Actively Recruiting
A Study of SPY072 in Rheumatic Disease
Led by Spyre Therapeutics, Inc. · Updated on 2026-05-08
285
Participants Needed
64
Research Sites
136 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a multi-center, double-blind, placebo-controlled, Phase 2, proof-of-concept basket study with the goal of assessing the efficacy and safety of SPY072 compared to placebo in adults (aged ≥18 years) with rheumatic disease (RD).
CONDITIONS
Official Title
A Study of SPY072 in Rheumatic Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years and older
- For rheumatoid arthritis: moderate-to-severely active RA with 4 or more swollen joints and 4 or more tender joints at screening and Day 1
- Positive rheumatoid factor or anti-citrullinated peptide antibodies at screening, or radiology showing erosions consistent with RA
- Inadequate response to at least 1 conventional synthetic disease-modifying anti-rheumatic drug and/or up to 2 classes of biologic or targeted synthetic DMARDs
- For axial spondyloarthritis: moderate-to-severely active axSpA with BASDAI score of 4 or higher and back pain score of 4 or higher at screening and Day 1
- High-sensitivity C-reactive protein above normal at screening
- Inadequate response to 2 different NSAIDs at maximum tolerated dose for 4 weeks or intolerance to NSAIDs, and/or up to 2 classes of biologic or targeted synthetic DMARDs for at least 12 weeks
- For psoriatic arthritis: tender joint count of 3 or more and swollen joint count of 3 or more at screening and Day 1
- At least 1 active plaque psoriasis lesion or a history of psoriasis
- Inadequate response to at least 1 NSAID, at least 1 conventional synthetic DMARD, and/or up to 2 classes of biologic or targeted synthetic DMARDs
You will not qualify if you...
- Inadequate response to more than 2 classes of biologic or targeted synthetic DMARDs
- Presence of other autoimmune, rheumatologic, inflammatory diseases or pain-amplification syndromes that could affect the evaluation of SPY072 efficacy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 64 locations
1
Site 113
Avondale, Arizona, United States, 85392
Actively Recruiting
2
Site 118
Tucson, Arizona, United States, 85748
Actively Recruiting
3
Site 114
Chula Vista, California, United States, 91910
Actively Recruiting
4
Site 111
Covina, California, United States, 91722
Actively Recruiting
5
Site 108
Tujunga, California, United States, 91042
Actively Recruiting
6
Site 112
Upland, California, United States, 91786
Actively Recruiting
7
Site 107
Whittier, California, United States, 90602
Actively Recruiting
8
Site 115
Aventura, Florida, United States, 33180
Actively Recruiting
9
Site 109
Hialeah, Florida, United States, 33016
Actively Recruiting
10
Site 106
Ormond Beach, Florida, United States, 32174
Actively Recruiting
11
Site 110
Tampa, Florida, United States, 33614
Actively Recruiting
12
Site 116
Willowbrook, Illinois, United States, 60527
Actively Recruiting
13
Site 119
Rockville, Maryland, United States, 20850
Actively Recruiting
14
Site 104
Duncansville, Pennsylvania, United States, 16635
Actively Recruiting
15
Site 105
Corpus Christi, Texas, United States, 78404
Actively Recruiting
16
Site 120
Irving, Texas, United States, 75039
Actively Recruiting
17
Site 103
Tomball, Texas, United States, 77375
Actively Recruiting
18
Site 102
Tomball, Texas, United States, 77377
