Actively Recruiting
Study of SIM0508 Alone and in Combination in Patients With Advanced Solid Tumors
Led by Jiangsu Simcere Pharmaceutical Co., Ltd. · Updated on 2025-01-07
130
Participants Needed
2
Research Sites
212 weeks
Total Duration
On this page
Sponsors
J
Jiangsu Simcere Pharmaceutical Co., Ltd.
Lead Sponsor
S
Shanghai Xianxiang Medical Technology Co., Ltd.
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a multicenter, open-label, first-in-human study to evaluate the safety,efficacy, and PK/PD characteristics of SIM0508 as a single agent and in combination with olaparib in participants with locally advanced/metastatic solid tumors.
CONDITIONS
Official Title
Study of SIM0508 Alone and in Combination in Patients With Advanced Solid Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Voluntary participation with signed informed consent
- Adults with confirmed ovarian, prostate, breast, or pancreatic cancer
- ECOG performance status of 0 or 1
- Expected survival of 12 weeks or more
You will not qualify if you...
- Active hepatitis B or C infection
- Known HIV infection or AIDS
- Unable to swallow study medication or have gastrointestinal conditions affecting drug absorption
- Unresolved toxicities from previous cancer treatments above Grade 1
- Pregnant, nursing, or women of childbearing potential without a recent negative pregnancy test and contraceptive agreement
- Male participants with female partners of reproductive potential who do not agree to use highly effective contraception
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality, China
Actively Recruiting
2
Chongqing Cancer Hospital
Chongqing, China
Actively Recruiting
Research Team
J
Juan Wen Wang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SEQUENTIAL
Primary Purpose
TREATMENT
Number of Arms
3
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