A Phase 1 Trial Testing Single-Session Stereotactic Radiosurgery for Chronic Chest and Stomach Wall Pain Dose Levels from 70 Gy to 90 Gy Evaluated for Safety and Effectiveness

What this Trial Is About

Researchers are evaluating stereotactic radiosurgery SRS as a treatment for people with chronic thoracoabdominal wall pain TAWP caused by disease affecting the parietal pleura or parietal peritoneum. The study aims to find out if SRS is safe, practical, and effective for relieving this pain. This is a Phase 1 trial focusing on testing different doses to identify the highest dose that causes only mild or few side effects. Participants will receive a single session of radiation therapy at one of three dose levels 70 Gy, 80 Gy, or 90 Gy. The radiation is delivered using image-guided SRS techniques targeting the dorsal spinal nerve. The study will test these doses to understand dose escalation safety. Patients are treated during a single treatment period. During the trial, participants will undergo diagnostic nerve blocks or TENS to confirm the pain source and assessments by pain specialists. Researchers will monitor side effects and safety over two years to see if the dose escalation can occur without causing unacceptable toxic effects. Patients pain levels and overall function will be tracked, and laboratory tests and imaging will support safety assessments throughout the study period.

A Study of Stereotactic Radiosurgery (SRS) to Treat Pain in the Chest and/or Stomach Wall