Actively Recruiting
A Study of Stereotactic Radiosurgery (SRS) to Treat Pain in the Chest and/or Stomach Wall
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-01-20
18
Participants Needed
7
Research Sites
260 weeks
Total Duration
On this page
Sponsors
M
Memorial Sloan Kettering Cancer Center
Lead Sponsor
V
Varian Medical Systems
Collaborating Sponsor
AI-Summary
What this Trial Is About
The researchers are doing this study to find out whether stereotactic radiosurgery (SRS) is a safe, practical (feasible), and effective treatment for people with chronic TAWP. The researchers will test different doses of SRS to find the highest dose that causes few or mild side effects.
CONDITIONS
Official Title
A Study of Stereotactic Radiosurgery (SRS) to Treat Pain in the Chest and/or Stomach Wall
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients must have a documented history of chronic (63 3 months) thoracoabdominal wall pain attributable to 64 3 unilateral spinal levels confirmed by a diagnostic paravertebral nerve block or TENS if needed
- Patients must have thoracoabdominal wall pain not adequately relieved by conventional pharmacologic therapy with a pain score 63 4/10 while on treatment
- Karnofsky Performance Status (KPS) score 63 60%
- Age 18 years or older
You will not qualify if you...
- Life expectancy less than 6 months as predicted by the Adult Comorbidity Index
- Active autoimmune connective tissue disease
- Bilateral thoracoabdominal wall pain
- Preexisting pneumothorax
- Preexisting excessive pleural effusion extending more than 3 vertebral levels
- Systemic chemotherapy delivered or planned within +/- 5 days of stereotactic radiosurgery
- Unable to undergo diagnostic paravertebral nerve block
- Unable to undergo at least one of myelogram or spine MRI
- External beam treatment plans cannot safely deliver SRS dose to lesion according to dose constraints
- Abnormal blood counts: platelet count less than 75 K/b5L, hemoglobin less than 9 g/dl, or white blood cell count less than 3.5 K/b5l
- Abnormal coagulation profile: INR greater than 2.5 or APTT greater than 80 seconds
- Patients on anticoagulation medications that cannot be safely held as required for myelogram
- Allergy to local anesthetics
- Local infection at anesthetic injection site
- Severe spinal deformities causing anatomical distortion
- Severe respiratory disease requiring oxygen dependence
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
2
Memorial Sloan Kettering Monmouth (Limited Protocol Activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
3
Memorial Sloan Kettering Bergen (Limited Protocol Activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
4
Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)
Commack, New York, United States, 11725
Actively Recruiting
5
Memorial Sloan Kettering Westchester (Limited Protocol Activities)
Harrison, New York, United States, 10604
Actively Recruiting
6
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
7
Memorial Sloan Kettering Nassau (Limited Protocol Activities)
Uniondale, New York, United States, 11553
Actively Recruiting
Research Team
J
Josh Yamada, MD
CONTACT
A
Amitabh Gulati, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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