Actively Recruiting
A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients
Led by AstraZeneca · Updated on 2026-04-17
1018
Participants Needed
159
Research Sites
381 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a global, randomised, Phase III, multicentre, open-label study evaluating the efficacy, safety and the degree of added benefit of the Surovatamig (AZD0486) plus rituximab combination compared to Investigator's choice of 3 standard immunochemotherapy regimen, conducted in participants with untreated FL.
CONDITIONS
Official Title
A Study of Surovatamig (AZD0486) Plus Rituximab in Previously Untreated Follicular Lymphoma Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participant must be at least 18 years of age at the time of signing the informed consent form
- Histologically confirmed diagnosis of classic follicular lymphoma according to WHO 2022 classification
- ECOG performance status of 0 to 2
- No prior systemic lymphoma-directed therapy
- Need for systemic treatment meeting at least one GELF criterion
- FDG-avid and measurable disease
- Stage II to IV follicular lymphoma with FLIPI score of 2 to 5 (Phase III only)
- Adequate liver, blood, kidney, and heart function
You will not qualify if you...
- Follicular large B-cell lymphoma or suspicion of transformation to high-grade/aggressive lymphoma
- Contraindication to BR, R-CVP, or R-CHOP treatments
- Current or past central nervous system lymphoma
- Clinically relevant CNS medical condition requiring treatment in the last year or interfering with safety evaluation
- More than 5000 circulating lymphoma cells
- Active or uncontrolled infection requiring systemic therapy, including EBV or recent COVID-19 without full recovery and negative tests
- History of hemophagocytic lymphohistiocytosis/macrophage activation syndrome
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 159 locations
1
Research Site
Anchorage, Alaska, United States, 99508
Not Yet Recruiting
2
Research Site
Phoenix, Arizona, United States, 85054
Not Yet Recruiting
3
Research Site
Clovis, California, United States, 93611
Not Yet Recruiting
4
Research Site
Los Alamitos, California, United States, 90720
Not Yet Recruiting
5
Research Site
San Diego, California, United States, 92121
Not Yet Recruiting
6
Research Site
Santa Monica, California, United States, 90404
Not Yet Recruiting
7
Research Site
Aurora, Colorado, United States, 80045
Withdrawn
8
Research Site
New Haven, Connecticut, United States, 06510
Not Yet Recruiting
9
Research Site
Jacksonville, Florida, United States, 32224
Not Yet Recruiting
10
Research Site
Atlanta, Georgia, United States, 30322
Not Yet Recruiting
11
Research Site
Macon, Georgia, United States, 31201
Not Yet Recruiting
12
Research Site
Fort Wayne, Indiana, United States, 46804
Not Yet Recruiting
13
Research Site
Des Moines, Iowa, United States, 50309
Not Yet Recruiting
14
Research Site
Iowa City, Iowa, United States, 52242
Not Yet Recruiting
15
Research Site
Louisville, Kentucky, United States, 40207
Not Yet Recruiting
16
Research Site
Baltimore, Maryland, United States, 21201
Not Yet Recruiting
17
Research Site
Bethesda, Maryland, United States, 20817
Not Yet Recruiting
18
Research Site
Boston, Massachusetts, United States, 02215
Not Yet Recruiting
19
Research Site
Ann Arbor, Michigan, United States, 48109
Not Yet Recruiting
20
Research Site
Detroit, Michigan, United States, 48201
Not Yet Recruiting
21
Research Site
Ypsilanti, Michigan, United States, 48197
Not Yet Recruiting
22
Research Site
Springfield, Missouri, United States, 65807
Not Yet Recruiting
23
Research Site
New Brunswick, New Jersey, United States, 08901
Not Yet Recruiting
24
Research Site
New Hyde Park, New York, United States, 11042
Not Yet Recruiting
25
Research Site
New York, New York, United States, 10016
Not Yet Recruiting
26
Research Site
New York, New York, United States, 10032
Not Yet Recruiting
27
Research Site
New York, New York, United States, 10065
Not Yet Recruiting
28
Research Site
Columbus, Ohio, United States, 43210
Not Yet Recruiting
29
Research Site
Pittsburgh, Pennsylvania, United States, 15232
Not Yet Recruiting
30
Research Site