Actively Recruiting
19
Site 503
Lovech, Lovech, Bulgaria, 5500
Actively Recruiting
20
Site 502
Pleven, Pleven, Bulgaria, 5803
Actively Recruiting
21
Site 506
Plovdiv, Plovdiv, Bulgaria, 4000
Actively Recruiting
22
Site 505
Plovdiv, Plovdiv, Bulgaria, 4003
Actively Recruiting
23
Site 504
Varna, Varna, Bulgaria, 9000
Actively Recruiting
24
Site 706
Hlučín, Hlučín, Czechia, 748 01
Actively Recruiting
25
Site 702
Moravská Ostrava, Ostrava-město, Czechia, 702 00
Actively Recruiting
26
Site 704
Pardubice, Pardubice Region, Czechia, 530 02
Actively Recruiting
27
Site 705
Prague, Praha, Hlavní Mesto, Czechia, 130 00
Actively Recruiting
28
Site 703
Prague, Praha, Hlavní Mesto, Czechia, 140 00
Actively Recruiting
29
Site 701
Uherské Hradiště, Zlín, Czechia, 68601
Actively Recruiting
30
Site 303
Tbilisi, K'alak'i T'bilisi, Georgia, 0102
Actively Recruiting
31
Site 304
Tbilisi, K'alak'i T'bilisi, Georgia, 0112
Actively Recruiting
32
Site 301
Tbilisi, K'alak'i T'bilisi, Georgia, 0159
Actively Recruiting
33
Site 307
Tbilisi, K'alak'i T'bilisi, Georgia, 0172
Actively Recruiting
34
Site 305
Tbilisi, K'alak'i T'bilisi, Georgia, 0186
Actively Recruiting
35
Site 308
Batumi, Georgia, 6010
Actively Recruiting
36
Site 302
Kutaisi, Georgia, 4600
Actively Recruiting
37
Site 306
Tbilisi, Georgia, 0186
Actively Recruiting
38
Site 201
Chisinau, Moldova, MD-2025
Actively Recruiting
39
Site 202
Chisinau, Moldova, MD-2025
Actively Recruiting
40
Site 401
Krakow, Lesser Poland Voivodeship, Poland, 30-363
Actively Recruiting
41
Site 407
Nowa Sól, Lubusz Voivodeship, Poland, 67-100
Actively Recruiting
42
Site 404
Lodz, Lódzkie, Poland, 91-363
Actively Recruiting
43
Site 403
Warsaw, Masovian Voivodeship, Poland, 02-677
Actively Recruiting
44
Site 402
Opole, Opole Voivodeship, Poland, 45-819
Actively Recruiting
45
Site 406
Gdynia, Pomeranian Voivodeship, Poland, 81-384
Actively Recruiting
46
Site 405
Warszawa, Pomeranian Voivodeship, Poland, 00-874
Actively Recruiting
47
Site 408
Elblag, Warmian-Masurian Voivodeship, Poland, 82-300
Actively Recruiting
48
Site 602
A Coruña, A Coruña, Spain, 15006
Actively Recruiting
49
Site 604
Chiclana de la Frontera, Cadiz, Spain, 11139
Actively Recruiting
50
Site 601
Santander, Madrid, Spain, 39008
Actively Recruiting
51
Site 603
Seville, Sevilla, Spain, 41010
Actively Recruiting
52
Site 809
Chernihiv, Chernihiv Oblast, Ukraine, 14029
Actively Recruiting
53
Site 813
Kyiv, Kyiv Oblast, Ukraine, 02091
Actively Recruiting
54
Site 806
Kyiv, Kyiv Oblast, Ukraine, 03049
Actively Recruiting
55
Site 804
Kyiv, Kyiv Oblast, Ukraine, 04050
Actively Recruiting
56
Site 803
Kyiv, Kyiv Oblast, Ukraine, 2125
Actively Recruiting
57
Site 805
Kyiv, Kyiv Oblast, Ukraine, 4106
Actively Recruiting
58
Site 807
Lviv, Lviv Oblast, Ukraine, 79044
Actively Recruiting
59
Site 808
Ternopil, Ternopil Oblast, Ukraine, 46002
Actively Recruiting
60
Site 810
Ternopil, Ternopil Oblast, Ukraine, 46002
Actively Recruiting
61
Site 801
Vinnytsia, Vinnytsia Oblast, Ukraine, 21028
Actively Recruiting
62
Site 802
Vinnytsia, Vinnytsia Oblast, Ukraine, 21029
Actively Recruiting
63
Site 812
Vinnytsia, Vinnytska, Ukraine, 21000
Actively Recruiting
64
Site 811
Zhytomyr, Zhytomyr Oblast, Ukraine, 10002
Actively Recruiting
Research Team
S
SKYWAY-RD Trial Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
7
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here