Actively Recruiting
A Study of Targeted Radiation Therapy in People With Non-Small Cell Lung Cancer (NSCLC)
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-05-07
68
Participants Needed
9
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to see whether adding liver stereotactic ablative radiotherapy/L-SABR to standard drug therapy is better than standard drug therapy alone for people with metastatic non-small cell lung cancer/NSCLC.
CONDITIONS
Official Title
A Study of Targeted Radiation Therapy in People With Non-Small Cell Lung Cancer (NSCLC)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be greater than 18 years of age on day of signing informed consent.
- Have a histologically confirmed diagnosis of stage IV NSCLC without known mutations in EGFR, BRAF, ALK, or ROS-1.
- Patients with recurrent metastatic NSCLC after prior durvalumab for stage III NSCLC are eligible if this is their first metastatic immunotherapy.
- Have newly diagnosed metastatic NSCLC with one or more liver metastases.
- Plan to start standard anti-PD-(L)1 based immunotherapy with or without platinum-based chemotherapy for at least 3 cycles.
- Regimens combining anti-CTLA-4 with anti-PD-1 or anti-PD-L1 immunotherapy are allowed.
- Have an ECOG performance status of 0-2.
- Liver function tests must show total bilirubin ≤ 1.5 times the upper limit of normal and AST/ALT ≤ 5 times the upper limit of normal.
- Eligible for L-SABR to all liver metastases as determined by the radiation oncologist.
- Patients with HIV under effective anti-retroviral therapy with CD4 count >200 cells/microliter within 28 days prior to registration.
You will not qualify if you...
- Prior external beam radiation therapy to the liver.
- Known active Hepatitis B or Hepatitis C infection.
- Immunosuppression including use of chronic steroids, cyclosporin, methotrexate, or active autoimmune disease.
- Pregnant or breastfeeding women.
- Men or women not using effective contraception.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 9 locations
1
BAPTIST ALLIANCE - MCI (Data Collection Only)
Miami, Florida, United States, 33143
Actively Recruiting
2
Memorial Sloan Kettering at Basking Ridge (All Protocol Activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
3
Memorial Sloan Kettering Monmouth (All Protocol Activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
4
Memorial Sloan Kettering Bergen (All protocol activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
5
Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities)
Commack, New York, United States, 11725
Actively Recruiting
6
Memorial Sloan Kettering Westchester (All Protocol Activities)
Harrison, New York, United States, 10604
Actively Recruiting
7
Memorial Sloan Kettering Cancer Center (All Protocol Activities)
New York, New York, United States, 10065
Actively Recruiting
8
Memorial Sloan Kettering Nassau (All protocol activities)
Rockville Centre, New York, United States, 11553
Actively Recruiting
9
Lehigh Valley Health Network (Data Collection Only)
Allentown, Pennsylvania, United States, 18103
Actively Recruiting
Research Team
P
Paul Romesser, MD
CONTACT
D
Daniel Gomez, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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