Nashville, Tennessee, United States, 37203
Not Yet Recruiting
31
Research Site
Tacoma, Washington, United States, 98405
Not Yet Recruiting
32
Research Site
Madison, Wisconsin, United States, 53792
Not Yet Recruiting
33
Research Site
Darlinghurst, Australia, 2010
Not Yet Recruiting
34
Research Site
Garran, Australia, 2605
Actively Recruiting
35
Research Site
Heidelberg, Australia, 3084
Actively Recruiting
36
Research Site
Macquarie University, Australia, 2109
Actively Recruiting
37
Research Site
Nedlands, Australia, 6009
Actively Recruiting
38
Research Site
Brussels, Belgium, 1070
Not Yet Recruiting
39
Research Site
Brussels, Belgium, 1090
Not Yet Recruiting
40
Research Site
Ghent, Belgium, 9000
Not Yet Recruiting
41
Research Site
Mechelen, Belgium, 2800
Not Yet Recruiting
42
Research Site
Porto Alegre, Brazil, 90035-003
Actively Recruiting
43
Research Site
São Paulo, Brazil, 04501-000
Actively Recruiting
44
Research Site
São Paulo, Brazil, 05652-900
Actively Recruiting
45
Research Site
Winnipeg, Manitoba, Canada, R3E 0V9
Not Yet Recruiting
46
Research Site
Halifax, Nova Scotia, Canada, B3H 2Y9
Actively Recruiting
47
Research Site
Barrie, Ontario, Canada, L4M 6M2
Withdrawn
48
Research Site
Hamilton, Ontario, Canada, L8V 5C2
Actively Recruiting
49
Research Site
Oshawa, Ontario, Canada, L1G 2B9
Actively Recruiting
50
Research Site
Toronto, Ontario, Canada, M5G 1X6
Actively Recruiting
51
Research Site
Chicoutimi, Quebec, Canada, G7H 5H6
Actively Recruiting
52
Research Site
Montreal, Quebec, Canada, H4J 1C5
Actively Recruiting
53
Research Site
Québec, Quebec, Canada, G1J 1Z4
Actively Recruiting
54
Research Site
Saint-Jérôme, Quebec, Canada, J7Z 2V4
Actively Recruiting
55
Research Site
Beijing, China, 100044
Not Yet Recruiting
56
Research Site
Beijing, China, 100142
Actively Recruiting
57
Research Site
Beijing, China, 100730
Not Yet Recruiting
58
Research Site
Changchun, China, 130021
Not Yet Recruiting
59
Research Site
Changsha, China, 410013
Not Yet Recruiting
60
Research Site
Chengdu, China, 610078
Not Yet Recruiting
61
Research Site
Chongqing, China, 400030
Not Yet Recruiting
62
Research Site
Fuzhou, China, 350001
Not Yet Recruiting
63
Research Site
Guangzhou, China, 510000
Not Yet Recruiting
64
Research Site
Guangzhou, China, 510060
Not Yet Recruiting
65
Research Site
Guangzhou, China, 510100
Not Yet Recruiting
66
Research Site
Hangzhou, China, 310003
Not Yet Recruiting
67
Research Site
Hangzhou, China, 310022
Not Yet Recruiting
68
Research Site
Harbin, China, 150081
Not Yet Recruiting
69
Research Site
Hefei, China, 230031
Not Yet Recruiting
70
Research Site
Lanzhou, China, 730000
Not Yet Recruiting
71
Research Site
Nanchang, China, 330006
Not Yet Recruiting
72
Research Site
Nanchang, China, 330029
Not Yet Recruiting
73
Research Site
Nanjing, China, 210029
Not Yet Recruiting
74
Research Site
Nanning, China, 530021
Not Yet Recruiting
75
Research Site
Shandong, China, 250117
Not Yet Recruiting
76
Research Site
Shanghai, China, 200065
Not Yet Recruiting
77
Research Site
Shanghai, China, 20032
Not Yet Recruiting
78
Research Site
Shenyang, China, 110001
Not Yet Recruiting
79
Research Site
Shenyang, China, 110004
Not Yet Recruiting
80
Research Site
Shijiazhuang, China, 054001
Not Yet Recruiting
81
Research Site
Suzhou, China, 215006
Not Yet Recruiting
82
Research Site
Tianjin, China, 300020
Actively Recruiting
83
Research Site
Wenzhou, China, 325000
Not Yet Recruiting
84
Research Site
Wuhan, China, 430079
Not Yet Recruiting
85
Research Site
Xi'an, China, 710061
Not Yet Recruiting
86
Research Site
Xiamen, China, 361003
Not Yet Recruiting
87
Research Site
Zhengzhou, China, 450000
Not Yet Recruiting
88
Research Site
Zhengzhou, China, 450008
Not Yet Recruiting
89
Research Site
Helsinki, Finland, 00029
Withdrawn
90
Research Site
Kuopio, Finland, 70029
Withdrawn
91
Research Site
Tampere, Finland, 33520
Withdrawn
92
Research Site
Hong Kong, Hong Kong, 999077
Actively Recruiting
93
Research Site
Shatin, Hong Kong, 00000
Actively Recruiting
94
Research Site
Budapest, Hungary, 1122
Withdrawn
95
Research Site
Delhi, India, 110029
Not Yet Recruiting
96
Research Site
Delhi, India, 110085
Not Yet Recruiting
97
Research Site
