Actively Recruiting
Study of Targeted Therapies for the Treatment of Adult Participants With Active Psoriatic Arthritis
Led by AbbVie · Updated on 2025-12-18
120
Participants Needed
37
Research Sites
142 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Psoriatic arthritis (PsA) is a type of arthritis that happens when the body's immune system attacks healthy cells and tissues causing joint pain, stiffness, and swelling. Symptoms can get worse and go away for periods of time. This study will evaluate the efficacy and safety of targeted therapies through a series of substudies, for the treatment of active psoriatic arthritis and to assess the changes in disease symptoms. The therapies being assessed in this sub-study are risankizumab and lutikizumab. Participants will be randomized in a 1:1:1 ratio to one of the three treatment arms: lutikizumab monotherapy, risankizumab monotherapy or a combination therapy of lutikizumab and risankizumab. Around 120 participants will be enrolled in the study at approximately 40 sites worldwide. There may be higher treatment burden for participants in this trial compared to their standard of care (due to study procedures). Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
CONDITIONS
Official Title
Study of Targeted Therapies for the Treatment of Adult Participants With Active Psoriatic Arthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Willing and able to follow study procedures
- Clinical diagnosis of psoriatic arthritis with symptoms for at least 6 months
- Meets Classification Criteria for Psoriatic Arthritis (CASPAR) at screening
- Active disease with at least 3 tender and 3 swollen joints at screening and baseline
- Active plaque psoriasis or history of plaque psoriasis
- Intolerance or inadequate response to 1 to 2 approved targeted therapies for psoriatic arthritis
You will not qualify if you...
- Major surgery within 12 weeks before randomization or planned during the study
- Infection with HIV, active hepatitis B or C, or active tuberculosis
- Active skin diseases other than psoriasis that affect psoriasis assessment
- History of fibromyalgia, arthritis before age 17, or other inflammatory joint diseases like rheumatoid arthritis or lupus
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 37 locations
1
Newport Huntington Medical Group /ID# 272764
Huntington Beach, California, United States, 92648-5994
Actively Recruiting
2
Highlands Advanced Rheumatology And Arthritis Center - Avon Park /ID# 273085
Avon Park, Florida, United States, 33825
Actively Recruiting
3
Clinical Research Of West Florida - Phase I Unit /ID# 273198
Clearwater, Florida, United States, 33765
Actively Recruiting
4
HMD Research LLC /ID# 273086
Orlando, Florida, United States, 32819
Actively Recruiting
5
West Broward Rheumatology Associates /ID# 272892
Tamarac, Florida, United States, 33321
Actively Recruiting
6
Clinical Research Of West Florida - Tampa - North Howard Avenue /ID# 273199
Tampa, Florida, United States, 33606
Actively Recruiting
7
Clinic Of Dr. Robert Hozman/Clinical Investigation Specialists, Inc /ID# 272879
Skokie, Illinois, United States, 60076
Actively Recruiting
8
Willow Rheumatology and Wellness, PLLC /ID# 277354
Willowbrook, Illinois, United States, 60527
Actively Recruiting
9
Klein And Associates /ID# 272829
Hagerstown, Maryland, United States, 21740
Completed
10
Paramount Medical Research and Consulting /ID# 272757
Middleburg Heights, Ohio, United States, 44130
Actively Recruiting
11
Altoona Center For Clinical Research /ID# 272593
Duncansville, Pennsylvania, United States, 16635
Actively Recruiting
12
Private Practice - Dr. Ramesh C. Gupta I /ID# 272897
Memphis, Tennessee, United States, 38119
Actively Recruiting
13
Tekton Research - West Gate /ID# 272765
Austin, Texas, United States, 78745
Actively Recruiting
14
Accurate Clinical Research - Houston /ID# 272754
Houston, Texas, United States, 77089-6142
Actively Recruiting
15
Tekton Research, LLC /ID# 272901
San Antonio, Texas, United States, 78251
Actively Recruiting
16
Dynamed Clinical Research - Tomball /ID# 272760
Tomball, Texas, United States, 77375
Actively Recruiting
17
Centre de Recherche Musculo-Squelettique /ID# 274397
Trois-Rivières, Quebec, Canada, G9A 3X2
Actively Recruiting
18
Dr. Latha Naik Medical Professional Corporation /ID# 272803
Saskatoon, Saskatchewan, Canada, S7H 0P4
Actively Recruiting
19
Revmatologie /ID# 272367
Brno, Brno-mesto, Czechia, 638 00
Actively Recruiting
20
L.K.N. Arthrocentrum /ID# 272366
Hlučín, Moravian-Silesian Region, Czechia, 748 01
Actively Recruiting
21
Medical Plus s.r.o. /ID# 272363
Uherské Hradiště, Czechia, 686 01
Actively Recruiting
22
PV Medical Services s.r.o. /ID# 272368
Zlín, Czechia, 760 01
Actively Recruiting
23
Centre Hospitalier Universitaire de Nice - Hopital Pasteur /ID# 272771
Nice, Alpes-Maritimes, France, 06001
Actively Recruiting
24
Infirmerie Protestante De Lyon /ID# 273731
Caluire-et-Cuire, Auvergne-Rhône-Alpes, France, 69300
Actively Recruiting
25
Centre Hospitalier Régional Universitaire De Tours - Hôpital Trousseau /ID# 272762
Chambray-lès-Tours, Indre-et-Loire, France, 37170
Actively Recruiting
26
CHU Bordeaux - Hopital Pellegrin /ID# 273390
Bordeaux, New Aquitaine, France, 33076
Actively Recruiting
27
Centre Hospitalier Régional d'Orléans - Hôpital de la Source /ID# 272877
Orléans, France, 45067
Actively Recruiting
28
Borsod-Abauj-Zemplen Varmegyei Kozponti Korhaz es Egyetemi Oktatokorhaz /ID# 272572
Miskolc, Borsod-Abauj Zemplen county, Hungary, 3529
Actively Recruiting
29
Complex Rendelo Med Zrt. /ID# 272570
Székesfehérvár, Fejér, Hungary, 8000
Actively Recruiting
30
Vital-Medicina Kft. /ID# 272855
Veszprém, Fejér, Hungary, 8200
Actively Recruiting
31
Semmelweis Egyetem Reumatológiai és Immunológiai Klinika /ID# 273195
Budapest, Hungary, 1023
Actively Recruiting
32
Revita Reumatologiai Rendelo (Revita Kft.) /ID# 272857
Budapest, Hungary, 1027
Actively Recruiting
33
Mics Centrum Medyczne Bydgoszcz /ID# 273297
Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland, 85-068
Actively Recruiting
34
MCBK S.C. Iwona Czajkowska Anna Podrazka-Szczepaniak /ID# 273305
Pruszków, Masovian Voivodeship, Poland, 05-800
Actively Recruiting
35
Centrum Medyczne Reuma Park /ID# 273301
Warsaw, Masovian Voivodeship, Poland, 02-665
Actively Recruiting
36
Osteo Medic s.c. Artur Racewicz Jerzy Supronik /ID# 273304
Bialystok, Podlaskie Voivodeship, Poland, 15-351
Actively Recruiting
37
Centrum Kliniczno-Badawcze J.Brzezicki, B. Gornikiewicz-Brzezicka Lekarze Spolka /ID# 273306
Elblag, Warmian-Masurian Voivodeship, Poland, 82-300
Actively Recruiting
Research Team
A
ABBVIE CALL CENTER
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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