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Led by Shanghai Hengrui Pharmaceutical Co., Ltd. · Updated on 2024-11-12
124
Participants Needed
1
Research Sites
82 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a multicenter, open-label, dose-finding/efficacy-expanding Phase IB/II clinical trial to evaluate SHR-A2102 in combination with adebelimab in combination with SHR-8068 in patients with locally advanced or metastatic non-small cell lung cancer. The study consists of two phases: Phase IB to explore the safety/tolerability of SHR-A2102 in combination with adebelimab in combination with SHR-8068 in patients with locally advanced or metastatic non-small cell lung cancer; Phase II: To explore the efficacy of SHR-A2102 in combination with adebelimab in combination with SHR-8068 in patients with locally advanced or metastatic non-small cell lung cancer.
CONDITIONS
Official Title
A Study of SHR-A2102 in Combination With Adebrelimab and SHR-8068 in Subjects With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to give voluntary informed consent, understand the study, and willing to complete all test procedures
- Aged 18 to 70 years old
- Pathologically confirmed unresectable locally advanced or metastatic non-small cell lung cancer
- At least one measurable lesion according to RECIST v1.1 criteria
- ECOG performance status score of 0 or 1
You will not qualify if you...
- Presence of active or symptomatic brain metastases
- Previous diagnosis of any other malignancy
- Clinically symptomatic moderate to severe ascites
- Uncontrollable or moderate or above pleural effusion or pericardial effusion
- Received anti-tumor therapy within 4 weeks before starting study treatment
- Uncontrolled tumor-related pain
- Severe cardiovascular or cerebrovascular diseases
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Shanghai Chest Hospital
Shanghai, Shanghai Municipality, China, 200030
Actively Recruiting
Research Team
X
Xin Xu
CONTACT
Y
Yunfei Zhang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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