Gurugram, India, 122002
Not Yet Recruiting
98
Research Site
Kolkata, India, 700160
Not Yet Recruiting
99
Research Site
Nashik, India, 422002
Not Yet Recruiting
100
Research Site
Surat, India, 396007
Not Yet Recruiting
101
Research Site
Thiruvananthapuram, India, 695011
Not Yet Recruiting
102
Research Site
Bunkyō City, Japan, 113-8677
Actively Recruiting
103
Research Site
Chiba, Japan, 260-8717
Actively Recruiting
104
Research Site
Chuo-shi, Japan, 409-3898
Actively Recruiting
105
Research Site
Fukuoka, Japan, 812-8582
Actively Recruiting
106
Research Site
Hirakata-shi, Japan, 573-1191
Actively Recruiting
107
Research Site
Kobe, Japan, 650-0047
Actively Recruiting
108
Research Site
Kōtoku, Japan, 135-8550
Actively Recruiting
109
Research Site
Kumamoto, Japan, 860-8556
Actively Recruiting
110
Research Site
Kurashiki-shi, Japan, 710-8602
Actively Recruiting
111
Research Site
Kyoto, Japan, 602-8566
Actively Recruiting
112
Research Site
Minatoku, Japan, 105-8470
Actively Recruiting
113
Research Site
Okayama, Japan, 700-8558
Actively Recruiting
114
Research Site
Osaka, Japan, 541-8567
Actively Recruiting
115
Research Site
Sapporo, Japan, 003-0006
Actively Recruiting
116
Research Site
Sapporo, Japan, 060-8638
Actively Recruiting
117
Research Site
Sunto-gun, Japan, 411-8777
Actively Recruiting
118
Research Site
Toyoake-shi, Japan, 470-1192
Actively Recruiting
119
Research Site
Yamagata, Japan, 990-9585
Actively Recruiting
120
Research Site
Yokohama, Japan, 241-8515
Actively Recruiting
121
Research Site
Gliwice, Poland, 44-102
Withdrawn
122
Research Site
Busan, South Korea, 49201
Actively Recruiting
123
Research Site
Busan, South Korea, 49241
Actively Recruiting
124
Research Site
Goyang-si, South Korea, 10408
Actively Recruiting
125
Research Site
Jeonnam, South Korea, 519-763
Actively Recruiting
126
Research Site
Seoul, South Korea, 03080
Actively Recruiting
127
Research Site
Seoul, South Korea, 03722
Actively Recruiting
128
Research Site
Seoul, South Korea, 05505
Actively Recruiting
129
Research Site
Seoul, South Korea, 06351
Actively Recruiting
130
Research Site
Seoul, South Korea, 06591
Actively Recruiting
131
Research Site
Barcelona, Spain, 08035
Not Yet Recruiting
132
Research Site
Barcelona, Spain, 8036
Not Yet Recruiting
133
Research Site
El Palmar, Spain, 30120
Not Yet Recruiting
134
Research Site
Girona, Spain, 17007
Not Yet Recruiting
135
Research Site
Las Palmas de Gran Canaria, Spain, 35020
Not Yet Recruiting
136
Research Site
Madrid, Spain, 28040
Not Yet Recruiting
137
Research Site
Madrid, Spain, 28041
Not Yet Recruiting
138
Research Site
Oviedo, Spain, 33011
Not Yet Recruiting
139
Research Site
Pamplona, Spain, 31008
Not Yet Recruiting
140
Research Site
Santander, Spain, 39008
Not Yet Recruiting
141
Research Site
Falun, Sweden, 79182
Withdrawn
142
Research Site
Uppsala, Sweden, 75185
Withdrawn
143
Research Site
Changhua, Taiwan, 50006
Actively Recruiting
144
Research Site
Kaohsiung City, Taiwan, 80756
Actively Recruiting
145
Research Site
Kaohsiung City, Taiwan, 833
Actively Recruiting
146
Research Site
Lukang Township, Taiwan, 505029
Actively Recruiting
147
Research Site
Tainan, Taiwan, 704
Actively Recruiting
148
Research Site
Taipei, Taiwan, 106
Actively Recruiting
149
Research Site
Bangkok, Thailand, 10330
Actively Recruiting
150
Research Site
Bangkok, Thailand, 10700
Actively Recruiting
151
Research Site
Chiang Mai, Thailand, 50200
Actively Recruiting
152
Research Site
Khon Kaen, Thailand, 40002
Actively Recruiting
153
Research Site
London, United Kingdom, EC1M6BQ
Actively Recruiting
154
Research Site
London, United Kingdom, SE5 9RS
Actively Recruiting
155
Research Site
Newcastle upon Tyne, United Kingdom, NE7 7DN
Actively Recruiting
156
Research Site
Norwich, United Kingdom, NR4 7UY
Actively Recruiting
157
Research Site
Nottingham, United Kingdom, NG5 1PB
Actively Recruiting
158
Research Site
Plymouth, United Kingdom, PL6 8DH
Actively Recruiting
159
Research Site
Southampton, United Kingdom, SO16 6YD
Not Yet Recruiting
Research Team
A
AstraZeneca Clinical Study Information Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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